Navigation Links
Scientists identify prostate cancer stem cells among low-PSA cells
Date:5/4/2012

HOUSTON Prostate cancer cells that defy treatment and display heightened tumor-generating capacity can be identified by levels of prostate specific antigen (PSA) expressed in the tumor cells, a research team led by scientists at The University of Texas MD Anderson Cancer Center reports in the May 3 edition of Cell Stem Cell.

"Using a new technique, we were able for the first time to separate low-PSA and high-PSA prostate cancer cells. This led to the discovery of a low-PSA population of cancer stem cells that appears to be an important source of castration-resistant prostate cancer," said study senior author Dean Tang, Ph.D., professor in MD Anderson's Department of Molecular Carcinogenesis.

Hormone therapy is used to block production of testosterone, which fuels prostate cancer growth, via either chemical or physical castration. Tumors eventually resist this approach.

In cell lines and mouse model experiments, the low-PSA cells resisted chemotherapy and thrived under hormone deprivation, the two main prostate cancer drug treatments , the researchers found.

Low-PSA cells were found to be both self-renewing and capable of differentiating into other prostate cancer cell types upon division, a hallmark of stem cells called asymmetric cell division.

"Asymmetric cell division is the gold standard feature of normal stem cells," Tang said. "Using time-lapse fluorescent microscopy, we were able to show asymmetric cell division by filming a low-PSA cell dividing into one high-PSA cell and one low-PSA cell."

Their findings point to the need to develop new therapeutics to target low-PSA prostate cancer cells that can be combined with hormone therapy to wipe out cancer cells and prevent recurrence.

Low-PSA tumors associated with advanced prostate cancer

Previous research by others indicated that low-PSA tumor cells are rare in early stage disease but become more abundant in advanced prosta
'/>"/>

Contact: Scott Merville
smerville@mdanderson.org
713-792-0655
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Scientists core into Californias Clear Lake to explore past climate change
2. Scientists make stunning inner space observations
3. Scientists discover enzyme that could slow part of the aging process in astronauts -- and the elderly
4. Scientists uncover exciting lead into premature aging and heart disease
5. March of Dimes awards $250,000 prize to 2 scientists who pioneered advances in skin disorders
6. Scientists provide first large-scale estimate of reef shark losses in the Pacific Ocean
7. Stanford and MIT scientists win Perl-UNC Neuroscience prize
8. Queens is UK leader for female scientists and engineers
9. Scientists uncover strong support for once-marginalized theory on Parkinsons disease
10. Scientists develop new technique that could improve heart attack prediction
11. Scientists advance field of research with publication of newly validated method for analyzing flavanols in cocoa
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... Long before humans figured out how to create colors, ... bright butterfly wings of many different hues, for example. ... a more environmentally friendly way to make colored plastics. ... and architectures of materials rather than dyes, to ... Letters . , N. Asger Mortensen, Anders Kristensen and ...
(Date:7/30/2014)... Chown has been awarded the Scientific Committee on ... Antarctic Research. , SCAR, an inter-disciplinary international science ... scientific research in the Antarctic region, and on ... Earth system. The organisation also provides scientific advice ... for governing the region. , The medal is ...
(Date:7/30/2014)... pieces is still in its infant stage. But it ... major significance. "Amazingly often, we are findingin addition to ... we found in Baltic amber," explained Bonn paleontologist Professor ... from the Baltic Sea region, which is almost 10,000 ... the coastal regions of Mecklenburg, Poland and Belarus. The ...
Breaking Biology News(10 mins):Chinese mosquitos on the Baltic Sea 2
... is establishing itself as a global leader in forming a ... the city,s plans to adapt to the challenges and opportunities ... report of the New York City Panel on Climate Change ... York Academy of Sciences , outline the measures the city ...
... COLD SPRING HARBOR, N.Y. (Tues., June 1, ... most important and frequently used techniques in RNA analysis. ... by size and quality assessment. Gels are involved ... primer extension, footprinting and analyzing processing reactions. The ...
... 1, 2010 - Elsevier Properties SA announces the winners ... currently studying for a PhD or having completed a ... recognizes research excellence in the fields of organic, organometallic ... after the prize was launched in January 2010. Submissions ...
Cached Biology News:How New York City is preparing for climate change 2How New York City is preparing for climate change 3Electrophoresis of RNA, avian imaging featured in June's Cold Spring Harbor Protocols 2The Reaxys Ph.D. Prize awards innovative research in organic, organometallic and inorganic chemistry 2The Reaxys Ph.D. Prize awards innovative research in organic, organometallic and inorganic chemistry 3
(Date:7/30/2014)... STONY BROOK, NY (PRWEB) July 30, 2014 ... (OTCQB: APDN), (Twitter: @APDN), a biotechnology firm that provides ... Dr. Michael E. Hogan, Ph.D. Vice President of Life ... in mid-September. , Dr. Hogan will lead ... to form business relationships with biotech and healthcare customers, ...
(Date:7/30/2014)... Fla. , July 30, 2014  Dyadic ... biotechnology company whose patented and proprietary technologies are ... and other proteins for the bioenergy, bio-based chemical, ... appointment of Thomas "Tom" Dubinski as Vice President ... for leading the financial and information technology operations ...
(Date:7/30/2014)... July 30, 2014 NCERC at ... will present his findings on corn stover pretreatment ... this week in Washington, D.C. , “Arun’s ... conference is a testament to the success of ... said. “Thanks to the foresight and vision of ...
(Date:7/30/2014)... LayerBio, Inc., an MIT spinoff developing novel ... of seed financing from friends and family investors. Proceeds ... a novel sustained-release product for ophthalmology. , "We are ... commitment to this important work," said Dr. Ken Mandell, ... many areas in which innovations in drug delivery have ...
Breaking Biology Technology:Dr. Michael E. Hogan, Ph.D., Joins Applied DNA Sciences as Vice President, Life Sciences 2Dr. Michael E. Hogan, Ph.D., Joins Applied DNA Sciences as Vice President, Life Sciences 3Thomas Dubinski joins Dyadic as Chief Financial Officer 2Thomas Dubinski joins Dyadic as Chief Financial Officer 3Thomas Dubinski joins Dyadic as Chief Financial Officer 4NCERC at SIUE Researcher Takes Stage at Department of Energy Conference 2NCERC at SIUE Researcher Takes Stage at Department of Energy Conference 3
... Feb. 28 As the leading distributor ... a business,partnership with Spectra Intelligence which allows ... market analyses through the,MarketResearch.com website., The ... world,easy access to complete product descriptions and ...
... Seeks Exclusion Order Barring Importation of CryoCath,s Cryoablation ... Inc. (Nasdaq:,CRYO), a medical device company focused on ... has filed a formal complaint with the,United States ... has engaged in unfair trade practices by infringing ...
... (Nasdaq: KOSN ) today reported financial results for the,quarter ... the quarter and year ended December 31, 2007 were $9.5,million ... to $4.6,million and $29.5 million, or $0.13 and $0.88 per ... were $5.6 million and $22.7 million for the quarter and ...
Cached Biology Technology:MarketResearch.com Announces Distribution of Spectra Intelligence Research 2CryoCor Requests International Trade Commission Investigation Into CryoCath for Patent Infringement 2CryoCor Requests International Trade Commission Investigation Into CryoCath for Patent Infringement 3Kosan Announces Fourth Quarter and Full Year 2007 Financial Results and 2008 Outlook 2Kosan Announces Fourth Quarter and Full Year 2007 Financial Results and 2008 Outlook 3Kosan Announces Fourth Quarter and Full Year 2007 Financial Results and 2008 Outlook 4Kosan Announces Fourth Quarter and Full Year 2007 Financial Results and 2008 Outlook 5Kosan Announces Fourth Quarter and Full Year 2007 Financial Results and 2008 Outlook 6
...
Purified Mouse anti-Hu LAT (pY226) Storage Temperature: Refrigerate(2 to 8C)...
...
... Signets Xylene Resistant (X/R) Red ... Chromogen, X/R Red Activator and X/R ... reacts with alkaline phosphatase to produce ... mounted. ,Kit Contains:, , Buffer, ...
Biology Products: