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Scientists identify novel inhibitor of human microRNA
Date:9/25/2008

rotein. Groups of control cells and untreated cells showed no such signal when treated with the small-molecule inhibitor.

The findings were published in the September 15 issue of the scientific journal Angewandte Chemie.

Preliminary data from the researchers' ongoing studies suggest that the inhibitor could be used in combination with other chemotherapy drugs to provide a synergistic effect, Huang says. The researchers also will evaluate its potential as a stand-alone cancer drug. Huang and his colleagues are now conducting studies in mice to assess the inhibitor's effectiveness against brain, breast, and colon tumors, and they are working to modify the molecule to make it even more efficient.

The screening test developed by the researchers provides a unique tool that can be used to advance investigations of miRNAs and their involvement in various diseases, Huang says. "The cell-based assay that we have established can potentially be used to screen for additional small-molecule inhibitors that can block miRNA," he notes.


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Contact: Abbey J. Porter
aporter@wistar.org
215-898-3943
The Wistar Institute
Source:Eurekalert

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