Navigation Links
Scientists grow human liver tissue to be used for transplantation
Date:1/20/2011

A new study reports on the success of growing human liver cells on resorbable scaffolds made from material similar to surgical sutures. Researchers suggest that this liver tissue could be used in place of donor organs during liver transplantation or during the bridge period until a suitable donor is available for patients with acute liver failure. Findings of this study appear in the February issue of Liver Transplantation, a journal published by Wiley-Blackwell on behalf of the American Association for the Study of Liver Diseases.

As of January 2011, more than 16,000 Americans are on the waiting list to receive a suitable liver according to data from the Organ Procurement and Transplantation Network. Liver cell (hepatocyte) transplantation offers a possible solution in overcoming the organ shortage. In addition, liver cells have excellent regenerative potential making liver cell transplantation a viable therapeutic approach for patients with metabolic defects or fulminant hepatic failure as the native liver is preserved while liver dysfunction may resolve as regeneration occurs.

Dr. Joerg-Matthias Pollok, Head of the Laboratory for Tissue Engineering and Cell Transplantation, Department of Hepatobiliary and Transplantation Surgery at the University Medical Center in Hamburg, Germany explains, "Currently isolated liver cells are used for liver cell transplantation, but these cells suffer during cell isolation and cryopreservation, which is one reason there is limited success with this type of transplant procedure." In applying their tissue engineering approach, the German researchers were able to successfully create new liver tissue providing a potential solution to the obstacles challenging liver cell transplantation.

The team isolated liver cells from 12 human liver specimens with a viability of 82%. After a two-day culture period, liver cells formed tightly packed cellular aggregates, called spheroids, and took on a liver-
'/>"/>

Contact: Dawn Peters
healthnews@wiley.com
781-388-8408
Wiley-Blackwell
Source:Eurekalert

Page: 1 2

Related biology news :

1. Scientists reveal complete structure of HIVs outer shell
2. Scientists: Big city life may alter green attitudes
3. Scientists find the master switch for key immune cells in inflammatory diseases
4. MU scientists find new farming method to reduce greenhouse gases, increase farm yields
5. 7 CAMH scientists win Young Investigator awards focused on breakthrough research
6. Inside a snowstorm: Scientists obtain close-up look at Old Man Winter
7. 6 PNNL scientists elected 2010 AAAS Fellows
8. Shellfish safer to eat thanks to breakthrough by Queens scientists
9. UCSB, Texas A&M scientists find methane gas concentrations have returned to near-normal levels
10. Princeton scientists construct synthetic proteins that sustain life
11. Oil spill symposium to convene scientists, media, policymakers and community leaders
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/25/2014)... for Medical Research have identified the functions of ... to triggering the mating process in mice. , They ... detect pheromones that indicate when a female is present. ... the female mouse is ovulating and ready to mate. ... Stowers, researchers believe mice developed this system through evolution ...
(Date:7/25/2014)... detected an unknown interaction between microorganisms and salt. When ... droplet of salt water and is left to dry, ... biosaline 3D morphologically complex formations, where they hibernate. Afterwards, ... discovery was made by chance with a home microscope, ... journal and may help to find signs of ...
(Date:7/24/2014)... Scientists at The New York Stem Cell Foundation ... creating a viable cell replacement therapy for multiple ... For the first time, NYSCF scientists generated induced ... of patients with primary progressive multiple sclerosis and ... these stem cells into becoming oligodendrocytes, the myelin-forming ...
Breaking Biology News(10 mins):It takes two to court 2It takes two to court 3Bacteria manipulate salt to build shelters to hibernate 2NYSCF scientists one step closer to cell therapy for multiple sclerosis patients 2
... Chris Field, professor of interdisciplinary environmental studies at Stanford ... (IPCC) Fifth AssessmentWorking Group II. WHAT: ... change that isfaster than at any time in the last ... on the topic. WHEN: Friday, Feb. ...
... Council (MRC) has announced 580,000 of funding to facilitate ... capacity in Africa focused on the health effects of ... identified as a major preventable cause of disease and ... The BREATHE Africa partnership (Biomass Reduction and Environmental ...
... society devoted to furthering research aimed at the understanding proteins, ... awards will be conferred at the 28th Annual Symposium of ... Plenary talks from each recipient are scheduled throughout the 3.5 ... by Rigaku Corporation, is given to an outstanding protein scientist ...
Cached Biology News:MRC funds BREATHE Africa partnership 2The Protein Society announces its 2014 award recipients 2The Protein Society announces its 2014 award recipients 3
(Date:7/25/2014)... July 25, 2014 /PRNewswire-iReach/ -- Xybion Corporation, the ... global corporations operating in highly regulated industries, announced ... annual Global User Group Conference, Xybion International Exchange, ... Philadelphia, Pennsylvania at the Sheraton Society ... This year,s conference theme ...
(Date:7/24/2014)... NY - July 24, 2014 -- Keryx Biopharmaceuticals, Inc. ... the long-term, randomized, active control Phase 3 study of ... phosphate binder, for the treatment of hyperphosphatemia in patients ... study (PhosphatE binding and iRon delivery with FErric CiTrate ... Journal of the American Society of Nephrology ( ...
(Date:7/24/2014)... July 24, 2014  Now available is a stem ... Rehealth Regenerative Therapies , located in Guadalajara, ... active people a new health option: stem cell ... age, countless patients suffer from joint and muscle injuries ... muscle tears, torn rotator cuff, tennis elbow, and knee ...
(Date:7/24/2014)... on sophisticated equipment, trained personnel, and detection dogs ... terrorist attacks. A revolutionary new electronic chip with ... job much easier. , The groundbreaking nanotechnology-inspired sensor, ... University ,s School of Chemistry and Center for ... company Tracense, picks up the scent of explosives ...
Breaking Biology Technology:Xybion Announces It Will Host International User Conference in Philadelphia 2Xybion Announces It Will Host International User Conference in Philadelphia 3Zerenex (ferric citrate) long-term Phase 3 study results published in JASN 2Zerenex (ferric citrate) long-term Phase 3 study results published in JASN 3Zerenex (ferric citrate) long-term Phase 3 study results published in JASN 4Stem Cells In Sports Injuries, Joints And Muscular Pain 2Stem Cells In Sports Injuries, Joints And Muscular Pain 3Nano-sized chip 'sniffs out' explosives far better than trained dogs 2
... Canary Foundation, a,nonprofit organization that funds research in early ... Sam Gambhir, has,been elected as a new member of ... one of the highest honors in the fields of ... National Academy of,Sciences, serves as adviser to the nation ...
... MOUNTAIN VIEW, Calif., Oct. 21 An ... difficult to treat allures clinicians,to the approach of ... potential, stem cell therapies are believed to treat ... at a fast pace; however,both adult and embryonic ...
... Findings confirm that NanoBio,s nanoemulsion technology is effective when ... used in therapeutic applications and vaccines, ... announced,today that it will present compelling new data in ... preclinical development programs,in onychomycosis, herpes labialis, cystic fibrosis and ...
Cached Biology Technology:Canary Foundation's Dr. Sanjiv Sam Gambhir Elected to the National Academies Institute of Medicine 2Innovation and Strong Therapeutic Potential Seen in Adult Stem Cells, According to Frost & Sullivan 2Innovation and Strong Therapeutic Potential Seen in Adult Stem Cells, According to Frost & Sullivan 3NanoBio to Announce Key Clinical and Preclinical Data in Nine Presentations at ICAAC/IDSA 2008 2
... an effort to help promote genomics-based research with ... ORFmer set that contains PCR primers to amplify ... strain1. In addition, primer pairs are included to ... Mu50 and N315 strains of S. aureus. The ...
... your life easier. It offers a wide array of ... balance. *Instruments supported: ... XS, XP, PR, SR, PG-S, PG, SG, AT, MT, ... User guidance on the balance ...
High affinity antibody reacting with S-100 ab heterodimer. Could be used for Western blotting application and immunoassay....
ZBP-89 (S-15)...
Biology Products: