Navigation Links
Scientists identify FLT3 gene as a valid therapeutic target in acute myeloid leukemia
Date:4/15/2012

is also Co-Director of the Institute for Genomics and Multiscale Biology at Mount Sinai. "Furthermore, if we can find out when the drug resistant mutations occur exactly, clinicians may be able to prescribe another drug more quickly."

In this era of personalized medicine, many drugs have been developed to target the mutations in genes that cause cancer - in an effort to attack the cancer with minimal side effects. Oftentimes, patients develop resistance to drugs and new therapeutic strategies must be applied, so physicians use a second line drug, or combination of drugs, in an effort to target the new gene mutations that develop. Knowing exactly when this mutation and subsequent resistance occurs may be very helpful in identifying when new therapies may be prescribed.

In this study, researchers worked with eight leukemia patients who had participated in a clinical trial involving a compound known as AC220, the first clinically-active FLT3 inhibitor. All eight patients relapsed after first achieving deep remissions with AC220. The relapse indicated that patients had developed a resistance to the drug.

AML is characterized by the rapid growth of abnormal white blood cells that accumulate in the bone marrow and interfere with the production of normal blood cells. Treatment includes chemotherapy in order to eliminate leukemic cells and stem cell transplantation. However, through the identification of a valid therapeutic target (FLT3), scientists can begin to develop new and more effective therapies in the future.

"Mount Sinai is deeply committed to addressing the problem of drug resistance in all diseases including cancer and infections with viruses or bacteria," said Kasarskis. "This study certainly tries to address the issue, and will look forward to making continued progress in this area."


'/>"/>
Contact: Mount Sinai Press Office
newsmedia@mssm.edu
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine
Source:Eurekalert

Page: 1 2

Related biology news :

1. Scientists complete first-ever emperor penguin count from space
2. Scientists count penguins from space
3. Researchers use game to change how scientists study disease outbreaks
4. Salk scientists redraw the blueprint of the bodys biological clock
5. Scientists study the catalytic reactions used by plants to split oxygen from water
6. Scripps Research Institute scientists find promising vaccine targets on hepatitis C virus
7. Dartmouth scientists track radioactive iodine from Japan nuclear reactor meltdown
8. Genetic mutation depicted in van Goghs sunflower paintings revealed by scientists
9. UGA scientists reveal genetic mutation depicted in van Goghs sunflower paintings
10. Scientists win $2 million to study new pathway in development and maintenance of lymphoma
11. WileyChina.com - Now Featuring Bespoke Pages for China’s Life Scientists
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/7/2015)... , May 7, 2015 ... fingerprint sensors, FPC1022 and FPC1035, FPC,s smallest touch ... FPC1035 are mainly considered for integration on the ... gives smartphone OEMs increased possibilities to integrate touch ... decreased size also improves possibilities for module manufacturers ...
(Date:4/27/2015)... ATLANTA , April 27, 2015  For more ... and trade show has been the premier worldwide event ... Systems 2015 is a must-attend event for any local, ... insight into the emerging commercial markets and current applications ... and innovations of this projected $48 billion industry, and ...
(Date:4/21/2015)... April 21, 2015 High ... policies are boosting access control systems market in ... to a recently published report by TechSci Research " ... the access control systems market in Saudi ... by 2020.The access control systems market in the Kingdom ...
Breaking Biology News(10 mins):FPC Introduces its Smallest Touch Fingerprint Sensors to Date 2UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 2UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 3UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 4UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 5Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 2Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 3
... CAMBRIDGE, Mass. (April 2, 2009) Whitehead Institute researchers have ... have further clarified the role prions play in the inheritance ... in the field is are the prions functional are ... disease, as in "mad cow," disease in mammals," says Randal ...
... Since the days of Charles Darwin, researchers are interested ... the development of animal and plant species during their ... has already come quite a long way. But there ... animal groups that made their apparation very early in ...
... directly affect human survival and food security, especially as ... groups of social insects to cultivate crops, have harvested ... 50 million years. New results from the Smithsonian show ... combat fungi coming into the nest inside leaves, thus ...
Cached Biology News:Redefining what it means to be a prion 2Redefining what it means to be a prion 3Early family ties: No sponge in the human family tree 2Early family ties: No sponge in the human family tree 3Food security for leaf-cutting ants: Workers and their fungus garden reject endophyte invaders 2
(Date:6/1/2015)... 2015 Research and ... addition of the "Oxidative Stress Assay ... Type (Indirect, Enzyme-based, Reactive Oxygen Species (ROS)-based), ... - Global Forecast to 2020" report ... http://photos.prnewswire.com/prnh/20130307/600769) , The global oxidative ...
(Date:6/1/2015)... , June 1, 2015 GenomeDx ... genomic analysis platform, successfully classified various subtypes ... expression of certain biomarkers, including one type ... this unique genomic signature has potential as ... neoadjuvant chemotherapy in patients with muscle-invasive bladder ...
(Date:6/1/2015)... EAST HANOVER, N.J. , June 1, 2015 ... Phase II clinical study of CTL019, an investigational ... indicate its potential in the treatment of specific ... ongoing study conducted by the University of Pennsylvania,s ... relapsed or refractory (r/r) diffuse large B-cell lymphoma ...
(Date:6/1/2015)... Morton Grove, IL (PRWEB) June 01, 2015 ... leader in developing and manufacturing of chiral stationary ... Expanding the options for its current and presenting ... Separation Service to its portfolio. This valuable addition ... a fast and effective advantage that can tackle ...
Breaking Biology Technology:Oxidative Stress Assay Market 2015 - Global Forecast to 2020 2GenomeDx's Decipher Platform Validates Genomic Signature that may Predict Resistance to Chemotherapy in Bladder Cancer Patients in Study Presented at ASCO 2015 Annual Meeting 2GenomeDx's Decipher Platform Validates Genomic Signature that may Predict Resistance to Chemotherapy in Bladder Cancer Patients in Study Presented at ASCO 2015 Annual Meeting 3GenomeDx's Decipher Platform Validates Genomic Signature that may Predict Resistance to Chemotherapy in Bladder Cancer Patients in Study Presented at ASCO 2015 Annual Meeting 4Novartis highlights CTL019 data showing its potential in the treatment of specific types of hard-to-treat non-Hodgkin lymphoma 2Novartis highlights CTL019 data showing its potential in the treatment of specific types of hard-to-treat non-Hodgkin lymphoma 3Novartis highlights CTL019 data showing its potential in the treatment of specific types of hard-to-treat non-Hodgkin lymphoma 4Novartis highlights CTL019 data showing its potential in the treatment of specific types of hard-to-treat non-Hodgkin lymphoma 5Novartis highlights CTL019 data showing its potential in the treatment of specific types of hard-to-treat non-Hodgkin lymphoma 6Regis Technologies Offers Chiral Chromatography Service 2Regis Technologies Offers Chiral Chromatography Service 3
... , ... throughout all industries, which were once inspected with vision and or touch-probe, will now ... critical to batch production with tight tolerance levels which can now be easily monitored ... ...
... ... recruitment strategies. CenterWatch discusses tips to leverage online resources to enhance patient recruitment rates at ... ... study volunteers, the Internet is rated as one of the top ways patients learn about ...
... Md. , Jan. 12 Novavax, Inc. (Nasdaq: ... a pre-clinical safety and efficacy study of its RSV vaccine ... to support an Investigational New Drug (IND) application to advance ... candidate into clinical development.  This vaccine candidate is composed of ...
Cached Biology Technology:Nanometer Online Inspection With Nanovea 3D Non-Contact Profilometer 2CenterWatch to Address Importance of Web Use to Boost Patient Recruitment Rates 2CenterWatch to Address Importance of Web Use to Boost Patient Recruitment Rates 3NOVAVAX Announces Positive Preclinical Results for its Respiratory Syncytial Virus (RSV) Vaccine Candidate 2NOVAVAX Announces Positive Preclinical Results for its Respiratory Syncytial Virus (RSV) Vaccine Candidate 3NOVAVAX Announces Positive Preclinical Results for its Respiratory Syncytial Virus (RSV) Vaccine Candidate 4NOVAVAX Announces Positive Preclinical Results for its Respiratory Syncytial Virus (RSV) Vaccine Candidate 5
...
...
... Exiqon's miRCURY LNA technology enables sensitive ... Northern blotting. miRCURY LNA Detection probes have ... specific and sensitive detection of miRNAs. Due ... miRCURY LNA probes less than 1/10 the ...
... Roches RTS AviTag E. coli Biotinylation Kit, Linear ... 100 E. coli expression kits. (Cat. No. 3 ... reagents to rapidly generate linear expression constructs by ... based on a combination of T7 RNA polymerase ...
Biology Products: