Navigation Links
Scientists identify first gene in programmed axon degeneration
Date:6/7/2012

WORCESTER, MA Degeneration of the axon and synapse, the slender projection through which neurons transmit electrical impulses to neighboring cells, is a hallmark of some of the most crippling neurodegenerative and brain diseases such as amyotrophic lateral sclerosis (ALS), Huntington's disease and peripheral neuropathy. Scientists have worked for decades to understand axonal degeneration and its relation to these diseases. Now, researchers at the University of Massachusetts Medical School are the first to describe a gene dSarm/Sarm1 responsible for actively promoting axon destruction after injury. The research, published today online by Science, provides evidence of an exciting new therapeutic target that could be used to delay or even stop axon decay.

"This discovery has the potential to have a profound impact on our understanding of neurodegenerative diseases, much like the discovery of apoptosis (programmed cell death) fundamentally changed our understanding of cancer," said Marc R. Freeman, PhD, associate professor of neurobiology at the University of Massachusetts Medical School and lead investigator on the study. "Identification of this gene allows us to start asking exciting new questions about the role of axon death in neurodegenerative diseases. For example, is it possible that these pathways are being inappropriately activated to cause premature axon death?"

For more than a century, scientists believed that injured axons severed from the neuron cell body passively wasted away due to a lack of nutrients. However, a mouse mutation identified in the early 1990s called slow Wallerian degeneration (Wlds) was able to suppress axon degeneration for weeks. This finding forced scientists to reassess Wallerian degeneration, the process through which an injured axon degenerates, as a passive process and consider the possibility that an active program of axon auto-destruction, akin to apoptotic death, was at work instead.

I
'/>"/>

Contact: Jim Fessenden
james.fessenden@umassmed.edu
508-856-2000
University of Massachusetts Medical School
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. UC Davis scientists find new role for P53 genetic mutation -- initiation of prostate cancer
2. OU scientists and international team deciper the genetic code of the tomato
3. Scientists discover a new sensory organ in the chin of baleen whales
4. Scientists start explaining Fat Bastards vicious cycle
5. Scientists find gold-plated fossil solution
6. New study by WHOI scientists provides baseline measurements of carbon in Arctic Ocean
7. Novel discovery by NUS scientists paves the way for more effective treatment of cancers
8. Stanford scientists document fragile land-sea ecological chain
9. Using graphene, scientists develop a less toxic way to rust-proof steel
10. Scripps Florida scientists awarded $8.4 million grant to develop new anti-smoking treatments
11. Berkeley Lab scientists generate electricity from viruses
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... normal circumstances, astrocytes participate in normal physiological ... exhibit therapeutic and repairing effects on brain ... found that nerve cells differentiated from adipose-derived ... viability, which produces influences on subsequent studies ... Hospital, Hebei United University, China demonstrated that ...
(Date:7/11/2014)... Research and Markets has announced ... - Industry Analysis Size Share Growth Trends and Forecast ... http://photos.prnewswire.com/prnh/20130307/600769 The rising ... need for high level security in both private and ... as username and passwords, tokens etc. are vulnerable to ...
(Date:7/11/2014)... brains of all vertebrates, information is transmitted through ... chemical signal to be passed from one brain ... most abundant type of synapse, can be either ... learning, memory, perception and cognition, and the balance ... function. For instance, every time we learn ...
Breaking Biology News(10 mins):International Biometrics Technology Market - Industry Analysis Size Share Growth Trends and Forecast to 2019 2Blame it on the astrocytes 2
... ROCKVILLE, Md. -- The American Society of ... America COMPETES Act. Originally enacted in 2007, ... in Technology, Education, and Science (COMPETES) Act underscored ... technology, engineering, and mathematics education. Among other ...
... surprise to many that quails are able to distinguish one ... quails. Nevertheless, it has long been known that disruption ... group within the UMR 6552 at the CNRS-Universit de Rennes ... on the behavioural development of their offspring. Together with ...
... high quality chocolate, and the farmers who grow it, will ... tree genome, according to an international team led by Claire ... and including scientists from 18 other institutions. The team ... , considered to produce the world,s finest chocolate. The Maya ...
Cached Biology News:Parents' social problems affect their children -- even in birds 2'Food of the gods' genome sequence could make finest chocolate better 2'Food of the gods' genome sequence could make finest chocolate better 3
(Date:7/10/2014)... On July 9 Prime Minister ... Russia,s first national "Industry" award ... is developing a unique project called MabNext . ... number of innovative drugs based on monoclonal antibodies for ... place at the International Exhibition "Innoprom 2014" in Ekaterinburg. ...
(Date:7/10/2014)... , July 10, 2014 Research ... addition of the "International Photonic Integrated Circuit ... Forecasts to 2019" report to their offering. ... The concept of photonic integration traces its ... century. The promise of photonic integration went unexplored ...
(Date:7/10/2014)... research may help in the fight against terrorism with ... quantities of explosives with the use of light and ... Sensors and Actuators B: Chemical , the researchers describe ... in concentrations as low as 6.3 ppm (parts per ... few minutes. , "Traditionally explosives detection has involved looking ...
(Date:7/10/2014)... the basis of psychiatric disorders has been extremely challenging ... risk but are insufficient to cause disease. Now investigators ... Press journal Cell Stem Cell describe a ... risks interact with other risk factors or environmental exposures ... research pinpoints a genetic variant that may predispose individuals ...
Breaking Biology Technology:Dmitry Medvedev Presented BIOCAD the First National "Industry" Award 2International Photonic Integrated Circuit (Monolithic Integration, Hybrid Integration, Module Integration) Market - Forecasts to 2019 2Detecting trace amounts of explosives with light 2New strategy could uncover genes at the root of psychiatric illnesses 2
... Mass., April 2, 2008 Joseph F. Finn,Jr., CPA, ... today the completion of the sale of ActivBiotics intellectual,property ... Rifalazil, a,Phase II antibiotic, 2) a library of novel ... (SODm) and a library of SODm,small molecules., Mr. ...
... Company to Seek Buyer for Marketed Product Ganite(R), Lloyd ... BERKELEY HEIGHTS, N.J., April 2, 2008 Genta,Incorporated ... has,restructured certain of its operations to conserve cash and ... the Company,received notice that its appeal of an adverse ...
... 2008 Pharmaceutical,companies currently challenged with replacing the ... patent in the next four years must dramatically,rethink ... a new report,released by Deloitte today., According ... R&D in the Future,Pharmaceutical Landscape (http://www.deloitte.com/us/FuturePharma ), ...
Cached Biology Technology:Genta Restructures Operations to Focus on Priority Initiatives 2Genta Restructures Operations to Focus on Priority Initiatives 3Genta Restructures Operations to Focus on Priority Initiatives 4As Billions in Blockbuster Drug Revenue Goes Off Patent, Life Sciences Companies are Challenged to Fundamentally Change Future R&D Strategies, According to New Deloitte Report 2As Billions in Blockbuster Drug Revenue Goes Off Patent, Life Sciences Companies are Challenged to Fundamentally Change Future R&D Strategies, According to New Deloitte Report 3
...
... AgarACE Enzyme(a) is a unique agarose-digesting ... quantitative recovery of intact DNA or RNA ... thermostable that low melting point (LMP) agarose ... be equilibrated to the reaction temperature before ...
... Terminal deoxynucleotidyl transferase (TdT) is an ... in cortical thymocytes and minor subpopulation of ... enzyme and increased numbers of TdT cells ... lymphoblastic leukaemias and lymphomas. Presence of TdT ...
Request Info...
Biology Products: