Navigation Links
Scientists identify critical enzyme in healthy heart function
Date:2/19/2010

CINCINNATI Scientists are reporting the first-ever data to show that the enzyme calcineurin is critical in controlling normal development and function of heart cells, and that loss of the protein leads to heart problems and death in genetically modified mice.

Published Feb. 26 in the Journal of Biological Chemistry as the paper of the week, and posted online Feb. 19, the research was led by scientists at Cincinnati Children's Hospital Medical Center and the Howard Hughes Medical Institute.

The study demonstrates that calcineurin in hearts of mice is directly linked to proper cardiac muscle contraction, rhythm and maintenance of heart activity. The near total absence of calcineurin in mice leads to heart arrhythmia, failure and death, according to the research team.

Scientists knew previously that calcineurin is important to heart function, but the extent of its role had not been defined prior to the current study. Although the research involved mice, it offers important insights for future studies that could lead to new approaches in diagnosis and treatment of heart patients, said Marjorie Maillet, Ph.D., the study's first author.

"We found that when you eliminate calcineurin, a pool of genes that regulates calcium in the heart went awry. This leads to defects in the growth and proliferation of heart cells, heart disease, arrhythmia, loss of contractility and heart failure and disease," said Dr. Maillet.

Calcium is also important to cardiac growth and the contraction of heart muscle. Previous studies have linked abnormalities in calcium handling to cardiac disease, especially in adults. In mice genetically bred for calcineurin deficiency, the researchers saw that this deficiency causes a dramatic reduction in the expression of genes that coordinately regulate calcium-handling and contraction.

The scientists also report a newly identified "feed-forward" mechanism, in which the direct activation of calcineurin by calcium augments the expression of genes that regulate calcium-handling proteins in the heart.

Dr. Maillet works in the laboratory of the study's senior investigator, Jeffery Molkentin, Ph.D., a researcher in the division of Molecular Cardiovascular Biology at Cincinnati Children's and a Howard Hughes Medical Institute Investigator. Dr. Molkentin's laboratory and division are also part of the Cincinnati Children's Heart Institute.

Also collaborating on the study were researchers from the University Paris-Sud, Chtenay-Malabry, France and the department of Molecular and Cellular Physiology at the University of Cincinnati College of Medicine.


'/>"/>

Contact: Nick Miller
nicholas.miller@cchmc.org
513-803-6035
Cincinnati Children's Hospital Medical Center
Source:Eurekalert

Related biology news :

1. Sanford-Burnham scientists identify natural compound that inhibits cancer cell migration
2. Scientists discover molecular pathway for organ tissue regeneration and repair
3. Scientists synthesize unique family of anti-cancer compounds
4. ASU scientists develop universal DNA reader to advance faster, cheaper sequencing efforts
5. USDA scientists sequence genome of grass that can be a biofuel model crop
6. Prevention is key research goal for premature babies, scientists say
7. Caltech neuroscientists discover brain area responsible for fear of losing money
8. Virus-free technique enables Stanford scientists to easily make stem cells pluripotent
9. Scientists identify first genetic variant linked to biological aging in humans
10. ARS scientists turn to a wild oat to combat crown rust
11. Scientists find quantum mechanics at work in photosynthesis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/17/2016)... 2016 ABI Research, the leader in ... biometrics market will reach more than $30 billion ... 2015. Consumer electronics, particularly smartphones, continue to boost ... to reach two billion shipments by 2021 at ... , Research Analyst at ABI Research. "Surveillance is ...
(Date:3/11/2016)... http://www.apimages.com ) - --> http://www.apimages.com ... at AP Images ( http://www.apimages.com ) - Germany ... produce the new refugee identity cards. DERMALOG will be unveiling this ... Hanover next week.   --> ... to produce the new refugee identity cards. DERMALOG will be unveiling ...
(Date:3/9/2016)... 2016 Nigeria . ... than 23,000 public service employees either did not exist ... salary unlawfully.    --> Nigeria ... more than 23,000 public service employees either did not ... their salary unlawfully.    --> DERMALOG, the ...
Breaking Biology News(10 mins):
(Date:5/24/2016)... (PRWEB) , ... May 24, 2016 , ... ... a newly re-branded identity. The new Media Cybernetics corporate branding reflects a results-driven ... of imaging and image analysis. The re-branding components include a crisp, refreshed logo ...
(Date:5/23/2016)... ... 2016 , ... PrecisionAg® Media has released its latest White ... paper outlines the key trends that are creating both opportunities and challenges for ... of highs and lows as the precision agriculture market has grown and matured ...
(Date:5/23/2016)... -- Oxitec CEO Hadyn Parry will ... ET before the United States House Committee on Science, Space ... in controlling the spread of the Aedes aegypti ...      (Logo: http://photos.prnewswire.com/prnh/20150630/227348 ) Oxitec has ... Trials in Brazil , Panama ...
(Date:5/23/2016)... North Carolina (PRWEB) , ... May 23, 2016 ... ... automation and building management solutions and services based in Aurora, Ohio, has broken ... of established business in the Research Triangle Park area, this new location solidifies ...
Breaking Biology Technology: