Navigation Links
Scientists identify molecular system that could help develop treatments for Alzheimer's disease
Date:2/21/2013

Scientists from the University of Southampton have identified the molecular system that contributes to the harmful inflammatory reaction in the brain during neurodegenerative diseases.

An important aspect of chronic neurodegenerative diseases, such as Alzheimer's, Parkinson's, Huntington's or prion disease, is the generation of an innate inflammatory reaction within the brain.

Results from the study open new avenues for the regulation of the inflammatory reaction and provide new insights into the understanding of the biology of microglial cells, which play a leading role in the development and maintenance of this reaction.

Dr Diego Gomez-Nicola, from the CNS Inflammation group at the University of Southampton and lead author of the paper, says: "The understanding of microglial biology during neurodegenerative diseases is crucial for the development of potential therapeutic approaches to control the harmful inflammatory reaction. These potential interventions could modify or arrest neurodegenerative diseases like Alzheimer disease.

"The future potential outcomes of this line of research would be rapidly translated into the clinics of neuropathology, and would improve the quality of life of patients with these diseases."

Microglial cells multiply during different neurodegenerative conditions, although little is known about to what extent this accounts for the expansion of the microglial population during the development of the disease or how it is regulated.

Writing in The Journal of Neuroscience, scientists from the University of Southampton describe how they used a laboratory model of neurodegeneration (murine prion disease), to understand the brain's response to microglial proliferation and dissected the molecules regulating this process. They found that signalling through a receptor called CSF1R is a key for the expansion of the microglial population and therefore drugs could target this.

Dr Diego Gomez-Nicola adds: "We have been able to identify that this molecular system is active in human Alzheimer's disease and variant CreutzfeldtJakob disease, pointing to this mechanism being universal for controlling microglial proliferation during neurodegeneration. By means of targeting CSF1R with selective inhibitors we have been able to delay the clinical symptoms of experimental prion disease, also preventing the loss of neurons."


'/>"/>

Contact: Glenn Harris
G.Harris@soton.ac.uk
44-023-805-93212
University of Southampton
Source:Eurekalert  

Related biology news :

1. Scientists publish analysis of algae parasite impact on algae biofuel in PLOS ONE
2. UCLA scientists develop new therapeutics that could accelerate wound healing
3. Insects scientists and children meeting in Las Cruces, New Mexico
4. Brown University scientists to discuss resilience of coastal communities at AAAS
5. Going negative: Stanford scientists explore new technologies that remove atmospheric CO2
6. Biodiversity protects against disease, scientists find
7. Scientists develop improved fire management tools for Africas savannas
8. NTU Provost receives prestigious Imperial College fellowship joining the ranks of top UK scientists
9. Southern insect scientists to meet in Baton Rouge in March
10. Scientists discover how animals taste, and avoid, high salt concentrations
11. Mainz scientists confirm original tetrahedral model of the molecular structure of water
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists identify molecular system that could help develop treatments for Alzheimer's disease
(Date:5/12/2016)... WearablesResearch.com , a brand of Troubadour Research & ... Q1 wave of its quarterly wearables survey. A particular ... a program where they would receive discounts for sharing ... "We were surprised to see that so many ... CEO of Troubadour Research, "primarily because there are segments ...
(Date:4/26/2016)... and LONDON , April ... part of EdgeVerve Systems, a product subsidiary of ... today announced a partnership to integrate the Onegini ...      (Logo: http://photos.prnewswire.com/prnh/20151104/283829LOGO ) ... their customers enhanced security to access and transact ...
(Date:4/14/2016)... 2016 BioCatch ™, the ... announced the appointment of Eyal Goldwerger as ... Goldwerger,s leadership appointment comes at a time of ... deployment of its platform at several of the world,s ... discerns unique cognitive and physiological factors, is a winner ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... 23, 2016 Apellis Pharmaceuticals, Inc. today ... trials of its complement C3 inhibitor, APL-2. The ... ascending dose studies designed to assess the safety, ... injection in healthy adult volunteers. Forty ... a single dose (ranging from 45 to 1,440mg) ...
(Date:6/23/2016)... NEW YORK , June 23, 2016 ... the trading session at 4,833.32, down 0.22%; the Dow Jones ... the S&P 500 closed at 2,085.45, down 0.17%. Stock-Callers.com has ... INFI ), Nektar Therapeutics (NASDAQ: NKTR ... BIND Therapeutics Inc. (NASDAQ: BIND ). Learn more ...
(Date:6/23/2016)... ... June 23, 2016 , ... Velocity Products, ... tools designed, tuned and optimized exclusively for Okuma CNC machining centers at The ... of a collaboration among several companies with expertise in toolholding, cutting tools, machining ...
(Date:6/22/2016)... , June 22, 2016 Cell ... will allow them to produce up to one ... one lot within one week. These high-quality, consistent ... laboriously preparing cells and spend more time doing ... through a proprietary, high-volume manufacturing process that produces ...
Breaking Biology Technology: