Navigation Links
Scientists learn more about rare skin cancer that killed Bob Marley
Date:8/20/2014

Cancer Research UK scientists have discovered that acral melanomas the rare type of skin cancer that caused reggae musician Bob Marley's death are genetically distinct from other more common types of skin cancer, according to a study (link is external) published in the journal Pigment Cell & Melanoma Research.

Acral melanoma most often affects the palms of the hands, soles of the feet, nail-beds and other hairless parts of the skin. Unlike other more common types of melanoma, it's not caused by UV damage from the sun.

The team, from the Cancer Research UK Manchester Institute (link is external) at The University of Manchester (link is external), sequenced the tumours of five patients with acral melanoma and combined this with data from three other patients. They then compared the pattern of genetic faults found in these eight tumours with that of more common types of skin cancer.

This revealed that the type of DNA damage found in acral melanoma is very different from other types of skin cancer. For example in acral melanomas, it was much more common to find large chunks of the DNA that had broken off and reattached elsewhere, as opposed to the smaller DNA changes typically found in more common types of skin cancer.

Study leader Professor Richard Marais, director of the Cancer Research UK Manchester Institute, at The University of Manchester, said: "Too much UV radiation from the sun or sunbeds can lead to a build-up of DNA damage that increases skin cancer risk. But acral skin cancer is different because the gene faults that drive it aren't caused by UV damage. Pinpointing these faults is a major step towards understanding what causes this unique form of cancer, and how it can best be treated."

Nell Barrie, senior science information manager at Cancer Research UK, said: "We hope that understanding the faults that drive acral melanoma will unlock better ways of treating this rare yet aggressive type of skin cancer. Our scientists are striving to improve survival for all cancer patients, including those with rarer forms of the disease.

"And this is why skin cancer will be a key research focus for the Manchester Cancer Research Centre."


'/>"/>

Contact: Flora Malein
flora.malein@cancer.org.uk
44-020-346-96189
Cancer Research UK
Source:Eurekalert

Related biology news :

1. Scientists study talking turtles in Brazilian Amazon
2. Scientists discover the miracle of how geckos move, cling to ceilings
3. Scientists discover how jumping genes help black truffles adapt to their environment
4. NOAA, EPA-supported scientists find average but large Gulf dead zone
5. Scientists name new species of cetacean: The Australian humpback dolphin
6. Scripps Research Institute scientists find new calorie-burning switch in brown fat
7. Scientists warn time to stop drilling in the dark
8. Scientists find growing consensus: Political attitudes derive from body and mind
9. Scientists shine bright new light on how living things capture energy from the sun
10. Scientists discover biochemical mechanisms contributing to fibromuscular dysplasia
11. Conservation scientists asking wrong questions on climate change impacts on wildlife
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/26/2019)... ... 25, 2019 , ... Lemnis Technologies, the technology company behind ... a new generation eye tracker with hassle-free calibration. The headsets will be demonstrated ... - August 1). SIGGRAPH attendees will be able to try Verifocal™ headsets in ...
(Date:7/23/2019)... ... July 22, 2019 , ... Personalized Stem Cells, Inc (“PSC”), a human ... for use of a person’s own adipose-derived stem cells to treat their osteoarthritis. The ... of osteoarthritis in the knee. , This is the first of several ...
(Date:7/19/2019)... POWAY, Calif. (PRWEB) , ... July 18, 2019 , ... ... with clinical, regulatory and manufacturing experience. As a result of a two-year ... to commercialize the Calidi oncolytic virus platform in veterinary medicine. VetStem should be ...
Breaking Biology News(10 mins):
(Date:7/19/2019)... , ... July 18, 2019 , ... ... announced their investment to enlarge their current piezo motion facilities in Lederhose, Germany, ... 3 floors for multilayer piezo ceramic assembly production in addition to general office ...
(Date:7/17/2019)... ... July 16, 2019 , ... ... a recent report from Kalorama Information. Abbott, Roche and Siemens Healthineers and Response ... Information’s latest report, Worldwide Market for Point-of-Care (POC) Diagnostics . , Quidel ...
(Date:7/2/2019)... ... 02, 2019 , ... Leading Regenerative Veterinary Medicine company, VetStem Biopharma , ... The film focuses on regenerative veterinary medicine as a means of improving the ... included in the Brentwood and Pacific Palisades International Film Festival in Los Angeles, ...
(Date:6/12/2019)... ... June 12, 2019 , ... ... testing instruments for the Pharmaceutical, Biotechnology, Medical Device and Food Packaging Industries, is ... signed. The agreement will grant exclusive rights for Zillion to represent LDA in ...
Breaking Biology Technology: