Navigation Links
Scientists identify how virus triggers cervical and mouth cancer
Date:12/14/2010

University of Manchester scientists have discovered for the first time an important new way in which the human papilloma virus (HPV) triggers cancer in what could lead to new treatments for cervical and mouth cancer.

HPV infection is known to increase the risk of developing cancers of the cervix and mouth with the two high-risk forms of the virus accounting for approximately 70% of all cervical cancer cases.

Vaccinations against these high-risk forms of HPV should reduce the incidence of cervical cancer but the frequency of mouth cancer actually increased in the UK by about 50% between 1989 and 2007, a trend that seems to be accelerating.

If the current vaccines prove effective at preventing oral HPV infection, the authors claim their findings provide additional justification for the current programme of vaccinating young girls and may also lend support to extending the programme to young boys too.

"Scientists have known for some years about the link between HPV and certain cancers but the biological processes involved are not fully understood," said Dr Ian Hampson, who with wife Dr Lynne Hampson headed the research. "Our latest results shed new light on this.

"Our study has shown that a protein in cells called Cdc42, which is already known to be implicated in a number of cancers as well as in tumour spread, is inappropriately activated by the human papilloma virus.

"The findings are important since it is essential to increase our understanding of how the virus causes the disease if we are to design new approaches for the prevention or treatment of HPV-related cancers. Mouth cancer, in particular, is notoriously difficult to treat and often leads to long-term disability.

"If the vaccination programme is shown to reduce the incidence of oral HPV infection then this study would appear to support its continued use as a way to prevent HPV-related mouth cancer and perhaps consideration should be given to
'/>"/>

Contact: Aeron Haworth
aeron.haworth@manchester.ac.uk
44-161-275-8383
University of Manchester
Source:Eurekalert

Page: 1 2

Related biology news :

1. Scientists unravel more details of plant cell-wall construction
2. Team of scientists predicts continued death of forests in southwestern US due to climate change
3. UCR scientists identify pomegranate juice components that could stop cancer from spreading
4. National team of scientists peers into the future of stem cell biology
5. Scientists begin 5-month study of cloud life cycles
6. UC San Diego computer scientists lauded for computer systems security, bioinformatics work
7. Reproductive scientists create mice from 2 fathers
8. Life thrives in porous rock deep beneath the seafloor, scientists say
9. Scientists announce discovery of first horned dinosaur from South Korea
10. Fledgling ecosystem at Chicken Creek lets scientists observe how soil, flora and fauna develop
11. Scientists find gene linked to congenital heart defect
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/29/2014)... sometimes need to get back to basics. UC ... study the impacts of the bumphead parrotfish ( ... two remote locations in the central Pacific Ocean. ... simulation, McCauley, an assistant professor in the Department ... colleagues sought to understand whether the world,s largest ...
(Date:7/29/2014)... effects of a stroke is an immensely complex ... well as effective therapy. Advancing such knowledge to ... primary focus of research by Sergei Adamovich, associate ... NJIT faculty more than a decade ago. It ... funding from sources such as the National Institutes ...
(Date:7/29/2014)... (UM SOD) and Medicine (UM SOM) jointly announced ... million grant award from the National Institute of ... Institutes of Health to study the causes, prevention ... which renews a previous $12 million five-year NIAID-funded ... research by studying chlamydial and gonorrheal diseases as ...
Breaking Biology News(10 mins):Underwater elephants 2Underwater elephants 3Continuing the quest for better stroke therapies 2Continuing the quest for better stroke therapies 3University of Maryland Schools of Dentistry and Medicine receive NIH grant 2University of Maryland Schools of Dentistry and Medicine receive NIH grant 3University of Maryland Schools of Dentistry and Medicine receive NIH grant 4
... islet cells from pigs may be used in clinical ... diabetes. This key finding was the discovery ... Institute for Immunology & Transplantation at the University of ... in the prestigious scientific journal Nature Medicine in March ...
... MICROSCOPY -- A chorus of signals . . . ... scanning probe microscopy, moves the field towards probing energy ... probe microscopes measure the cantilevers movements over the surface ... excitation excites and detects response over a continuous band ...
... of UPMC have identified a potential target for ... the most prevalent sexually transmitted bacterial infection in ... Darville, MD, chief of the Division of Pediatric ... of Chlamydia that, when investigated in an animal ...
Cached Biology News:Breakthrough research identifies how cells from pigs may cure diabetes 2Story tips from the US Department of Energy's Oak Ridge National Laboratory, September 2007 2Story tips from the US Department of Energy's Oak Ridge National Laboratory, September 2007 3Study by Pittsburgh researchers identifies possible vaccine target for chlamydia 2
(Date:7/29/2014)... July 29, 2014 According to ... Slide Imaging), Analytics (Image Analysis Software), Delivery Modes (Web ... Forecasts & Trends to 2018", published by MarketsandMarkets, analyzes ... geographies such as North America , ... , and the Rest of the World (RoW). ...
(Date:7/29/2014)... 2014 /PRNewswire-iReach/ -- Nanosyn, Inc. announced today a ... to provide access to Nanosyn,s microfluidics screening and ... for novel small molecule therapeutics. ... work with FORMA Therapeutics to explore key pathways ... FORMA Therapeutics, decision to work with us is ...
(Date:7/29/2014)... Colo. , July 29, 2014  Cannabis ... in cannabis formulation-based drug development and related consulting, ... Times for taking a strong position in opposition ... Sunday, July 27, 2014 publication.  The New York ... and articles this week exploring the issue called ...
(Date:7/29/2014)... Denver, CO (PRWEB) July 29, 2014 ... and soiled linen collection and transport solutions for hospitals, ... Society for Healthcare Engineering (ASHE) Annual Conference & Technical ... TransVac will present its technology for making hospitals cleaner, ... operational costs over the hospital’s life cycle. Staff ...
Breaking Biology Technology:Digital Pathology Market worth $437 Million by 2018 2Digital Pathology Market worth $437 Million by 2018 3Nanosyn Announces Expanded Partnership With FORMA Therapeutics 2Cannabis Science, Inc. (CBIS) Applauds New York Times Editorial Board Stance on 'Repealing Prohibition, Again'; NYT Editorial Is Bell Weather of Change 2Cannabis Science, Inc. (CBIS) Applauds New York Times Editorial Board Stance on 'Repealing Prohibition, Again'; NYT Editorial Is Bell Weather of Change 3TransVac Presents Cost Saving Technology at ASHE Conference for Keeping Hospitals Cleaner 2
... LOUIS, Jan. 24 The National Academy of,Sciences ... Fraley, Ph.D.,chief technology officer and executive vice president ... the Industrial Application of Science. This,prize is awarded ... importance and with significant, beneficial applications in,industry -- ...
... Bard, professor of chemistry and biochemistry at The University ... Prize in Chemistry jointly with Professor William Moerner of ... of education, Professor Yuli Tamir, was given to the ... of science, single-molecule spectroscopy and imaging. , The $100,000 ...
... million grows 32% year-over-year, - Operating income increases 47.7%, diluted ... - Backlog increases 41% to a record of ... - Net quarterly book-to-burn ratio equates to 1.9, BOSTON, ... its financial results for the,second quarter ended December 31, 2007., ...
Cached Biology Technology:National Academy of Sciences Recognizes Monsanto's Chief Technology Officer for Development of Agricultural Biotechnology 2PAREXEL Reports Second Quarter Fiscal Year 2008 Financial Results 2PAREXEL Reports Second Quarter Fiscal Year 2008 Financial Results 3PAREXEL Reports Second Quarter Fiscal Year 2008 Financial Results 4PAREXEL Reports Second Quarter Fiscal Year 2008 Financial Results 5PAREXEL Reports Second Quarter Fiscal Year 2008 Financial Results 6PAREXEL Reports Second Quarter Fiscal Year 2008 Financial Results 7PAREXEL Reports Second Quarter Fiscal Year 2008 Financial Results 8PAREXEL Reports Second Quarter Fiscal Year 2008 Financial Results 9PAREXEL Reports Second Quarter Fiscal Year 2008 Financial Results 10
Anti-Kusabira Orange Monoclonal Antibody Description: 100 g Research Focus: tag Storage: -20C Shipping Temperature: 4C...
Anti-Kusabira Orange Monoclonal Antibody Description: 100 g Research Focus: tag Storage: -20C Shipping Temperature: 4C...
Rabbit anti-NFkB p105/p50 (Ser337) Class: Antibody Product Group: Signalling molecules and phospho-specific Antibody...
Anti-Kusabira Orange Monoclonal Antibody Description: 100 g Research Focus: tag Storage: -20C Shipping Temperature: 4C...
Biology Products: