PORTLAND, Ore. A signaling system in the brain previously shown to regulate sleep is also responsible for inducing lethargy during illness, according to research conducted at Oregon Health & Science University Doernbecher Children's Hospital.
This research is particularly meaningful because it implies that a new class of drugs developed to treat sleep disorders can reverse the inactivity and exhaustion brought on by acute illness. Although the sleep drugs were initially designed to treat narcolepsy, they have the potential to restore energy and motivation in patients with acute and chronic disease, the researchers report. Their findings are published in the The Journal of Neuroscience.
"We all know what it means to feel 'bad' when we're acutely ill. In particular, patients with chronic diseases experience a compromise in motivated behaviors. They don't feel like getting up and doing anything. Yet the brain mechanisms behind this common experience have remained obscure," said Daniel L. Marks, M.D., Ph.D., principal investigator and associate professor of pediatrics in the Pap Family Pediatric Research Institute at OHSU Doernbecher Children's Hospital.
"Our lab has found that the neurotransmitter system thought to be primarily involved in the induction of sleep is actually extremely important in maintaining motivation and movement during acute and chronic illness," Marks explained.
Research has shown that in response to illness, animals divert all their energy to fight infection. Lethargy, fever and loss of appetite are symptoms of the body's highly organized strategy to sacrifice biological and physiological priorities to provide the greatest chance of survival.
Although previous studies have identified the neurotransmitter system in the brain responsible for inducing fever and loss of appetite in response to disease, the mechanism for suppressing physical activity and motivation, and the means to treat it,
|Contact: Tamara Hargens-Bradley|
Oregon Health & Science University