Navigation Links
Scientists guide immune cells with light and microparticles
Date:11/16/2009

New Haven, Conn.A team led by Yale University scientists has developed a new approach to studying how immune cells chase down bacteria in our bodies. Their findings are described in the November 15 issue of Nature Methods Advanced Online Publication.

When bacteria enter our bodies they secrete molecules, leaving behind chemical trails as they move through our system. It has been known for some time that immune cells follow these trails in order to hunt the bacteria. However, studying exactly how immune cells process these chemical signals has been challenging.

Now a team of scientists led by Eric Dufresne, the John J. Lee Assistant Professor of Mechanical Engineering, and Holger Kress, a postdoctoral associate in the Yale School of Engineering & Applied Science has developed a way to create artificial chemical trails that can be shaped in three dimensions over time. By controlling the chemical trails, the team was able to control the movements of neutrophils immune cells in the blood and study how they are able to respond to these signals.

The team used sponge-like microparticles, designed by the laboratory of Tarek Fahmy, associate professor of biomedical engineering at Yale, that mimicked bacteria by slowly releasing a characteristic bacterial "scent." They then moved these microparticles using focused beams of light to control the pattern of released chemicals over space and time, stimulating the immune cells to respond. The neutrophils can be seen following the microparticles on videos produced by the researchers.

"By fusing recent advances in optical and materials science, we've developed a new approach to control chemical microenvironments with light," said Dufresne, who developed holographic optical tweezers the underlying technology used to manipulate the microparticles in the late 1990s. "Until now, people have used optical tweezers to move physical objects. We've demonstrated that they can also be us
'/>"/>

Contact: Suzanne Taylor Muzzin
suzanne.taylormuzzin@yale.edu
203-432-8555
Yale University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Scientists put interactive flu tracking at publics fingertips
2. Singapore scientists join international study of 10,000 vertebrates genomes
3. Scientists are first to unlock the mystery of creating cultured pearls from the queen conch
4. UM scientists create fruit fly model to help unravel genetics of human diabetes
5. USU scientists report major advance in human antibody therapy against deadly Nipah virus
6. Scientists discover influenzas Achilles heel: Antioxidants
7. EPAs new green parking lot allows scientists to study permeable surfaces that may help the environment
8. Scientists are first to observe the global motions of an enzyme copying DNA
9. Boston University scientists first to see RNA network in live bacterial cells
10. Scientists create NICE solution to pneumonia vaccine testing problems
11. Scientists of the UGR obtain a bioinsecticide to control the Mediterranean fruit fly
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists guide immune cells with light and microparticles
(Date:4/24/2014)... New Rochelle, NY, April 24, 2014D-ribose is a ... nutritional supplement, and as a starting compound for ... of Escherichia coli to increase the ... step toward achieving more efficient industrial-scale production of ... in Industrial Biotechnology , a peer-reviewed journal ...
(Date:4/24/2014)... simple and cheap way of making a high-powered lens ... microscope. , Costing less than a cent, the lenses ... countries and remote areas. , The lens fabrication technique ... National University (ANU) Research School of Engineering, who collaborated ... Medical Research to find ways to transform the lentil-sized ...
(Date:4/24/2014)... Initial treatment for a brain infection caused by fungus could ... due to study by University of Liverpool scientists. , ... often fatal but are relatively neglected in medical research. ... Africa, Australasia and South East Asia and mainly affect people ... people a year. , The University research team has tested ...
Breaking Biology News(10 mins):Droplet lens 2Treatment for deadly yeast disease reduced to 3 days 2
... Reportlinker.com announces that a new market research report is ... Forecast to 2012 - http://www.reportlinker.com/p096440/Global-Biometric-Forecast-to-2012.html ... the fastest emerging markets for the past few years ... and the advent of new technologies that offered numerous ...
... and "Invasive Alien Species in the Caribbean Basin of Concern ... will be presented at a joint meeting between the Southeastern ... Caribbean Division of the American Phytopathological Society (APS). The ... San Juan, March 19-22, 2011, as hundreds of entomologists and ...
... To the surprisingly inventive uses for banana peels ... of house plants scientists have added purification of ... which concludes that minced banana peel performs better than ... journal Industrial & Engineering Chemistry Research . ...
Cached Biology News:Reportlinker Adds Global Biometric Forecast to 2012 2CSI and alien invaders in Puerto Rico 2
(Date:1/14/2014)... BETHESDA, Md. , Jan. 14, 2014 ... two institutes from the National Institutes of Health (NIH) ... safer, more effective treatments to patients on a faster ... Advancing Translational Sciences (NCATS) and the National Eye Institute ...
(Date:1/14/2014)... 14, 2014 In recent years, growing ... methods in product development and promotion has led to ... mistrust, fueled by concerns about the insidious impact of ... of spectacular fines to the world’s biggest pharmas for ...
(Date:1/14/2014)... (PRWEB) January 14, 2014 Global ... developing innovative information technology solutions for patients, physicians, ... care stakeholders, announced today the signing of a ... Food and Drug Administration (FDA). This initiative ...
(Date:1/14/2014)... UK (PRWEB) January 13, 2014 Bob ... with more than 20 years in the industry, has ... photonics . Hainsey will serve as the society’s Science ... Dr. Hainsey join SPIE as our Technology Strategist, further ...
Breaking Biology Technology:Organovo Announces Collaboration with National Institutes of Health 2Organovo Announces Collaboration with National Institutes of Health 3The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 2The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 3Global Record Systems Announces Research Collaboration Agreement with FDA to Create a Novel “Big Data” Paradigm for Collection of Patient Safety and Outcomes Information 2Photonics R&D Leader Bob Hainsey Joins SPIE Technical Staff 2
... With the first observation of thermoelectric effects at ... transistors have a nanoscale cooling effect that reduces their ... William King and electrical and computer engineering professor Eric ... April 3 advance online edition of the journal ...
... conventional optical instruments, light cannot be focused to spot ... effects. An important approach to beat this diffraction ... an allusion to their radiofrequency counterparts. They have the ... nanometer-scale dimensions, which are orders of magnitude smaller than ...
... Diego have produced the first high resolution structure of a ... was published in a paper in this week,s early online ... of Sciences by a team of chemists headed by ... UCSD. The scientists said the ability to carry structural ...
Cached Biology Technology:Self-cooling observed in graphene electronics 2Transmission lines for nanofocusing of infrared light 2Transmission lines for nanofocusing of infrared light 3
...
RABBIT ANTI PORCINE CARBOXYPEPTIDASE B...
LabFax: Immunochemistry...
... Maker, 1. Modular system for large ... up to six lab-cast or precast ... with 18- or 24-cm Immobiline DryStrip ... gel cassettes.Innovative design simplifies loading and ...
Biology Products: