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Scientists identify 'long distance scanner' for DNA damage
Date:2/19/2014

detected.

Researchers from the University of Bristol's School of Biochemistry have now shown that a molecular motor protein called Mfd - the first helper to be attracted by RNA polymerase when it gets into difficulties - acts as a long distance scanner for DNA damage.

Professor Nigel Savery, who led the group, said "Our results show that the method for detecting DNA damage within active genes is more sophisticated than expected. The pathway that links DNA repair to gene expression has the potential to act over much greater distances than previously thought, because once it has been loaded onto the DNA by an RNA polymerase this first-response motor protein travels for hundreds of base pairs - the building blocks of the DNA double helix - in search of damage.

"Our work also provides the first indication that sequences of DNA where RNA polymerases briefly slow down and pause may be acting as signals for the DNA repair proteins to scrutinise the neighbouring DNA particularly carefully."


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Contact: Philippa Walker
philippa.walker@bristol.ac.uk
44-117-928-8086
University of Bristol
Source:Eurekalert

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