Navigation Links
Scientists identify the genes that cause blindness produced by corneal edema
Date:9/18/2008

This press release is available in French and Spanish.

Scientists of the University of Granada (Spain) and the San Cecilio Teaching Hospital (Granada) have determined for the first time the causes for the blindness produced by corneal oedema and have identified the genes which cause it. The research group of Tissue Engineering of the UGR and the San Cecilio University Hospital, who has recently constructed the first complete artificial cornea, has established in a research work which has just been published in the journal 'Experimental Eye Research' new findings related to blindness caused by corneal oedema originated by the alteration of the cell barrier of corneal endothelium. When the endothelial cell barrier is unharmed, the cornea remains dehydrated and transparent.

An oedema is a swelling caused by the accumulation of liquid in the tissues of the human body, including cornea. The researchers of Granada have proved that the alteration of the mechanisms that regulate the volume of endothelial cells and their content in ions is the cause for which the endothelial barrier stops being effective in the control of corneal transparency.

Ion concentration

The research work has experimentally established the volume and concentration of ions in cells when they make up the endothelial barrier and when they stop forming it. If, due to a traumatism, cataract surgery, ageing, etc., the barrier of endothelial cells breaks, dispersed cells increase their volume and content in ions, potassium and chlorine. The goal of these changes is to repair the endothelial barrier, prevent corneal oedema and, therefore, the loss of transparency and the resulting blindness. The research carried out in the University of Granada has also determined the genes involved in the control of such process.

Such recent findings suggest new treatments for corneal oedema. The scientists explain that maybe in the not too distant future it will be possible to use eye drops which provide the ions involved or even the possibility of modifying the affected genes by means of gene therapy, which could mend or palliate some of these alterations.


'/>"/>

Contact: Antonio Campos Muoz
acampos@ugr.es
34-958-243-514
Universidad de Granada
Source:Eurekalert

Related biology news :

1. UK scientists working to help cut ID theft
2. Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
3. Comet probes reveal evidence of origin of life, scientists claim
4. Scientists link fragile X tremor/ataxia syndrome to binding protein in RNA
5. Male elephants get photo IDs from scientists
6. Scientists retrace evolution with first atomic structure of an ancient protein
7. Muscle mass: Scientists identify novel mode of transcriptional regulation during myogenesis
8. Carnegie Mellon scientists develop nanogels that enable controlled delivery of carbohydrate drugs
9. Clemson scientists shed light on molecules in living cells
10. Scientists tackle mystery mountain illness
11. T. rex quicker than Becks, say scientists
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/9/2016)... , June 9, 2016  Perkotek an innovation leader in attendance control systems is ... log work hours, for employers to make sure the right employees are actually signing ... http://photos.prnewswire.com/prnh/20160609/377486LOGO ... ... ...
(Date:6/7/2016)... -- Syngrafii Inc. and San Antonio Credit Union (SACU) ... Syngrafii,s patented LongPen™ eSignature "Wet" solution into SACU,s ... in greater convenience for SACU members and operational ... document workflow and compliance requirements. Logo ... Highlights: ...
(Date:6/2/2016)... The Department of Transport Management (DOTM) of ... project, for the , Supply and Delivery of ... Infrastructure , to Decatur , ... Management Solutions. Numerous renowned international vendors participated in the tendering ... selected for the most compliant and innovative solution. The contract ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... , June 23, 2016  The Prostate Cancer Foundation (PCF) ... precise treatments and faster cures for prostate cancer. Members of the Class of ... 15 countries. Read More About the Class of 2016 ... ... ...
(Date:6/23/2016)... , June 23, 2016   EpiBiome , ... secured $1 million in debt financing from Silicon Valley ... up automation and to advance its drug development efforts, ... new facility. "SVB has been an incredible ... the services a traditional bank would provide," said Dr. ...
(Date:6/23/2016)... OTTAWA, ON (PRWEB) , ... June 23, 2016 , ... ... former DNA Technical Leader at the Arkansas State Crime Laboratory, has joined STACS DNA ... joining the STACS DNA team,” said Jocelyn Tremblay, President and COO of STACS DNA. ...
(Date:6/23/2016)... 2016 Apellis Pharmaceuticals, Inc. today announced ... of its complement C3 inhibitor, APL-2. The trials ... dose studies designed to assess the safety, tolerability, ... in healthy adult volunteers. Forty subjects ... single dose (ranging from 45 to 1,440mg) or ...
Breaking Biology Technology: