Navigation Links
Scientists identify what makes us feel 'bad' when we're sick, how to treat it
Date:8/3/2011

PORTLAND, Ore. A signaling system in the brain previously shown to regulate sleep is also responsible for inducing lethargy during illness, according to research conducted at Oregon Health & Science University Doernbecher Children's Hospital.

This research is particularly meaningful because it implies that a new class of drugs developed to treat sleep disorders can reverse the inactivity and exhaustion brought on by acute illness. Although the sleep drugs were initially designed to treat narcolepsy, they have the potential to restore energy and motivation in patients with acute and chronic disease, the researchers report. Their findings are published in the The Journal of Neuroscience.

"We all know what it means to feel 'bad' when we're acutely ill. In particular, patients with chronic diseases experience a compromise in motivated behaviors. They don't feel like getting up and doing anything. Yet the brain mechanisms behind this common experience have remained obscure," said Daniel L. Marks, M.D., Ph.D., principal investigator and associate professor of pediatrics in the Pap Family Pediatric Research Institute at OHSU Doernbecher Children's Hospital.

"Our lab has found that the neurotransmitter system thought to be primarily involved in the induction of sleep is actually extremely important in maintaining motivation and movement during acute and chronic illness," Marks explained.

Research has shown that in response to illness, animals divert all their energy to fight infection. Lethargy, fever and loss of appetite are symptoms of the body's highly organized strategy to sacrifice biological and physiological priorities to provide the greatest chance of survival.

Although previous studies have identified the neurotransmitter system in the brain responsible for inducing fever and loss of appetite in response to disease, the mechanism for suppressing physical activity and motivation, and the means to treat it,
'/>"/>

Contact: Tamara Hargens-Bradley
hargenst@ohsu.edu
503-494-8231
Oregon Health & Science University
Source:Eurekalert

Page: 1 2

Related biology news :

1. CSHL scientists reveal mechanism behind oncogene addiction in acute leukemia
2. Scientists take a giant step for people -- with plants!
3. Scientists report dramatic carbon loss from massive Arctic wildfire
4. Toucans wearing GPS backpacks help Smithsonian scientists study seed dispersal
5. 12 scientists named ASBMB award winners
6. Think healthy, eat healthy: Caltech scientists show link between attention and self-control
7. Scientists design nano-sized drug transporter to fight disease
8. Life scientists use novel technique to produce genetic map for African Americans
9. Fools gold gives scientists priceless insight into Earths evolution
10. A*Star scientists discover how to combat hospital-acquired infections and life-threatening toxins
11. UCLA scientists complete first mapping of molecule found in human embryonic stem cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/31/2014)... for sniffing the highly infectious bacteria C. diff ... been developed by a team at the University of ... has demonstrated that it is possible to identify the ... lead to rapid diagnosis of the condition., What is ... to identify different strains of the disease simply from ...
(Date:8/31/2014)... Nature Climate Change , suggests that if current ... exceed, the global targets for total greenhouse gas (GHG) emissions ... all think carefully about the food we choose and its ... is just one of a number of actions that need ... there is enough food for all. , As populations ...
(Date:8/29/2014)... 2014) Scientists at the Barshop Institute for Longevity ... at the UT Health Science Center at San Antonio, ... of the longest-lived rodent, the naked mole rat. ... of naked mole rats protects and alters the activity ... obsolete proteins. , The factor also protects proteasome function ...
Breaking Biology News(10 mins):Scientists develop 'electronic nose' for rapid detection of C. diff infection 2Changing global diets is vital to reducing climate change 2Changing global diets is vital to reducing climate change 3Changing global diets is vital to reducing climate change 4Factor in naked mole rat's cells enhances protein integrity 2
... rate of pine tree seedlings by changing when and ... "There's been too many (reforestation) failures over the last ... Extension forestry specialist. , "Some landowners have had to ... row because of poor seedling survival." , Second-year data ...
... The University of Texas M. D. Anderson Cancer Center ... so that it permanently hampers breast cancer development. The ... in some human breast tumors, thus reducing the cancer's ... the annual meeting of the American Association for Cancer ...
... Carolina at Chapel Hill is one of five clinical ... of Health to study why good medications are sometimes ... years, the Drug-Induced Liver Injury Network, or DILIN, will ... by prescription and over-the-counter medications, nutritional supplements, alternative medicines ...
Cached Biology News:Shift of weather patterns necessitates rethinking of reforestation methods 2Shift of weather patterns necessitates rethinking of reforestation methods 3Used in a new way, RNA interference permanently silences key breast cancer gene 2UNC launches study of liver injury caused by drugs 2
(Date:8/30/2014)... The Global and China Electrical Insulating ... on the current state of the Electrical Insulating ... report provides a basic overview of the industry, ... market analysis and Chinese domestic market analysis are ... and competitive landscape of the market. A comparison ...
(Date:8/29/2014)... Pittcon is pleased to announce that the ... Horiba Scientific, have organized a session on nanotechnology for ... , Asia’s largest analytical and scientific instruments show, will ... , The four speakers in this U.S. symposium, ... to Single Cells” will present their use of nanotechnology ...
(Date:8/29/2014)... (PRWEB) August 29, 2014 A major ... the biotech start-up dense realm of Boston-Cambridge, is gaining ... able investors. James Sherley, the Director of Boston’s Adult ... the local and national visibility of his company an ... 2013. , In addition to a social media marketing ...
(Date:8/28/2014)... August 28, 2014 “This kit has an ... screen from 0 to 150 ppb,” said Mark Tess, PhD, ... significant benefit to plant owners and USDA-GIPSA inspection agencies that ... commodities. Testing can take place in a matter of minutes ... the plant test the feed and grain before accepting it, ...
Breaking Biology Technology:Electrical Insulating Varnish Market World, China Regional Analysis & 2020 Forecasts Available at DeepResearchReports.com 2Electrical Insulating Varnish Market World, China Regional Analysis & 2020 Forecasts Available at DeepResearchReports.com 3Fifth Annual U.S. Symposium at JASIS Organized by Pittcon’s Program Chairman Hub MacDonald 2The Adult Stem Cell Technology Center, LLC Participates in Multiple Stem Cell and Regenerative Medicine Conferences Before Year End 2The Adult Stem Cell Technology Center, LLC Participates in Multiple Stem Cell and Regenerative Medicine Conferences Before Year End 3The Adult Stem Cell Technology Center, LLC Participates in Multiple Stem Cell and Regenerative Medicine Conferences Before Year End 4
... today announced a commitment of more than a half million ... the ACC Foundation to fund and support a new ACC ... $530,000 contribution will be to offer financial support through research ... ,This awards program is an investment in young researchers and ...
... between Wisconsins biotechnology sector and other well-established biotech regions ... Engineering News featuring Wisconsins biotech sector as Americas ... leaders. , ,The East and West Coasts are often ... to flourish, some believe Wisconsin is catching up. According ...
... as social networking has. In fact, I get more mail when ... all other topics combined. (Something I suppose I should keep in ... ,Last week, I wrote that social networking "eludes a business model ... in actively working the network to your business benefit. Whatever the ...
Cached Biology Technology:Wisconsin's biotech industry recognized by national publication 2Social networks: Readers respond 2Social networks: Readers respond 3Social networks: Readers respond 4
...
... the first all-inclusive collection of key procedures ... System. Methods developed by the leaders in ... protocols. This book will guide you from ... construction and analysis, to production of your ...
...
...
Biology Products: