Navigation Links
Scientists identify a molecule that coordinates the movement of cells
Date:10/2/2008

esion dynamics within the cell, ACF7 becomes an orchestrator of directed cellular movement."

In particular, Wu and Fuchs, who is also a Howard Hughes Medical Institute investigator and Rebecca C. Lancefield Professor at Rockefeller, found that without ACF7, microtubules were no longer guided toward the focal adhesions in a directed manner. They also noticed that cellular movement slowed, suggesting that the sticky adhesive sites were no longer assembling and disassembling efficiently.

To figure out why, Fuchs and Wu studied how quickly wounds heal in mice. "During injury, stem cells proliferate and migrate to the affected site and replenish lost cells," explains Wu. "We saw that the cells without ACF7 proliferated normally, but they moved very, very slowly compared to normal skin cells. So the problem wasn't with abnormal proliferation but with cell migration." When the researchers mutated ACF7 so it couldn't release stored energy in cells, ACF7 linked f-actin and microtubules but the cells were also sluggish in their movement.

In previous work, the Fuchs team had already showed that ACF7 appeared side by side with focal adhesion molecules, but they never knew, until now, that ACF7 guides microtubules along actin cables to these sites. "Now, we have a better idea of why it's important for ACF7 to be there," says Fuchs. "In order to make the adhesive sites dynamically stick and unstick, assembly and disassembly factors need to be recruited there. The intracellular roadway governed by ACF7 makes that possible."

In the future, this information could be relevant in developing cancer therapeutics. "A major goal in the clinical arena is to halt cancer cells from migrating, a process important in metastasis," says Fuchs. By suppressing ACF7's function in cancer cells, it might be possible to slow metastasis.


'/>"/>

Contact: Thania Benios
tbenios@rockefeller.edu
212-327-7146
Rockefeller University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Thinking it through: Scientists call for policy to guide biofuels industry toward sustainability
2. Earth scientists keep an eye on Texas
3. MU scientists see how HIV matures into an infection
4. Scientists discover why a mothers high-fat diet contributes to obesity in her children
5. Scientists identify gene that may contribute to improved rice yield
6. MU scientists go green with gold, distribute environmentally friendly nanoparticles
7. Argonne scientists peer into heart of compound that may detect chemical, biological weapons
8. Scientists identify novel inhibitor of human microRNA
9. Jefferson scientists deliver toxic genes to effectively kill pancreatic cancer cells
10. ESA trains next generation of atmospheric scientists
11. Scientists find redesigned hammer that forged evolution of pregnancy in mammals
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/15/2014)... Research and Markets ( http://www.researchandmarkets.com/research/87pph8/global_facial ... "Global Facial Recognition Market 2015-2019" report to ... Facial recognition is a technology ... system measures the overall facial feature of a ... the distance between eyes. Facial recognition is used ...
(Date:12/11/2014)... 2014  Data Sciences International (DSI), the global ... new series of digital telemetry implants to meet ... series, part of the PhysioTel™ Digital platform, was ... physiologic data when incorporating functional endpoints into repeat-dose ... toxicology studies has evolved from short ECG strips ...
(Date:12/10/2014)... DIEGO , Dec. 9, 2014 CIE ... collaboration catalyst that provides the connective tissue that enhances ... enabling them to easily share client-level information; earned a ... to expand to organizations serving seniors aging in community ... Diego" partner on December 11 th 4-6p. ...
Breaking Biology News(10 mins):Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 3New telemetry implants expected to change how large animal toxicology studies are conducted 2Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 2Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 3Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 4
... In recent years, the 1.5 kilos of bacteria that live ... crucial importance for our healthy functioning. Beyond their more obvious ... the development of the immune system and the neuronal system, ... European researchers on the gut microbiome will share their recent ...
... 13, 2014Food spoiling and poisoning caused by microbial contamination ... broad scope of antimicrobial approaches to kill or prevent ... a variety of natural and artificial preservative strategies, are ... Biotechnology , a peer-reviewed journal from Mary Ann Liebert, ...
... in climate change science have shifted over the past ... while new research challenges rose to the fore. Scientists ... and international policymakers will examine the state-of-the-science in "Research ... We Going?" on Feb. 14 at the American Association ...
Cached Biology News:Hot issues in climate change research to be debated at AAAS Annual Meeting 2
(Date:12/19/2014)... The empty capsules market is experiencing growth ... technological innovations in the empty capsules market. The ... growth of the empty capsules market. , Get ... of Report , The report will enrich both ... to gauge the pulse of the market which ...
(Date:12/19/2014)... -- Relmada Therapeutics, Inc. (OTCQB: RLMD), a clinical-stage company ... announced the results of its annual general meeting of ... year in Relmada,s history and it set the stage ... Sergio Traversa , chief executive officer of Relmada. "Over ... human resource and clinical development objectives that position Relmada ...
(Date:12/17/2014)... (PRWEB) December 17, 2014 Ipsen ... IPN; ADR: IPSEY), today announced that ... to as Somatuline®) was approved by the U.S. ... of gastroenteropancreatic neuroendocrine tumors (GEP-NETs) in adult patients ... or metastatic disease to improve progression-free survival (PFS). ...
(Date:12/17/2014)... (PRWEB) December 17, 2014 Audacity, a ... agency and member of the Huntsworth Health Group, is ... its executive team. In her role, Gonzales will serve ... “We are incredibly honored to welcome a talent of ... and CEO, Gaëtan Fraikin. “She is a proven healthcare ...
Breaking Biology Technology:Empty Capsules Market Hit to Reach $1,820 Million by 2019 - New Research Report by MarketsandMarkets 2Empty Capsules Market Hit to Reach $1,820 Million by 2019 - New Research Report by MarketsandMarkets 3Empty Capsules Market Hit to Reach $1,820 Million by 2019 - New Research Report by MarketsandMarkets 4Relmada Therapeutics Announces Results of Annual Shareholders Meeting 2Ipsen Announces the FDA Approval of Somatuline® Depot® (lanreotide) Injection for the Treatment of Gastroenteropancreatic Neuroendocrine Tumors 2Ipsen Announces the FDA Approval of Somatuline® Depot® (lanreotide) Injection for the Treatment of Gastroenteropancreatic Neuroendocrine Tumors 3Ipsen Announces the FDA Approval of Somatuline® Depot® (lanreotide) Injection for the Treatment of Gastroenteropancreatic Neuroendocrine Tumors 4Ipsen Announces the FDA Approval of Somatuline® Depot® (lanreotide) Injection for the Treatment of Gastroenteropancreatic Neuroendocrine Tumors 5Ipsen Announces the FDA Approval of Somatuline® Depot® (lanreotide) Injection for the Treatment of Gastroenteropancreatic Neuroendocrine Tumors 6Ipsen Announces the FDA Approval of Somatuline® Depot® (lanreotide) Injection for the Treatment of Gastroenteropancreatic Neuroendocrine Tumors 7Ipsen Announces the FDA Approval of Somatuline® Depot® (lanreotide) Injection for the Treatment of Gastroenteropancreatic Neuroendocrine Tumors 8Audacity Welcomes Healthcare Communications Expert Jamie Gonzales as Senior Vice President of Client Services 2
... has received a $500,000 federal research grant, the company ... small-business innovation research grant from the National Science ... The funding complements the $100,000 phase I grant the ... ,According to Sal Braico, ConjuGons chief operating officer, the ...
... a rainbow arches from its HQ all the way to prison. ... sheds its old image of ENWRONG to PRISMA. After paying $665 ... identity of PRISMA while some of its executives walk to prison. ... a staff of 5000 in 25 different business units, a big ...
... use Wisconsin Impact Fund to distribute loans , , ... Technology Campus Web site . MADISON, Wis. - The Wisconsin ... , the developer of a commercial campus on Madison's south side, ... , ,The Federal New Markets Tax Credit Program offers ...
Cached Biology Technology:ConjuGon receives $500,000 to battle bacteria 2Why is Enron now called Prisma? 2Why is Enron now called Prisma? 3Novation Technology Campus gets $3.5 million boost 2
Goat polyclonal to Haptoglobin ( Abpromise for all tested applications). Antigen: Affinity purified human haptoglobin. Entrez GeneID: 3240 Swiss Protein ID: P00738...
... Pyruvate Kinase. This product is ... from other mammalian species but has ... Gives a single precipitin line against ... been shown to react with all ...
Recorder, 6", 7 Day, 1 Pen, 0 to 100°C, 220V, 50/60 Hz, for 4520, Customer Installed...
... Shimadzu Phoretix 2D, Expression and Evolution supports ... comparative gel analysis studies in determining differential ... on component Oracle data base ... 2 client software). Supports advanced ...
Biology Products: