Navigation Links
Scientists identify a surprising new source of cancer stem cells
Date:4/11/2011

ing cancer stem cells, Weinberg cautions that the plasticity seen in these basal cells suggests a more complicated scenario than previously thought.

"Future drug therapies that are targeted against cancer will need to eliminate the cancer stem cells and, in addition, get rid of the non-stem cells in tumors both populations must be removed," says Weinberg, who is also a professor of biology at MIT. "Knocking out one or the other is unlikely to suffice to generate a durable clinical response."

Chaffer is now focusing on what actually prompts these flexible cells to de-differentiate, and in the case of cancer cells, how to stop the cells from converting into cancer stem cells.

"This plasticity can occur naturally, and it seems that the trigger may be a physiological mechanism for restoring a pool of stem cells," says Chaffer. "We believe that certain cells are more susceptible to such a trigger and therefore to conversion from a differentiated to a stem-like state, and that this process occurs more frequently in cancerous cells."

In the case of normal epithelial cells, the observed behavior may also allow patient specific adult stem cells to be derived without genetic manipulation, holding promise for degenerative disease therapy.


'/>"/>

Contact: Nicole Giese
giese@wi.mit.edu
617-258-6851
Whitehead Institute for Biomedical Research
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Scripps Research scientists uncover new DNA role in modifying gene function
2. Outsmarting cancer cells: SLU scientists learn how they spread
3. Scripps Research scientists find dual switch regulates fat formation
4. Scientists make bamboo tools to test theory explaining East Asias Stone Age tool scarcity
5. Scientists exploit ash tree pests chemical communication
6. S.L.E. Lupus Foundation announces new grants to further NYC scientists leadership in lupus research
7. Scientists develop new technology for stroke rehabilitation
8. Common chaperone protein found to work in surprising way, say Scripps Research scientists
9. New opportunities for covalent drugs published by Avila scientists
10. NOAA scientists find killer whales in Antarctic waters prefer weddell seals over other prey
11. Scientists Without Borders awards $10,000 to solvers of maternal health and nutrition challenge
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... , Dec. 15, 2014 Research and Markets ... addition of the "Samsung Galaxy S5 - ... report to their offering. ... totally different sensing technology than the iPhone 5S, ... sensor in its product. The Galaxy ...
(Date:12/17/2014)... YORK , Dec. 15, 2014  HITLAB ... Good Clinical Practices (GCP) audit to confirm its ... (FDA) regulations. This accomplishment enables HITLAB to conduct ... utilizing the highest principles for patient safety and ... improve global healthcare access, quality, and delivery with ...
(Date:12/17/2014)... , Dec. 16, 2014 Research and ... the addition of the "Global Chemical Sensor ... http://photos.prnewswire.com/prnh/20130307/600769 ... the increasing demand for medical sensors in biomedical ... data for quick and correct diagnosis during surgical ...
Breaking Biology News(10 mins):Samsung Galaxy S5 - Home Button Synaptics Fingerprint Sensor Technology Analysis 2HITLAB Completes GCP Audit for FDA Smart Device & App Compliance 2Global Chemical Sensor Market 2015-2019: Key Vendors are Abbott Laboratories, Bayer, Hoffmann La-Roche, Johnson & Johnson, NGK Spark Plugs and Robert Bosch 2
... Change: Required Reductions of Carbon Emissions to Protect Young ... colleagues, and announces call for papers on responses to ... impacts of global warming using ongoing observations and paleoclimate ... representations of the global carbon cycle and temperature to ...
... EVENT: The second annual Epigenetic Control and ... and chromatin remodeling contribute to various processes that lead ... Friday, Dec. 12-13, at the At the Beckman Center ... Irvine, Calif. INFORMATION: Media planning to ...
... to sustaining life on Earth, is proving deadly for young peregrine ... in Oecologia has found that an increase in the ... posing a threat not seen in this species since before pesticides ... , The study is among the first to directly link rainfall ...
Cached Biology News:Assessing dangerous climate change and call for climate change response papers 2Top scientists to present at Epigenetic Control and Cellular Plasticity symposium 2Rainfall to blame for decline in Arctic peregrines 2
(Date:12/19/2014)... NEW YORK , Dec. 18, 2014 ... novel therapies for the treatment of chronic pain, announced ... held today. "This was a transformational year ... a promising future for our company," said Sergio ... past year, we have executed on key financial, human ...
(Date:12/17/2014)... December 17, 2014 Ipsen Biopharmaceuticals, ... IPN; ADR: IPSEY), today announced that ... as Somatuline®) was approved by the U.S. Food ... gastroenteropancreatic neuroendocrine tumors (GEP-NETs) in adult patients with ... metastatic disease to improve progression-free survival (PFS). , ...
(Date:12/17/2014)... Audacity, a leading California-based health and ... the Huntsworth Health Group, is proud to announce the ... her role, Gonzales will serve as Senior Vice President ... to welcome a talent of Jamie’s caliber to the ... “She is a proven healthcare innovation leader and brand ...
(Date:12/17/2014)... Mass. , Dec. 17, 2014   Synageva ... biopharmaceutical company developing therapeutic products for rare disorders, announced ... Conference being held in San Francisco, CA. ... President and Chief Executive Officer, will present on Monday, ... EST).  The presentation will be webcast live and may ...
Breaking Biology Technology:Relmada Therapeutics Announces Results of Annual Shareholders Meeting 2Ipsen Announces the FDA Approval of Somatuline® Depot® (lanreotide) Injection for the Treatment of Gastroenteropancreatic Neuroendocrine Tumors 2Ipsen Announces the FDA Approval of Somatuline® Depot® (lanreotide) Injection for the Treatment of Gastroenteropancreatic Neuroendocrine Tumors 3Ipsen Announces the FDA Approval of Somatuline® Depot® (lanreotide) Injection for the Treatment of Gastroenteropancreatic Neuroendocrine Tumors 4Ipsen Announces the FDA Approval of Somatuline® Depot® (lanreotide) Injection for the Treatment of Gastroenteropancreatic Neuroendocrine Tumors 5Ipsen Announces the FDA Approval of Somatuline® Depot® (lanreotide) Injection for the Treatment of Gastroenteropancreatic Neuroendocrine Tumors 6Ipsen Announces the FDA Approval of Somatuline® Depot® (lanreotide) Injection for the Treatment of Gastroenteropancreatic Neuroendocrine Tumors 7Ipsen Announces the FDA Approval of Somatuline® Depot® (lanreotide) Injection for the Treatment of Gastroenteropancreatic Neuroendocrine Tumors 8Audacity Welcomes Healthcare Communications Expert Jamie Gonzales as Senior Vice President of Client Services 2
... high-tech networking event starting in Appleton, Wisconsin. The ... investors and others who live in the Fox ... Tobey Andropolis and Bob Pankratz insist that this ... enterprise. Instead, the Hive is devoted to helping ...
... 2004 in Lille, France. This four-year-old conference draws ... transformative power of technology. As the lead speaker on ... and Social Conditions, I was eager, frankly, to dispense ... to hear from and debate my fellow panelists. , ...
... scientists have research on the brain. In the past few ... effort into projects that can combat neural disorders and help ... area of human testing and getting closer to market, their ... Implants encourage mind over movement ,One major effort at ...
Cached Biology Technology:A new high-tech networking event buzzes in Appleton 2A new high-tech networking event buzzes in Appleton 3Achieving digital solidarity 2Achieving digital solidarity 3Achieving digital solidarity 4Mental research at UW-Madison could correct disabilities 2Mental research at UW-Madison could correct disabilities 3
[5,6,8,9,12,14,15(n)-3H]Prostaglandin D2, 925 kBq, 25 uCi. Methanol:water:acetonitrile (3:2:1) solution.> 3.0 TBq/mmol, > 80 Ci/mmol.3.7 MBq/ml, 100 uCi/ml. Category: Radiochemicals &Radiation Safety...
...
One-step, microplate or cuvet, turbidometric, linear detection range 0.096 mg/dL to 11.5 mg/dL. Procedure: 5 min....
One-step, microplate or cuvet, colorimetric, detection range 0.1 mg/dL to 3 mg/dL. Procedure: 10 min....
Biology Products: