Navigation Links
Scientists identify gene crucial to normal development of lungs and brain
Date:1/12/2012

La Jolla ---- Scientists at the Salk Institute for Biological Studies have identified a gene that tells cells to develop multiple cilia, tiny hair-like structures that move fluids through the lungs and brain. The finding may help scientists generate new therapies that use stem cells to replace damaged tissues in the lung and other organs.

"Cells with multiple cilia play a number of important roles, including moving fluids through the respiratory tract, brain and spinal cord," says Christopher R. Kintner, a professor in Salk's Molecular Neurobiology Laboratory, who led the research. "Knowing the gene that instructs cells to develop multiple cilia helps us understand how we might coax stem cells into developing into this type of cell, which we could then use to repair damaged tissue."

The findings of the research, which was supported by the National Institutes of Health and Salk's Innovation Grants Program, were published in the January 8 online issue of Nature Cell Biology.

Kintner and his collaborator, Jennifer Stubbs, a scientist now at Pathway Genomics, a San Diego biotech company, along with Eszter Vladar, a postdoctoral fellow in the laboratory of Jeffery Axelrod, at the Stanford University School of Medicine, made their discovery by initially studying the embryos of African clawed frogs (Xenopus laevis).

Multiciliate cells form on the outside of the embryos, making them easy to study, and the genetic mechanisms that direct the frog cells to develop multiple cilia are likely similar to those of humans.

Humans and other organisms inherited cilia from our single-celled primordial ancestors that used these beating structures as a form of propulsion. Most cells in our body project a single, non-moving cilium used as a tiny antenna for detecting chemical and physical stimuli. But certain specialized tissues require cells with 100 to 200 moving cilia that beat in concert to move fluids through the body.'/>"/>

Contact: Andy Hoang
ahoang@salk.edu
619-861-5811
Salk Institute
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Scientists look to microbes to unlock Earths deep secrets
2. Nobel history illustrates gap in grants to young scientists
3. Damon Runyon grants Fellowship and Breakthrough Scientist awards to 21 top young scientists
4. UCSB scientists say topography played key role in Deepwater Horizon disaster
5. Illinois scientists link dietary DHA to male fertility
6. Scientists refute Greenpeace claim that genetically modified corn caused new insect pest
7. Scientists characterize protein essential to survival of malaria parasite
8. University scientists aiding fishermen in butterfish conundrum
9. Salk scientists map the frontiers of vision
10. UGA scientists hijack bacterial immune system
11. Scripps Research scientists discover a brain cell malfunction in schizophrenia
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists identify gene crucial to normal development of lungs and brain
(Date:7/24/2014)... on different species of fish, according to a ... Exeter which tested fish anti-predator behaviour. , ... predator model when exposed to additional noise, whereas ... , Lead author Dr Irene Voellmy of Bristol,s ... many aquatic environments have increased substantially during the ...
(Date:7/24/2014)... terroir, meaning the microbial populations found on surfaces in ... the final flavor according to research published ahead of ... . This is the first time investigators have taken ... Many sake makers inoculate with both bacteria and yeast, ... of California, Davis, but he and his colleagues investigated ...
(Date:7/24/2014)... at NJIT this week for an all-day public forum ... Protection Agency (EPA) to dredge toxic sediment from an ... EPA has called the plan, which proposes removing 4.3 ... of the riverbed, one of the largest cleanups in ... and disposed off-site. , "We need to ensure the ...
Breaking Biology News(10 mins):The microbes make the sake brewery 2Experts Weigh the Pros and Cons of a $1.7 Billion EPA Cleanup Plan for the Passaic River at an NJIT 2
... scientists survey five New York flu seasons , On the ... for Genomic Research (TIGR) have captured influenza evolution in action. ... , the researchers report the first large-scale project to sequence ... the rapidly evolving flu virus in a human population--and a ...
... RNA is enough to clearly distinguish cancerous thyroid tissue ... findings provide more evidence that an emerging set of ... force in the development of cancer and other diseases. ... Proceedings of the National Academy of Sciences. , Scientists ...
... UK have one of the highest rates of resistance to ... a second wave epidemic of resistant virus, a new study ... concerned that the large reductions in deaths and improvements to ... (combination antiretroviral therapy) may be compromised because of this. , ...
Cached Biology News:First big influenza genome study reveals flu evolution 2First big influenza genome study reveals flu evolution 3First big influenza genome study reveals flu evolution 4Role of microRNA identified in thyroid cancer 2Role of microRNA identified in thyroid cancer 3HIV drug resistance increasing in UK and among highest in the world 2
(Date:7/24/2014)... (PRWEB) July 24, 2014 Your ... advances in modeling lithium-ion battery storage capacity. , ... from a theoretical model created at Lawrence ... that predicts how carbon components will perform ... storage emphasizes the urgent need for higher-performance batteries. ...
(Date:7/24/2014)... San Francisco, CA (PRWEB) July 24, 2014 ... Wednesday to be semi-finalists in Livestrong’s Big C Competition. ... Decisive Health are each headed to the semi-final round. ... in Livestrong’s exclusive three-month accelerator program, complete with mentoring ... country. , As part of the angelMD commitment ...
(Date:7/24/2014)... , July 24, 2014 WIRB-Copernicus Group ... regulatory and ethical review services for clinical research, ... Formerly a division of Richmond, VA ... leading biosafety and biosecurity consulting firm in ... addition, WCG,s biosafety division – WCG Biosafety™ – ...
(Date:7/24/2014)... 24, 2014 Draper University, a ... proud to announce that for 6 weeks this ... will converge on the Draper University campus in ... experiential program focused on entrepreneurship, building real-world skills, ... currently running its sixth cohort, continues to refresh ...
Breaking Biology Technology:Getting More Life out of Lithium-ion Batteries 23 angelMD Startups Make Livestrong Big C Semi-finals 2WIRB-Copernicus Group Announces Acquisition of Alliance Biosciences; Executives Join WCG Biosafety Division 2WIRB-Copernicus Group Announces Acquisition of Alliance Biosciences; Executives Join WCG Biosafety Division 3Summer Entrepreneurship Program Kicked Off by Draper University in Silicon Valley 2Summer Entrepreneurship Program Kicked Off by Draper University in Silicon Valley 3
... Space Place , the University of Wisconsin-Madison's astronomy ... Villager Mall, opening Sunday, Aug. 28. Opening week activities continue ... the public. , ,"We had pretty much outgrown our ... Jim Lattis. "Our programming, our attendance has increased steadily every ...
... aside, every biologist knows that men and women truly are ... where those differences come to the fore: around 80 percent ... play behaviors also differ greatly between the sexes - just ... , ,Early in human development, critical brain proteins known as ...
... Technologies, a life sciences nanotechnology company, has received a ... Medical Sciences. , ,The Small Business Innovation Research grant ... crystal based technology to enable faster screening of drugs ... by using liquid crystals to measure topography on a ...
Cached Biology Technology:Space Place opens new astronomy center 2Gender hormones may lend to social disorder therapies 2
... Lines ,High Quality, Functionally-Validated, Ion Channel Cell ... for having a critical role in nerve ... key function in pain, CNS and the ... been investigated in therapeutic areas, such as ...
Mouse monoclonal antibody raised against a partial recombinant TTC3. NCBI Entrez Gene ID = TTC3...
Mouse polyclonal antibody raised against a partial recombinant SYT4. NCBI Entrez Gene ID = 6860...
Mouse monoclonal antibody raised against a partial recombinant IL31RA. NCBI Entrez Gene ID = IL31RA...
Biology Products: