Navigation Links
Scientists guide immune cells with light and microparticles
Date:11/16/2009

New Haven, Conn.A team led by Yale University scientists has developed a new approach to studying how immune cells chase down bacteria in our bodies. Their findings are described in the November 15 issue of Nature Methods Advanced Online Publication.

When bacteria enter our bodies they secrete molecules, leaving behind chemical trails as they move through our system. It has been known for some time that immune cells follow these trails in order to hunt the bacteria. However, studying exactly how immune cells process these chemical signals has been challenging.

Now a team of scientists led by Eric Dufresne, the John J. Lee Assistant Professor of Mechanical Engineering, and Holger Kress, a postdoctoral associate in the Yale School of Engineering & Applied Science has developed a way to create artificial chemical trails that can be shaped in three dimensions over time. By controlling the chemical trails, the team was able to control the movements of neutrophils immune cells in the blood and study how they are able to respond to these signals.

The team used sponge-like microparticles, designed by the laboratory of Tarek Fahmy, associate professor of biomedical engineering at Yale, that mimicked bacteria by slowly releasing a characteristic bacterial "scent." They then moved these microparticles using focused beams of light to control the pattern of released chemicals over space and time, stimulating the immune cells to respond. The neutrophils can be seen following the microparticles on videos produced by the researchers.

"By fusing recent advances in optical and materials science, we've developed a new approach to control chemical microenvironments with light," said Dufresne, who developed holographic optical tweezers the underlying technology used to manipulate the microparticles in the late 1990s. "Until now, people have used optical tweezers to move physical objects. We've demonstrated that they can also be used to manipulate chemical gradients."

The team used two different chemicals, one of which attracted the cells and another that repelled them, to demonstrate how they could direct the neutrophils into moving along a path, either toward or away from the microparticles. They could also examine how the cells responded when there were conflicting signals sent by several of the artificial bacteria.

Chemotaxis the migration of cells based on chemical signals in their environment plays an important role in a number of biological processes and diseases beyond the immune system. "Understanding how cells move in response to chemical stimuli can help us better understand how a single egg develops into a complex organism or how brain cells grow into a network of neurons in a growing embryo, or how cancer cells spread through the body," Kress said. "This technique could give biologists insight into the ways many different types of cells respond to environmental stimuli in a wide range of situations."


'/>"/>

Contact: Suzanne Taylor Muzzin
suzanne.taylormuzzin@yale.edu
203-432-8555
Yale University
Source:Eurekalert  

Related biology news :

1. Scientists put interactive flu tracking at publics fingertips
2. Singapore scientists join international study of 10,000 vertebrates genomes
3. Scientists are first to unlock the mystery of creating cultured pearls from the queen conch
4. UM scientists create fruit fly model to help unravel genetics of human diabetes
5. USU scientists report major advance in human antibody therapy against deadly Nipah virus
6. Scientists discover influenzas Achilles heel: Antioxidants
7. EPAs new green parking lot allows scientists to study permeable surfaces that may help the environment
8. Scientists are first to observe the global motions of an enzyme copying DNA
9. Boston University scientists first to see RNA network in live bacterial cells
10. Scientists create NICE solution to pneumonia vaccine testing problems
11. Scientists of the UGR obtain a bioinsecticide to control the Mediterranean fruit fly
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists guide immune cells with light and microparticles
(Date:4/28/2016)... and BANGALORE, India , April ... EdgeVerve Systems, a product subsidiary of Infosys (NYSE: ... today announced a global partnership that will provide ... to use mobile banking and payment services.      ... a key innovation area for financial services, but it also ...
(Date:4/26/2016)... 2016 Research and Markets has ... Market 2016-2020"  report to their offering.  , ,     ... The analysts forecast the global multimodal biometrics market ... the period 2016-2020.  Multimodal biometrics is ... as the healthcare, BFSI, transportation, automotive, and government ...
(Date:4/15/2016)... 2016 Research and Markets has ... Market 2016-2020,"  report to their offering.  , ... ,The global gait biometrics market is expected to ... period 2016-2020. Gait analysis generates multiple ... used to compute factors that are not or ...
Breaking Biology News(10 mins):
(Date:5/26/2016)... May 26, 2016 Despite the volatility ... in this space. Today,s pre-market research on ActiveWallSt.com directs the ... Inc. (NASDAQ: RDUS ), Cerus Corp. (NASDAQ: ... ), and Five Prime Therapeutics Inc. (NASDAQ: FPRX ... at: http://www.activewallst.com/ On Wednesday, ...
(Date:5/25/2016)... ... May 25, 2016 , ... Thailand’s Board of ... 2016 in San Francisco. Located at booth number 7301, representatives from the Thai ... and discuss the Thai biotechnology and life sciences sector. , Deputy Secretary ...
(Date:5/25/2016)... ... 2016 , ... WEDI, the nation’s leading authority on the use of health ... has been named by the WEDI Board of Directors as WEDI’s president and CEO. ... with more than 35 years of experience in healthcare, association management and organizational leadership, ...
(Date:5/24/2016)... ... , ... Last week, Callan Capital, an integrated wealth management firm specializing in ... San Diego Life Science event at the Estancia La Jolla Resort and Spa. , ... speakers Dr. Rich Heyman, former CEO of Aragon and Seragon, and Faheem Hasnain, former ...
Breaking Biology Technology: