Navigation Links
Scientists learn how pathogens hack our immune systems to go undetected
Date:2/27/2014

A new report appearing in the March 2014 issue of The FASEB Journal helps shed light on what drives the evolution of pathogens, as well as how our bodies adapt to ward them off. Specifically, the report shows that our bodies naturally employ a mechanism, called "CD33rSiglecs," that not only dampens unwanted immune responses against one's own cells, but also evolves rapidly to recognize foreign invaders. What's more, the report explains how pathogens exploit this immunological "vulnerability" of "self-recognition" to evade our bodies' defenses. This leads to a seemingly endless "arms race" between constantly evolving pathogens and immune systems. Understanding this phenomenon may become crucial for developing novel drugs against various pathogens that try to take advantage of this system.

"Our data explain why the CD33rSiglec-encoding cluster of genes is undergoing rapid evolution via multiple mechanisms, driven by the need to maintain self-recognition by innate immune cells, even while escaping two distinct mechanisms of subversion by pathogens," said Ajit Varki, M.D., a researcher involved in the work from the Departments of Medicine and Cellular and Molecular Medicine at the University of California in San Diego, CA.

Please note: Non-human samples used for these studies were collected under ethical standards and approval processes similar to those that apply to humans, and that no animals were harmed in these studies.

To make this discovery, Varki and colleagues compared three major CD33rSiglecs from humans, chimpanzees and baboons. While chimpanzees and baboons express two types, Neu5Ac and Neu5Gc, humans express only one, Neu5Ac. They then compared specific binding properties and expression patterns of these CD33rSiglecs and found that while related CD33rSiglecs from humans, chimpanzees and baboons recognize pathogenic bacteria, they do so differently. Additionally, different types of CD33rSiglecs within the same species also showed similar variances.

"Just like malicious computer software programs, these pathogens 'hack' our immune systems with the goal of going undetected," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "Now that we understand how these pathogens are hacking our immune systems, we can understand how evolution has permitted us to distinguish the 'self' our immune system ignores from the 'non-self' the system evolved to combat."


'/>"/>
Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Related biology news :

1. NPL scientists blend synthetic air to measure climate change
2. Southern insect scientists meeting in Greenville, S.C.
3. Scientists transform skin cells into functioning liver cells
4. Scientists unlock a microbial Pompeii
5. Scientists identify long distance scanner for DNA damage
6. A*STAR scientists discover proteins role in human memory and learning functions
7. Kids and insect scientists to meet in San Antonio
8. Wistar scientists develop gene test to accurately classify brain tumors
9. Ticks may cause double trouble, Stanford scientists find
10. Scientists call for new stewardship of the deep ocean: Earths last frontier
11. Thinking it through: Scientists seek to unlock mysteries of the brain
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/13/2017)... According to a new market research report "Consumer IAM Market by Solution ... Authentication Type, Deployment Mode, Vertical, and Region - Global Forecast to 2022", ... 14.30 Billion in 2017 to USD 31.75 Billion by 2022, at a ... ... MarketsandMarkets Logo ...
(Date:4/11/2017)... 11, 2017 NXT-ID, Inc. (NASDAQ:   ... announces the appointment of independent Directors Mr. Robin D. ... Board of Directors, furthering the company,s corporate governance and expertise. ... Gino Pereira , ... forward to their guidance and benefiting from their considerable expertise ...
(Date:4/5/2017)... KEY FINDINGS The global market ... CAGR of 25.76% during the forecast period of 2017-2025. ... for the growth of the stem cell market. ... MARKET INSIGHTS The global stem cell market is segmented ... The stem cell market of the product is segmented ...
Breaking Biology News(10 mins):
(Date:4/19/2017)... Linda, Ca (PRWEB) , ... April 18, 2017 , ... ... new technological advances. This webinar, which is part of the Protein and Cell ... Flow Cytometer and outline where this technology fits in current and future applications. ...
(Date:4/19/2017)... ... April 18, 2017 , ... Optofluidics today announced ... comes after the company changed focus to making analytical tools for biopharmaceutical quality ... new technology,” says CEO Robert Hart. Founders Bernardo Cordovez, Robert Hart and David ...
(Date:4/19/2017)... MA (PRWEB) , ... April 19, 2017 , ... ... a $1.5M Series A-1 financing round. This event adds to several other early ... of its’ Executive and Scientific Teams. , ThermaGenix will use proceeds ...
(Date:4/19/2017)... ... April 19, 2017 , ... As ... educational webinars accessible to novices as well as experienced users, attendees will gain ... performed coagulation screening tests. , Hemostasis testing quality is determined by preanalytical ...
Breaking Biology Technology: