Navigation Links
Scientists glimpse dance of skeletons inside neurons
Date:9/13/2010

Scientists at Emory University School of Medicine have uncovered how a structural component inside neurons performs two coordinated dance moves when the connections between neurons are strengthened.

The results are published online in the journal Nature Neuroscience, and will appear in a future print issue.

In experiments with neurons in culture, the researchers can distinguish two separate steps during long-term potentiation, an enhancement of communication between neurons thought to lie behind learning and memory. Both steps involve the remodeling of the internal "skeletons" of dendritic spines, small protrusions on the surface of a neuron that receive electrical signals from neighboring cells.

The results hint at why people with Williams syndrome, a developmental disorder caused by a deletion of several genes, including one that alters dendritic spine remodeling, have such an unusual blend of cognitive strengths and weaknesses.

The senior author of the paper is James Zheng, PhD, professor of cell biology and neurology at Emory University School of Medicine. The paper's co-first authors are graduate student Jiaping Gu, now a postdoctoral researcher at New York University, postdoc Chi Wai Lee and graduate student Yanjie Fan.

"We've been looking at the remodeling of dendritic spines, which is a fundamental process for reshaping circuits in the brain," Zheng says. "The anatomy of dendritic spines is altered in many diseases, such as fragile X syndrome and schizophrenia, as well as neurodegenerative disorders like Alzheimer's."

During the process of long-term potentiation, dendritic spines both enlarge and display a greater density of neurotransmitter receptors, the receiver dishes that allow neurons to detect the waves of chemicals other neurons are sending them.

Zheng's team studied this process by engineering a type of neurotransmitter receptor to be fluorescent when introduced into neur
'/>"/>

Contact: Holly Korschun
hkorsch@emory.edu
404-727-3990
Emory University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Jefferson scientists deliver toxic genes to effectively kill pancreatic cancer cells
2. Scientists identify novel inhibitor of human microRNA
3. Argonne scientists peer into heart of compound that may detect chemical, biological weapons
4. MU scientists go green with gold, distribute environmentally friendly nanoparticles
5. Scientists identify gene that may contribute to improved rice yield
6. Scientists discover why a mothers high-fat diet contributes to obesity in her children
7. MU scientists see how HIV matures into an infection
8. Earth scientists keep an eye on Texas
9. Thinking it through: Scientists call for policy to guide biofuels industry toward sustainability
10. Scientists identify a molecule that coordinates the movement of cells
11. Scientists Find new migratory patterns for Mediterranean and Western Atlantic bluefin tuna
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/22/2014)... allergic to dust mites (and chances are you are), ... the University of Iowa have developed a vaccine that ... immune response. In animal tests, the nano-sized vaccine package ... to the allergens, according to the paper, published in ... Journal . One big reason why it works, ...
(Date:7/22/2014)... An international collaboration known as the ,1000 Bull Genomes ... beef and dairy cattle while also improving animal health ... based on sequencing the whole genomes of 234 individual ... millions -- are reported in the journal Nature ... could use this information to reduce or eliminate hereditary ...
(Date:7/22/2014)... that split light with uncanny precision are key ... computers that manipulate light instead of electricity. But ... etching them with a precise beam of electrons, ... researchers at Princeton and Columbia universities have proposed ... customize and grow these specialized materials, known as ...
Breaking Biology News(10 mins):Researchers create vaccine for dust-mite allergies 2Whole-genome sequencing of bulls in key beef and dairy breeds 2Technique simplifies the creation of high-tech crystals 2Technique simplifies the creation of high-tech crystals 3
... -- The Damon Runyon Cancer Research Foundation, a ... researchers and innovative cancer research, named 11 new ... Award Committee review. The recipients of this ... basic and translational cancer research in the laboratories ...
... just how big a carbon footprint is created by travel to ... kind in the world to look at this issue. It also ... as: Setting up audio/video facilities at airports ... to airports to see off friends and family., Situating luggage-drop facilities ...
... NARRAGANSETT, R.I. January 21, 2010 The bubbles ... and tickle your nose are exhibiting a behavior quite similar to ... physicist Helen Czerski. But while the champagne bubbles ... cause clouds to form and affect the climate. "Bubbles are ...
Cached Biology News:Damon Runyon Cancer Research Foundation awards prestigious fellowships to 11 top young scientists 2Damon Runyon Cancer Research Foundation awards prestigious fellowships to 11 top young scientists 3Saying goodbye at airports the green way 2Bubble physicist counts bubbles in the ocean to answer questions about climate, sound, light 2Bubble physicist counts bubbles in the ocean to answer questions about climate, sound, light 3
(Date:7/22/2014)...   BioTE Medical , a leading provider ... pellets, today announced the addition of Dr. ... Rouzier is joining the BioTE Medical Advisory Board ... Rouzier was residency trained in Family Medicine and ... certified emergency physician still practicing at a large ...
(Date:7/22/2014)... 2014 CTD Holdings, Inc. (OTCQB:CTDH), a ... device, cosmetics, and other markets, announced today that it ... of qualified private investors led by Novit L.P., an ... The transaction involved the signing of a Securities Purchase ... Common Stock at a price per share of $1.00, ...
(Date:7/22/2014)... (PRWEB) July 22, 2014 ... attendance at the 2014 NCSL International Workshop and ... #423 will feature CONDEC pressure instrumentation, OIML M1 ... and the new, customized sets, Essential Weights™. , ... promote cooperative efforts in solving the common problems ...
(Date:7/22/2014)... Two new members were elected to ... its annual Shareholders Meeting on June 13: Kerry R. ... PFM Group, and Stephen T. Zarrilli, President and CEO ... election of Michael A. DiPiano, Managing General Partner of ... P. Jaffe, Esq., of Duane Morris LLP, as Director ...
Breaking Biology Technology:Dr. Neal Rouzier Joins BioTE Medical 2Dr. Neal Rouzier Joins BioTE Medical 3CTD Holdings Closes $1.725 Million Private Placement 2CTD Holdings Closes $1.725 Million Private Placement 3Rice Lake Weighing Systems Showcases Metrology Solutions for the 2014 NCSL International Workshop & Symposium 2Two New Members Elected to University City Science Center Board of Directors 2Two New Members Elected to University City Science Center Board of Directors 3
... 10 Endologix, Inc. (Nasdaq: ELGX ), developer of ... Lemaitre, former President and CEO of CoreValve, has joined the ... now has four independent directors and three non-independent directors. , ... pleased to welcome Dan Lemaitre to the Endologix Board of ...
... , ... signs of growth, Sidoti & Company, Wall Street,s largest, fastest-growing small cap ... unique investment opportunities within the micro cap market at the firm,s ... Grand Hyatt Hotel in New York, NY. , "Micro cap ...
... 10 /PRNewswire-FirstCall/ - YM BioSciences Inc. (NYSE Amex: YMI ... identifies and advances a diverse portfolio of promising cancer-related products ... the proposed transaction which would result in the merger of ... October 5, 2009. The board of directors of Cytopia has ...
Cached Biology Technology:Endologix Appoints Dan Lemaitre to its Board of Directors 2Technology, Biotech, Energy and Transportation Among the Industries to be Featured at Sidoti & Company's First Annual 2010 Micro Cap Conference 2YM BIOSCIENCES OFFER FOR CYTOPIA APPROVED TO PROCEED TO SHAREHOLDER VOTE BY AUSTRALIAN COURT 2YM BIOSCIENCES OFFER FOR CYTOPIA APPROVED TO PROCEED TO SHAREHOLDER VOTE BY AUSTRALIAN COURT 3YM BIOSCIENCES OFFER FOR CYTOPIA APPROVED TO PROCEED TO SHAREHOLDER VOTE BY AUSTRALIAN COURT 4
SHP-2 Antibody...
Anti human PPAR gamma2 mouse monoclonal antibody...
... The antiserum has been tested on tissue ... staining pattern obtained with AB1773 corresponds to ... with probes to GLYT2 mRNA and to ... Preabsorption of the antiserum with the immunogen ...
Mouse monoclonal [RIZ1723] to PRDM2/RIZ...
Biology Products: