Navigation Links
Scientists identify natural anti-cancer defenses
Date:12/11/2009

This release is available in French.

Montreal, December 11, 2009 Canadian researchers have discovered a novel molecular mechanism that prevents cancer. In the December 11 edition of the prestigious journal Molecular Cell, scientists from the Universit de Montral and the Universit de Sherbrooke explain how they found that the SOCS1 molecule prevents the cancer-causing activity of cytokines, hormones that are culprits in cancer-prone chronic inflammation diseases such as Crohns, in smokers and people exposed to asbestos.

"Excessive cytokine activity promotes cancer," says Dr. Gerardo Ferbeyre, senior author and a Universit de Montral biochemistry professor. "Discovery of these mechanisms will enable scientists to design a cancer-prevention strategy for people with chronic inflammatory diseases and lead to better understanding of the human body's natural defenses against cancer."

The research team didn't anticipate that SOCS1 would turn out to be linked to p53, the master regulator of natural anticancer defenses. "We were surprised to realize that SOCS1 was directly linked to p53," says first author and Universit de Montral student, Viviane Calabrese.

"Our team showed that SOCS1 is a direct regulator of the p53 gene and that in its absence the p53 pathway is significantly disabled," says Dr. Ferbeyre, noting the p53 gene is frequently lost in human cancer patients as it is SOCS1.

The new research suggests that the effects of SOCS1 loss in patients might also disable the p53 tumor suppression pathway. The research team also showed that the reintroduction of SOCS1 into tumor cells locked them into a permanent dormant state known as cell senescence preventing them from multiplying wildly as is typical of cancer cells. "With this study, we provide new hope of finding a treatment to activate natural anticancer defens
'/>"/>

Contact: Sylvain-Jacques Desjardins
sylvain-jacques.desjardins@umontreal.ca
514-343-7593
University of Montreal
Source:Eurekalert

Page: 1 2

Related biology news :

1. UK scientists working to help cut ID theft
2. Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
3. Comet probes reveal evidence of origin of life, scientists claim
4. Scientists link fragile X tremor/ataxia syndrome to binding protein in RNA
5. Male elephants get photo IDs from scientists
6. Scientists retrace evolution with first atomic structure of an ancient protein
7. Muscle mass: Scientists identify novel mode of transcriptional regulation during myogenesis
8. Carnegie Mellon scientists develop nanogels that enable controlled delivery of carbohydrate drugs
9. Clemson scientists shed light on molecules in living cells
10. Scientists tackle mystery mountain illness
11. T. rex quicker than Becks, say scientists
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/15/2014)... Mass. (September 15, 2014) The so-called central ... makes proteinhas long provided a simplified explanation for ... living organisms. , In reality, of course, ... schema first articulated nearly 60 years ago by ... double-helix structure. For one, there are multiple types ...
(Date:9/15/2014)... cell division has evolved a simple, mechanical solution ... the Sept. 11 Science Express. ... counts and misalignments that lead to infertility, miscarriage, ... cell division cause these problems, but what exactly ... Marston of the Wellcome Trust Center for Cell ...
(Date:9/15/2014)... that a single group of microorganisms may be responsible ... the oceans, with implications for the global carbon cycle ... essential molecule required by most life on this planet, ... of microorganisms because it is so large and complex. ... maintaining the brain and nervous systems, as well as ...
Breaking Biology News(10 mins):Scientists discover RNA modifications in some unexpected places 2Cells simply avoid chromosome confusion 2Cells simply avoid chromosome confusion 3Researchers discover new producer of crucial vitamin 2
... to play in urgently-needed new treatments to fight the virulent ... Strathclyde in Glasgow, Scotland. The scientists found that ... in the Pacific region, was active against MRSA, which causes ... was either the underlying cause or a contributory factor in ...
... have developed a way of accurately predicting when women will ... difference between the predicted age and the actual age that ... a third of a year, and the maximum margin of ... Ramezani Tehrani will tell the 26th annual meeting of the ...
... new technology that allows scientists to monitor how individual cells ... researchers have uncovered a much larger spectrum of differences between ... act in a uniform fashion, as was previously thought. ... Markus Covert, PhD, assistant professor of bioengineering and senior author ...
Cached Biology News:Bees help to beat MRSA bugs 2Researchers develop accurate way to predict the age when women will hit the menopause 2Researchers develop accurate way to predict the age when women will hit the menopause 3Same types of cell respond differently to stimulus, Stanford study shows 2Same types of cell respond differently to stimulus, Stanford study shows 3
(Date:9/16/2014)... 2014 BlueInGreen® , a ... method for delivering dissolved gases into liquids, announced ... as a manufacturer’s representative firm to its sales ... for municipal water and wastewater applications in the ... was founded in 1992 and serves Quebec and ...
(Date:9/16/2014)... 16, 2014 CIRTEC Medical Systems’ Board ... as CEO of CIRTEC. , “I am delighted ... the Company.” noted Brian Highley. “The company has made ... strong organic growth over the past two years. The ... to improve and expand the services Cirtec offers its ...
(Date:9/16/2014)... (PRWEB) September 16, 2014 ... initiatives to position themselves for their 89th ... labeling and encoding, Pharma Packaging Solutions is ... hardware and software and new procedures. Establishing ... Good Manufacturing Practices (cGMP), Pharma Packaging Solutions ...
(Date:9/16/2014)... Calif. , Sept. 16, 2014 /PRNewswire-iReach/ -- ... index (BMSi) test identifies patients with bone fragility ... Over 160 million people worldwide are at risk ... by today,s standard bone strength test, the DEXA ... 2014 American Society for Bone and Mineral Research ...
Breaking Biology Technology:BlueInGreen® Expands into Canada – Signs Representative Agreement with H2Flow Equipment Inc. 2Adding Serialization Capabilities and Expanded Capacity, Pharma Packaging Solutions Is Preparing for 89th Year of Business 2ActiveLife's BMSi Test Provides Hope for 160 Million with Undetectable Risk of Bone Fracture 2ActiveLife's BMSi Test Provides Hope for 160 Million with Undetectable Risk of Bone Fracture 3
... In light of an announcement made recently by Astellas Pharma ... that it had received a letter dated November 13, 2008 ... acquire CV Therapeutics at a price of $16.00 per share, ... After careful deliberation, with the assistance of its financial ...
... Alfacell Corporation (OTC Bulletin Board: ACEL) today reported that ... Food and Drug Administration (FDA) to discuss the company,s ... rolling New Drug Application (NDA) for the treatment of ... meeting, the FDA provided guidance to the company recommending ...
... Conference Call and Webcast Scheduled for Tuesday, February 3, ... (Nasdaq: NBIX ) announced today that the ... financial results after the Nasdaq market closes on Tuesday, ... conference call and webcast to discuss its financial results ...
Cached Biology Technology:CV Therapeutics Statement on Unsolicited Proposal From Astellas 2CV Therapeutics Statement on Unsolicited Proposal From Astellas 3Alfacell Provides ONCONASE(R) NDA Submission Update 2Alfacell Provides ONCONASE(R) NDA Submission Update 3Neurocrine Biosciences Announces Conference Call and Webcast to Present Fourth Quarter and Year End 2008 Financial Results 2
Goat polyclonal to Duffy / FY / DARC...
SMVT (N-14)...
... Description: Proteinase K is a ... wide range of applications purified from the fungus ... the carboxyl group of N-substituted hydrophobic aliphatic and ... as a serine protease. Proteinase K is useful ...
... The H2OBIT™ is a fully licensed, high throughput, ... processing of up to 24 microplates. This equates ... plates. A robotic arm rapidly transfers ... resulting in temperature ramping times that are considerably ...
Biology Products: