Navigation Links
Scientists from USC and NYU design a molecule that blocks cancer growth in mice
Date:5/13/2014

A team of researchers from USC and NYU has developed and patented a small molecule that interferes with cancer progression with minimal side effects.

The molecule prevents two critical proteins from interacting by mimicking the surface topography of one protein like wearing a mask which tricks the other protein into binding with it. This stops a so-called "transcription factor" that controls the transcription of genetic information. That transcription factor is what would have created an aberrant gene expression, contributing to the cancer growth.

Because of the molecule's precision in targeting the protein interaction, the treatment does not appear to produce any side effects when tested animal tumor models.

"This complex represents one of the key focal points in the tumor-promotion," said Bogdan Olenyuk, assistant professor of pharmacology and pharmaceutical sciences at the USC School of Pharmacy, and one of two corresponding authors on a paper about the work. "However, targeting it for therapeutic intervention was a major challenge, since transcription factors do not possess the necessary topographical structures to make them good targets for mimicking drugs.

Instead, the team focused on blocking one of the transcription factor's binding partners a large protein with complex topography that makes it an easier, more "druggable" target.

Teams of researchers from USC and NYU collaborated on the study. Olenyuk led the USC group, which included graduate students Ivan Grishagin and researcher Hanah Mesallati. Paramjit Arora, professor of chemistry at NYU and co-corresponding author on the paper, lead the NYU group, which included graduate student Brooke Bullock Lao and Thomas Brewer.

Their study appears this week in the Proceedings of the National Academy of Sciences (PNAS). The researchers have filed patent applications for the new design, which has already attracted the interest of several ph
'/>"/>

Contact: Robert Perkins
perkinsr@usc.edu
213-740-9226
University of Southern California
Source:Eurekalert

Page: 1 2

Related biology news :

1. Scientists discover a natural molecule to treat type 2 diabetes
2. 35 scientists receive early career research program funding
3. Leading cfaed scientists organize international workshop about DNA-based microchips
4. Scientists link honeybees changing roles throughout their lives to brain chemistry
5. Scientists challenge FIFA: Save the 3-banded armadillo
6. Arizona Sate University scientists take steps to unlock the secrets to the fountain of youth
7. Salk scientists reveal circuitry of fundamental motor circuit
8. Scientists propose amphibian protection
9. Scientists figure out staying power of HIV-fighting enzyme
10. Scientists discover endogenous dendritic cell-derived interleukin-27 promotes tumor growth
11. Two San Diego scientists elected to the National Academy of Sciences
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2014)... called TX Invasives is now available from the Lady ... at Austin for identifying harmful non-native plant, insect and ... the United States cause about $137 billion in economic ... clog waterways, kill native plants and more. , "By ... reporting where invasive species occur, we,re more likely to ...
(Date:8/28/2014)... America (ESA) is pleased to announce the selection of ... Society. Honorary Membership acknowledges those who have served ESA ... the affairs of the Society that has reached an ... the ESA Governing Board and then voted on by ... the Awards Ceremony at Entomology 2014, ESA,s Annual Meeting ...
(Date:8/28/2014)... have identified a handful of bacterial culprits that may ... and ulcerative colitis, using patients, own intestinal immune responses ... 28 in the journal Cell . , Trillions ... plays a critical role in the development and progression ... number of bacterial species affect a person,s susceptibility to ...
Breaking Biology News(10 mins):Mobile app makes ID of harmful plants, insects in Texas a snap 2Fred Baxendale selected as Honorary Member of the Entomological Society of America 2Yale study identifies possible bacterial drivers of IBD 2
... conodonts early vertebrates that kept their skeleton in their ... teeth (see image) and, like teeth, they were often worn ... conodonts evolved the first vertebrate dentitions. Scientists know that ... they are microscopic about 2 to 0.2 mm long ...
... A parking lot at the edge of the University ... emerging concern for the environment and human health. ... journal Environmental Science & Technology , has found that ... lots throughout the nation, has significant health and ecosystem implications. ...
... For the first time, scientists at the University of ... progenitor cells using induced pluripotent stem (iPS) cells derived ... retina structures showed the capacity to form layers of ... development and these cells possessed the machinery that ...
Cached Biology News:Size isn't everything -- it's how sharp you are 2UNH research adds to mounting evidence against popular pavement sealcoat 2Scientists produce eye structures from human blood-derived stem cells 2
(Date:8/28/2014)... Nevada City, CA (PRWEB) August 28, 2014 ... and sanitation products for the food processing industry, is ... conducting a side-by side comparison of the E2 soap ... Q E2 Sanitizing Foam Soap . Hand hygiene ... pathogens in the food processing environment. Six key criteria ...
(Date:8/28/2014)... Best Sanitizers, Inc., the first company ... sanitizer, asks food processors and food handling professionals to ... they’re currently using to Best Sanitizers’ Alpet® E3 ... to fighting cross-contamination and the spread of pathogens in ... are key criteria that make a hand sanitizer most ...
(Date:8/28/2014)... 28, 2014 “This kit has an improved ... from 0 to 150 ppb,” said Mark Tess, PhD, Mycotoxin ... benefit to plant owners and USDA-GIPSA inspection agencies that have ... Testing can take place in a matter of minutes with ... plant test the feed and grain before accepting it, but ...
(Date:8/28/2014)... LAFAYETTE, Ind. A new research platform ... properties of tiny structures undergoing stress and ... to improve designs for microelectronics and batteries., ... reveals information about how heating and the ... mechanical properties. Researchers have discussed the merits ...
Breaking Biology Technology:Best Sanitizers, Inc. Asks Food Industry Professionals: With Fall Harvest On the Way, Is Your E2 Hand Soap Up to the Task? 2Food Processors and Food Handlers are Encouraged to Prepare for Fall Harvest by Evaluating Their Current Hand Sanitizer Using Nine Key Criteria 2Food Processors and Food Handlers are Encouraged to Prepare for Fall Harvest by Evaluating Their Current Hand Sanitizer Using Nine Key Criteria 3New analytical technology reveals 'nanomechanical' surface traits 2New analytical technology reveals 'nanomechanical' surface traits 3
... UCLA today announced the launch of the Mattel ... of personalized medicine for children, including the opportunities ... the world,s first dedicated solely to nanomedicine and ... a nanopediatrics program? Because children are not small ...
... 17 Bunge Limited,(NYSE: BG ), an integrated, ... the quarter ended September 30, 2008, on Thursday,October 23, ... management will host a conference call at 10:00 a.m.,EDT ... To listen to the conference call, please dial ...
... American Society of Anesthesiologists Annual Meeting as Masimo ... Oxygen Content (SpOC) monitor with live ... ... the inventor,of Pulse CO-Oximetry(TM) and Measure-Through-Motion-and-Low-Perfusion pulse,oximetry, announced today that ...
Cached Biology Technology:Mattel Children's Hospital UCLA launches program in nanopediatrics 2Bunge Limited Schedules Third Quarter 2008 Earnings Release and Conference Call 2Five New Clinical Studies Show Value of Masimo PVI & PI 2Five New Clinical Studies Show Value of Masimo PVI & PI 3Five New Clinical Studies Show Value of Masimo PVI & PI 4Five New Clinical Studies Show Value of Masimo PVI & PI 5
Mouse NOV/CCN3 Affinity Purified Polyclonal Ab...
SNARE associated protein snapin, clone MGC:2717...
HiTrap NHS-activated HP, 1 x 5 ml. Category: Chromatography Systems & Accessories, Systems....
Human Serpin A8/AGT Affinity Purified Polyclonal Ab Keywords: Ang II, AngII, Hypertension, Salt Homeostasis, Pre-eclampsia...
Biology Products: