Navigation Links
Scientists identify how virus triggers cervical and mouth cancer
Date:12/14/2010

University of Manchester scientists have discovered for the first time an important new way in which the human papilloma virus (HPV) triggers cancer in what could lead to new treatments for cervical and mouth cancer.

HPV infection is known to increase the risk of developing cancers of the cervix and mouth with the two high-risk forms of the virus accounting for approximately 70% of all cervical cancer cases.

Vaccinations against these high-risk forms of HPV should reduce the incidence of cervical cancer but the frequency of mouth cancer actually increased in the UK by about 50% between 1989 and 2007, a trend that seems to be accelerating.

If the current vaccines prove effective at preventing oral HPV infection, the authors claim their findings provide additional justification for the current programme of vaccinating young girls and may also lend support to extending the programme to young boys too.

"Scientists have known for some years about the link between HPV and certain cancers but the biological processes involved are not fully understood," said Dr Ian Hampson, who with wife Dr Lynne Hampson headed the research. "Our latest results shed new light on this.

"Our study has shown that a protein in cells called Cdc42, which is already known to be implicated in a number of cancers as well as in tumour spread, is inappropriately activated by the human papilloma virus.

"The findings are important since it is essential to increase our understanding of how the virus causes the disease if we are to design new approaches for the prevention or treatment of HPV-related cancers. Mouth cancer, in particular, is notoriously difficult to treat and often leads to long-term disability.

"If the vaccination programme is shown to reduce the incidence of oral HPV infection then this study would appear to support its continued use as a way to prevent HPV-related mouth cancer and perhaps consideration should be given to
'/>"/>

Contact: Aeron Haworth
aeron.haworth@manchester.ac.uk
44-161-275-8383
University of Manchester
Source:Eurekalert

Page: 1 2

Related biology news :

1. Scientists unravel more details of plant cell-wall construction
2. Team of scientists predicts continued death of forests in southwestern US due to climate change
3. UCR scientists identify pomegranate juice components that could stop cancer from spreading
4. National team of scientists peers into the future of stem cell biology
5. Scientists begin 5-month study of cloud life cycles
6. UC San Diego computer scientists lauded for computer systems security, bioinformatics work
7. Reproductive scientists create mice from 2 fathers
8. Life thrives in porous rock deep beneath the seafloor, scientists say
9. Scientists announce discovery of first horned dinosaur from South Korea
10. Fledgling ecosystem at Chicken Creek lets scientists observe how soil, flora and fauna develop
11. Scientists find gene linked to congenital heart defect
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/22/2014)... In contrast to their negative reputation as disease ... and evolutionary functions that help to shape the ... new report by the American Academy of Microbiology. ... influence all life forms on the planet, from ... and driving major speciation events," states Marilyn Roossinck ...
(Date:7/22/2014)... N.C. In a cost-effectiveness analysis of commercial diet ... drug Qsymia showed the best value for the money. ... but was also the most expensive option tested, according ... Medical School. , The findings, published in the June ... information on the health and weight-loss benefits per dollar ...
(Date:7/22/2014)... China July 22, 2014 BGI Tech ... BGI, the world,s largest genomics organization, announced today ... exome sequencing service based on Complete Genomics, industry-leading ... analysis and SNP validation, and is available at ... Complete Genomics, highly regarded in the industry for ...
Breaking Biology News(10 mins):Report on viruses looks beyond disease 2Study compares cost-effectiveness of weight-loss programs and drugs 2Study compares cost-effectiveness of weight-loss programs and drugs 3BGI Tech launches human whole exome sequencing service on complete genomics' advanced platform 2
... has always depended on harvesting from nature for food ... for technological ideas. Indeed, the guiding principle behind ... evolutionary process has already performed innumerable experiments over many ... Cheryl Hayashi will give a free public ...
... a stubby tail: an odd-looking mouse discovered through a U.S. government ... and an extra set of ribs in its neck and ... at the University of California, San Francisco has now spilled the ... have uncovered a new wrinkle in the genetic code an ...
... the Max Planck Society (MPG; President Peter ,Gruss) signed ... collaboration by ,establishing a joint research center for systems ... systematic understanding of biological systems from a chemistry perspective. ... together the RIKEN Advanced Science Institute,s ,natural chemical compounds ...
Cached Biology News:How nature's best ideas inspire innovative new technologies 2Mutant mouse reveals new wrinkle in genetic code, say UCSF scientists 2Mutant mouse reveals new wrinkle in genetic code, say UCSF scientists 3
(Date:7/22/2014)... The DNA Spectrum Ancestry ... representation of history, migration, and culture. , Throughout ... family history stories stemming from Europe. His father passionately ... Pictures and 8mm home movies painted an elaborate picture ... and Steve ordered a test from DNA Spectrum to ...
(Date:7/22/2014)... SHENZHEN , Kina, 22. juli 2014 /PRNewswire/ ... et datterselskab af BGI, verdens største genomics-organisation, annoncerede ... exome-sekvenseringstjeneste baseret på Complete Genomics brancheførende platform. ... for at levere patenterede sekvenseringsteknologier med 99,999 % ... blev købt af BGI i 2013. Mere end ...
(Date:7/22/2014)... Hussey Copper , a leader in copper manufacturing ... Pullman Regional Hospital,s conversion of more than 1,100 touch ... at a nominal cost.  This reasonably priced surface kills ... within 2 hours of exposure 1 and will aid ... in its facilities. Pullman Regional Hospital, in ...
(Date:7/22/2014)... July 22, 2014 Quorum Review IRB, the ... for large clinical trials called Quick Step™ . The ... to address the research industry’s need for seamless study start-up ... is available for studies planning 50 or more North American ... planned North American site count of 80 or more. Qualifying ...
Breaking Biology Technology:DNA Test from DNA Spectrum Shows Heritage Like a Map of the Past 2DNA Test from DNA Spectrum Shows Heritage Like a Map of the Past 3DNA Test from DNA Spectrum Shows Heritage Like a Map of the Past 4BGI Tech lancerer Human Whole Exome-sekvenseringstjeneste på Complete Genomics avancerede platform 2Pullman Regional Hospital changes more than 1,100 touch points to Hussey Copper's MD-Cu29 antimicrobial copper to help protect against bacteria 2Pullman Regional Hospital changes more than 1,100 touch points to Hussey Copper's MD-Cu29 antimicrobial copper to help protect against bacteria 3Quorum Review IRB Launches New Quick Step™ Service for Large Clinical Trials 2Quorum Review IRB Launches New Quick Step™ Service for Large Clinical Trials 3
... N.Y. Whoever penned the old adage "a watched pot ... a pot lined with copper nanorods. , A new study ... an invisible layer of the nanomaterials to the bottom of ... required to bring water to boil. This increase in efficiency ...
... of Standards and Technology (NIST) have developed a ... magnetic materials such as nickel or nickel-iron alloys ... process, described in a recent paper,* could enable ... devices. , The NIST team also demonstrated that ...
... Inc.,("Dragon Pharma" or the "Company" TSX: DDD; OTCBB: ... announced the results,of the Annual Shareholders Meeting held ... were 48,663,865 shares equaling 69.81% of the outstanding ... following,eight persons to serve as members of the ...
Cached Biology Technology:On the boil: New nano technique significantly boosts boiling efficiency 2On the boil: New nano technique significantly boosts boiling efficiency 3New process creates 3-D nanostructures with magnetic materials 2
BD BioCoat Matrigel Matrix 35 mm Culture Dishes Coating : BD MatrigelTM Basement Membrane Matrix ,Surface : ECM/attachment factors ,Surface area : 9.6 cm2 ,Dim nominal : 35 mm x 10 mm ,Vo...
BD BioCoat Fibronectin 35 mm Culture Dishes, tissue-culture treated polystyrene with a uniform application of human fibronectin....
... to Human Cytokeratin TYPE II Reacts ... keratins. Including epidermal cell keratin of 86 ... and 67kD. Broad keratin reactivity is found ... Immunogen: Human epidermal ...
BD BioCoat Fibronectin 150 mm Culture Dishes...
Biology Products: