Navigation Links
Scientists identify cell changes leading to impaired 'artificial kidney' function
Date:10/27/2008

Molecular targets identified by a Spanish research team may hold the key to freedom for some sufferers of kidney disease. A new study published in Disease Models & Mechanisms (DMM), dmm.biologists.org, reveals the cellular signals which cause one treatment for kidney failure to lose its usefulness over time.

One of the most devastating aspects of kidney failure is the strict, time-consuming treatment regimen. Normally, healthy kidneys take on the role of filtering and cleaning the blood. Therefore patients with diseased kidneys traditionally need to attend a dialysis clinic to have their blood cleaned through a special filter. This treatment requires three regular clinic visits per week, with each session lasting three to five hours.

An alternative to this treatment involves creation of an "artificial kidney" in a process known as peritoneal dialysis (PD). Fluid is inserted into the abdominal cavity, and the blood vessel-rich cavity lining, the peritoneum, acts as a filter for the blood. Exchanges of dialysis fluid can take place at home, thus freeing patients of a rigid schedule of clinic visits.

However, the filtration ability of the peritoneum can lose efficiency over time, requiring patients to discontinue PD. In order to understand this change in the peritoneum, scientists Raffaele Strippoli, Miguel del Pozo and colleagues examined the dialysis fluid from PD patients, and identified molecular signals that cause abnormal changes in the peritoneum. They also found that pharmacologically disrupting these signals causes these abnormal cells to revert back to their original state, as they normally existed in the abdominal cavity lining.

These findings support further research on maintaining the effectiveness of PD, and indicate that perhaps even former PD patients could once again have an option to use PD rather than traditional hemodialysis. Additionally, the cellular changes
'/>"/>

Contact: Donna Perry
donna@biologists.com
44-122-343-3319
The Company of Biologists
Source:Eurekalert

Page: 1 2

Related biology news :

1. Scientists achieve first tracking of salmon from headwaters in Rockies through Pacific to Alaska
2. NIAID scientists to speak on range of infectious disease topics at major scientific meeting
3. British scientists go cloud-hopping in the Pacific to improve climate predictions
4. Scientists map soils on an extinct American volcano
5. Scientists call for protected swimways for the endangered leatherback sea turtle
6. Scientists from Granada find a potential treatment to prevent diabetes and obesity
7. Scientists discover bacteria that can cause bone infections
8. Scientists propose the creation of a new type of seed bank
9. EMBO honors 59 leading life scientists
10. Caltech scientists engineer supersensitive receptor, gain better understanding of dopamine system
11. Extreme nature helps scientists design nano materials
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/19/2014)... made to decrease China,s increasing caesarean section rate, suggests ... BJOG: An International Journal of Obstetrics and Gynaecology (BJOG) ... delivery rates in the world. Of 16 million babies ... the exact rate is not known, the current Chinese ... caesarean rates ranging from 36% to 58%. However, before ...
(Date:8/19/2014)... week,s Eos: Long-Term Ecological Research and Network-Level Science, , ... a wide range of ecosystems was responding to global ... particularly powerful if it coupled multiple decades of information ... experiments and models from dozens of different ecosystem types. ... the Long-Term Ecological Research (LTER) Network, which will soon ...
(Date:8/19/2014)... devised a new implantable tissue scaffold coated with bone ... weeks. When applied to bone injuries or defects, this ... bone that looks and behaves just like the original ... a dramatic improvement over the current standard for treating ... of the patient,s body a painful process that ...
Breaking Biology News(10 mins):Is China's 50 percent cesarean section delivery rate too high? 2Is China's 50 percent cesarean section delivery rate too high? 3This week from AGU: Long-term ecological research, predicting cholera outbreaks 2Engineering new bone growth 2Engineering new bone growth 3
... 1, 2011 A pair of University of Houston ... develop new methods for treating the most severe form ... recently awarded by the Cancer Prevention and Research Institute ... Jan-ke Gustafsson, Robert A. Welch Professor in UH,s biology ...
... CORVALLIS, Ore. Engineers at Oregon State University ... adhesives in the production of low-temperature, microchannel heat ... promising technology much less expensive for many commercial ... needed, researchers say, in next-generation computers, lasers, consumer ...
... April 1, 2011 Avila Therapeutics, Inc., a biotechnology ... publication of a scientific review article in ... Covalent Drugs" ( www.nature.com/reviews/drugdisc , Vol. 10, April 2011, ... for covalent drugs and how structural bioinformatics coupled with ...
Cached Biology News:Jan-Åke Gustafsson leads team with $5.2M for prostate cancer research 2Advance in microchannel manufacturing opens new industry applications 2New opportunities for covalent drugs published by Avila scientists 2
(Date:8/20/2014)... measuring vibrational motion of a single molecule with a ... a single molecule differs from the behaviour of larger ... the University of California, Irvine, where post-doctoral researcher Eero ... visiting fellow under professor Vartkess A. Apkarian, whose team ... by Professor Eric O. Potma. The results of the ...
(Date:8/20/2014)... -- PAREXEL International Corporation (NASDAQ: PRXL ) announced ... Healthcare Conference in New York.  Ingo Bank , ... making a presentation on PAREXEL and discussing business developments ... A live webcast of the discussion will ... at www.PAREXEL.com in the Upcoming Events portion ...
(Date:8/20/2014)... nerves in your ear could improve the health of ... the University of Leeds used a standard TENS machine ... electrical pulses to the tragus, the small raised flap ... of the ear canal. , The stimulation changed the ... reducing the nervous signals that can drive failing hearts ...
(Date:8/19/2014)... Shimadzu Scientific Instruments has introduced ... Nexera-i, adding to the company’s extensive line-up of ... intuitive operating environment, and full automation, the i-Series ... for conventional to ultra-high-speed analysis. , ... design so users can begin building the lab ...
Breaking Biology Technology:Seeing a molecule breathe 2PAREXEL International To Present At Baird Healthcare Conference 2'Tickling' your ear could be good for your heart 2Shimadzu’s New i-Series Integrated Liquid Chromatography Systems Provide Laboratories Wider Range of Analytical Capabilities 2Shimadzu’s New i-Series Integrated Liquid Chromatography Systems Provide Laboratories Wider Range of Analytical Capabilities 3
... -- China Medical,Technologies, Inc. (the ,Company,) (Nasdaq: ... company that develops, manufactures and markets advanced ... focused ultrasound,tumor therapy system, today announced that ... ,Acquisition,) of the entire interest in,Beijing Bio-Ekon ...
... Broadband Wireless Technology, Will, Provide Free Internet Access to Kindergartens, ... ... PETACH TIKVA, Israel, January 8 012,Smile.Communications (NASDAQ: SMLC ... announced that it has joined,with Israel,s Ministry of Communications, Intel ...
... team of U.S., Israeli and German scientists used computational ... role in human cell division and to identify more ... pattern of activation in cancer cells., Malignant cells have ... in cell cycle gene activation in normal and malignant ...
Cached Biology Technology:China Medical Technologies Completes Acquisition of BBE 2Israel's Ministry of Communications, 012 Smile.Communications, Intel and Alvarion Join in Launching WiMAX Initiative for Sderot, a City in the Western Negev 2Israel's Ministry of Communications, 012 Smile.Communications, Intel and Alvarion Join in Launching WiMAX Initiative for Sderot, a City in the Western Negev 3Israel's Ministry of Communications, 012 Smile.Communications, Intel and Alvarion Join in Launching WiMAX Initiative for Sderot, a City in the Western Negev 4Israel's Ministry of Communications, 012 Smile.Communications, Intel and Alvarion Join in Launching WiMAX Initiative for Sderot, a City in the Western Negev 5International team identifies 480 genes that control human cell division 2International team identifies 480 genes that control human cell division 3
High-throughput DNA preparation and end sequencing of BAC libraries. 3730xl DNA sequencers. LIMS tracking utilizing Geospiza's Finch system. Full-length BAC sequencing also available. Our expertise h...
... is the experimental process of determining the ... automated DNA Sequencing is based on Sangers ... which allows cycle sequencing reactions. The resulting ... a capillary instrument controlled by a computer ...
... 192 ) The antibody is preadsorbed to remove ... antibody buffered aqueous glycerol solution A ... Mg 2+ and Ca 2+ ), pH ... BSA (IgG, protease free) and 0.05% sodium azide ...
... The Bio-Plex maintenance, calibration, ... a custom 96-well plate used ... and calibration procedures using the ... MCV plate is for use ...
Biology Products: