Navigation Links
Scientists launch first comprehensive database of human oral microbiome
Date:3/26/2008

Scientists know more today than ever before about the microbes that inhabit our mouths. They know so much, in fact, that gathering all of the relevant bits of information into one place when designing experiments can be a job in itself. Now, grantees of the National Institute of Dental and Craniofacial Research (NIDCR), part of the National Institutes of Health, and their international colleagues intend to solve this problem with the launch of the first comprehensive database of the oral microbiome, or the approximately 600 distinct microorganisms currently known to live in the mouth.

The free online compendium is called the Human Oral Microbiome Database (HOMD). The database goes live today as the digital equivalent of an Oxford dictionary of oral microorganisms, providing detailed biological entries for each species and an extensive catalogue of the thousands of genes that these microbes express. The site is located at http://www.homd.org and is overseen by scientists at The Forsyth Institute in Boston and Kings College London in England.

The HOMD fills a critical research need, said NIDCR director Lawrence Tabak, D.D.S., Ph.D. The oral microbiome is extremely rich in data, and HOMD becomes the essential search engine for scientists to view and retrieve this information, generate novel hypotheses, make computational discoveries, and ultimately develop more biologically sound therapies to control oral diseases.

According to Floyd Dewhirst, D.D.S., Ph.D., a leader of the project and a scientist at The Forsyth Institute, HOMD also introduces the first comprehensive nomenclature system to bring order to the naming of uncultured or previously unnamed oral microbes. The standardized numbering system helps to eliminate the Babel of confusing names and uninformative database designations that have frustrated scientists and sometimes hindered their research.

The database also categorizes each microbe by its 16S rRNA sequence, a distinctive fingerprint of genetic information that scientists have used for the past two decades to identify microorganisms. This sequence information allows the microbes to be placed in a family tree that shows how they are related to one another. For those organisms whose DNA has been sequenced, HOMD provides online tools to view and analyze all of their genes and proteins. Each category of information in the database is interlinked, readily searchable, appropriately annotated, and will be frequently updated to remain current.

Dewhirst noted that although HOMD has officially opened to scientists, the database remains an ongoing project. Weve already assembled a great deal of useful information for the research community, but we will continue to expand and refine the database for the next several years, said Dewhirst. I can see the Human Oral Microbiome Database serving as a valuable model for other microbiome databases now and in the years to come.

Informally called biologys next revolution, microbiome studies have opened a needed window into the complex microbial communities that occupy most parts of the human body. These studies will define how microbes contribute to sustaining health and, when their community dynamics are perturbed, play a role in common chronic disease, such as tooth decay and periodontal disease in the mouth. In December 2007, NIH launched the Human Microbiome Project that initially will sequence all of the genes, or genomes, of 600 representative microorganisms sampled from microbial communities in the mouth, skin, digestive tract, nose, and female urogenital tract. Additional studies are either under way or under development.

Among those already well under way is a NIDCR-supported project to compile a full catalogue of the complete genomes of all oral microbes. It has generated a tremendous amount of data and, coupled with the decades of more traditional studies of oral bacteria, the need for a comprehensive, user-friendly database has become a priority.

The oral microbiome is currently better understood than those of other sites in the body, such as the intestine, said Dr. Bruce Paster, Ph.D., also at The Forsyth Institute and another project scientist. Since oral microorganisms appear in infections throughout the human body, the HOMD database certainly will be useful to physicians. Likewise, microbiologists in industry will find HOMD helpful because oral microbes sometimes contaminate food or the drug manufacturing process.


'/>"/>

Contact: Bob Kuska
kuskar@nidcr.nih.gov
301-594-7560
NIH/National Institute of Dental and Craniofacial Research
Source:Eurekalert

Related biology news :

1. NYU scientists set stage for understanding how color vision is processed
2. Scientists launch human oral microbiome database
3. Yale scientists show that a microRNA can reduce lung cancer growth
4. Texas A&M scientists say early Americans arrived earlier
5. Scientists find color vision system independent of motion detection
6. Crop scientists discover gene that controls fruit shape
7. Scientists discover how TB develops invincibility against only available treatment
8. Scientists show that streams are critical to preservation of oceanic coastal zones
9. Scientists to discover why flamingos are in the pink of health -- in the poo!
10. Scientists believe photograph depicts wolverine in California
11. Scientists successfully treat new mouse model of inflammatory bowel disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/28/2017)... 28, 2017   Acuant , a leading provider ... significant enhancements to new and core technologies building upon ... include mobile and desktop Acuant FRM TM facial ... a real time manual review of identity documents by ... the fastest and most accurate capture software to streamline ...
(Date:2/26/2017)... DALLAS , Feb. 25, 2017  Securus ... justice technology solutions for public safety, investigation, corrections ... of Recidivism and Reentry. "Too often, ... State prisons and county jails are trying to ... of inmates and friends and family members. While significant ...
(Date:2/21/2017)... -- Der weltweite Biobanking-Sektor wird bis zum ... mit mehr als 50 Vertretern aus verschiedenen Branchen wurde aber ... diese Prognose zu realisieren. ... Zu den Schwierigkeiten für ... für die Biobank, die Implementierung Zeit sparender Technologien, ein ...
Breaking Biology News(10 mins):
(Date:3/27/2017)... -- Roka Bioscience, Inc. (NASDAQ: ROKA), a molecular diagnostics company ... foodborne pathogens,  today announced that Mary Duseau , CEO ... on March 29 at 9:50am ET. The conference will be ... About Roka Bioscience ... Roka Bioscience is a molecular diagnostics company ...
(Date:3/27/2017)... ... 27, 2017 , ... IsoPlexis Corporation (IsoPlexis), a venture capital-funded ... more through a single-cell precision engineering platform, today announced it has received an ... the laboratory of Dr. James Heath at the California Institute of Technology, a ...
(Date:3/27/2017)... , March 27, 2017 Cousins Properties (NYSE: ... world,s leading biotechnology companies, has signed a 10-year, approximately 125,000 ... A office asset located in the Westshore submarket of ... thrilled that Amgen has chosen Corporate Center for their new ... Gellerstedt , president and chief executive officer of Cousins Properties. ...
(Date:3/27/2017)... Ca (PRWEB) , ... March 27, 2017 , ... ... colorectal cancer (mCRC) generally produce small, heterogeneous samples with limited tumor content in ... challenges remain to be resolved, such as the need for reliable detection of ...
Breaking Biology Technology: