Navigation Links
Scientists 'herd' cells in new approach to tissue engineering
Date:3/11/2014

Berkeley -- Sometimes it only takes a quick jolt of electricity to get a swarm of cells moving in the right direction.

Researchers at the University of California, Berkeley, found that an electrical current can be used to orchestrate the flow of a group of cells, an achievement that could establish the basis for more controlled forms of tissue engineering and for potential applications such as "smart bandages" that use electrical stimulation to help heal wounds.

In the experiments, described in a study published this week in the journal Nature Materials, the researchers used single layers of epithelial cells, the type of cells that bind together to form robust sheathes in skin, kidneys, cornea and other organs. They found that by applying an electric current of about five volts per centimeter, they could encourage cells to migrate along the direct current field.

They were able to make the cells swarm left or right, to diverge or converge and to make collective U-turns. They also created elaborate shapes, such as a triceratops and the UC Berkeley Cal bear mascot, to explore how the population and configuration of cell sheets affect migration.

Directing herds vs. individuals

"This is the first data showing that direct current fields can be used to deliberately guide migration of a sheet of epithelial cells," said study lead author Daniel Cohen, who did this work as a student in the UC Berkeley-UC San Francisco Joint Graduate Program in Bioengineering. "There are many natural systems whose properties and behaviors arise from interactions across large numbers of individual parts  sand dunes, flocks of birds, schools of fish, and even the cells in our tissues. Just as a few sheepdogs exert enormous control over the herding behavior of sheep, we might be able to similarly herd biological cells for tissue engineering."

Galvanotaxis the use of electricity to direct cell movement had been previously demonstrated for individual cells, but how it influences the collective motion of cells was still unclear.

"The ability to govern the movement of a mass of cells has great utility as a scientific tool in tissue engineering," said study senior author Michel Maharbiz, UC Berkeley associate professor of electrical engineering and computer sciences. "Instead of manipulating one cell at a time, we could develop a few simple design rules that would provide a global cue to control a collection of cells."

The work was borne from a project, led by Maharbiz, to develop electronic nanomaterials for medical use that was funded by the National Science Foundation's Emerging Frontiers in Research and Innovation program. The researchers collaborated with W. James Nelson, professor of molecular and cellular physiology at Stanford University and one of the world's top experts in cell-to-cell adhesion. Cohen is now a postdoctoral research fellow in Nelson's lab.

Possible wound healing applications

With our bodies full of flowing ions and salt solutions, it is no surprise that electrical signals play a big role in our physiology, from neural transmissions to muscle stimulation.

"The electrical phenomenon we are exploring is distinct in that the current produced is providing a cue for cells to migrate," said Maharbiz.

The study authors are exploring the role of bioelectrical signals in the wound healing process, building upon the discovery in 1843 that an injury to the body creates a change in the electrical field at the wound site. By mapping the changes in the electrical field when an injury occurs and as it heals, the researchers may be able to develop technology to help speed and improve the repair process.

"These data clearly demonstrate that the kind of cellular control we would need for a smart bandage might be possible, and the next part of our work will focus on adapting this technology for use in actual injuries," said Cohen.


'/>"/>

Contact: Sarah Yang
scyang@berkeley.edu
510-643-7741
University of California - Berkeley
Source:Eurekalert  

Related biology news :

1. Geoscientists to meet in Fayetteville to discuss triggered seismicity, karst & energy resources
2. Scientists discover the specific types of macrophages that affect Crohns disease severity
3. Scientists to tackle burden of cattle disease on UK farms
4. Scientists highlight the importance of nutrients for coral reefs
5. Scientists learn how pathogens hack our immune systems to go undetected
6. NPL scientists blend synthetic air to measure climate change
7. Southern insect scientists meeting in Greenville, S.C.
8. Scientists transform skin cells into functioning liver cells
9. Scientists unlock a microbial Pompeii
10. Scientists identify long distance scanner for DNA damage
11. A*STAR scientists discover proteins role in human memory and learning functions
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists 'herd' cells in new approach to tissue engineering
(Date:3/28/2017)... , March 28, 2017 The ... Hardware (Camera, Monitors, Servers, Storage Devices), Software (Video Analytics, ... Region - Global Forecast to 2022", published by MarketsandMarkets, ... 2016 and is projected to reach USD 75.64 Billion ... and 2022. The base year considered for the study ...
(Date:3/24/2017)... 24, 2017 The Controller General of Immigration from ... Abdulla Algeen have received the prestigious international IAIR Award for the ... Continue Reading ... ... Controller Abdulla Algeen (small picture on the right) have received the IAIR ...
(Date:3/23/2017)... The report "Gesture Recognition and Touchless Sensing Market by Technology (Touch-based ... to 2022", published by MarketsandMarkets, the market is expected to be worth USD ... 2022. Continue Reading ... ... ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... and LAGUNA HILLS, Calif. , Oct. ... Cancer Research, London (ICR) and University ... SKY92, SkylineDx,s prognostic tool to risk-stratify patients with multiple myeloma ... MUK nine . The University of Leeds ... partly funded by Myeloma UK, and ICR will perform the ...
(Date:10/10/2017)... ... 2017 , ... San Diego-based team building and cooking events company, Lajollacooks4u, has ... The bold new look is part of a transformation to increase awareness, appeal to ... period. , It will also expand its service offering from its signature gourmet cooking ...
(Date:10/10/2017)... 10, 2017 International research firm Parks Associates announced ... at the TMA 2017 Annual Meeting , October 11 in ... residential home security market and how smart safety and security products impact ... Parks Associates: Smart Home ... "The residential security market has ...
(Date:10/9/2017)... DIEGO , Oct. 9, 2017  BioTech ... biological mechanism by which its ProCell stem cell ... critical limb ischemia.  The Company, demonstrated that treatment ... amount of limbs saved as compared to standard ... the molecule HGF resulted in reduction of therapeutic ...
Breaking Biology Technology: