Navigation Links
Scientists from USC and NYU design a molecule that blocks cancer growth in mice
Date:5/13/2014

A team of researchers from USC and NYU has developed and patented a small molecule that interferes with cancer progression with minimal side effects.

The molecule prevents two critical proteins from interacting by mimicking the surface topography of one protein like wearing a mask which tricks the other protein into binding with it. This stops a so-called "transcription factor" that controls the transcription of genetic information. That transcription factor is what would have created an aberrant gene expression, contributing to the cancer growth.

Because of the molecule's precision in targeting the protein interaction, the treatment does not appear to produce any side effects when tested animal tumor models.

"This complex represents one of the key focal points in the tumor-promotion," said Bogdan Olenyuk, assistant professor of pharmacology and pharmaceutical sciences at the USC School of Pharmacy, and one of two corresponding authors on a paper about the work. "However, targeting it for therapeutic intervention was a major challenge, since transcription factors do not possess the necessary topographical structures to make them good targets for mimicking drugs.

Instead, the team focused on blocking one of the transcription factor's binding partners a large protein with complex topography that makes it an easier, more "druggable" target.

Teams of researchers from USC and NYU collaborated on the study. Olenyuk led the USC group, which included graduate students Ivan Grishagin and researcher Hanah Mesallati. Paramjit Arora, professor of chemistry at NYU and co-corresponding author on the paper, lead the NYU group, which included graduate student Brooke Bullock Lao and Thomas Brewer.

Their study appears this week in the Proceedings of the National Academy of Sciences (PNAS). The researchers have filed patent applications for the new design, which has already attracted the interest of several ph
'/>"/>

Contact: Robert Perkins
perkinsr@usc.edu
213-740-9226
University of Southern California
Source:Eurekalert

Page: 1 2

Related biology news :

1. Scientists discover a natural molecule to treat type 2 diabetes
2. 35 scientists receive early career research program funding
3. Leading cfaed scientists organize international workshop about DNA-based microchips
4. Scientists link honeybees changing roles throughout their lives to brain chemistry
5. Scientists challenge FIFA: Save the 3-banded armadillo
6. Arizona Sate University scientists take steps to unlock the secrets to the fountain of youth
7. Salk scientists reveal circuitry of fundamental motor circuit
8. Scientists propose amphibian protection
9. Scientists figure out staying power of HIV-fighting enzyme
10. Scientists discover endogenous dendritic cell-derived interleukin-27 promotes tumor growth
11. Two San Diego scientists elected to the National Academy of Sciences
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... professor and Howard Hughes Medical Institute investigator, and ... recipients in the 2014 round of grants from ... BRAIN (Brain Research through Advancing Innovative Neurotechnologies) Initiative ... September 30, provides more than $3 million in ... , The BRAIN Initiative, launched last year, is ...
(Date:9/30/2014)... German . FRANKFURT. ... in the world. Because they grow underground, people use trained ... of truffles is not only of interest to gourmets. A ... the Goethe University Frankfurt have discovered that the smell of ... trapped inside truffle fruiting bodies. , White truffles from the ...
(Date:9/30/2014)... hope: A new research report published in October 2014 ... explains how scientists developed a synthetic version of a ... in human and mouse eggs similar to the natural ... fertilization. , "We believe that the results of this ... of human fertilization by providing a precise answer to ...
Breaking Biology News(10 mins):Salk scientists receive $3 million for BRAIN Initiative grant 2On the trail of the truffle flavor 2Synthetic sperm protein raises the chance for successful in vitro fertilization 2
... used topically in many skin creams and cosmetics because ... Now, new research just published in the Journal of ... and how it might actually benefit skin from the ... cocoa may actually help improve the appearance of women's ...
... is the only culprit in the steady increase in the ... challenged by a scientist speaking at the 22nd annual conference ... Prague, Czech Republic, Wednesday 21 June 2006. Professor ... that his research had shown that improved nutrition, both maternal ...
... (LANP) have unveiled the "nanoegg," the latest addition ... of the versatile nanoshell, nanoeggs are asymmetric specks ... harnessed for molecular imaging, medical diagnostics, chemical sensing ... July 18 issue of the Proceedings of the ...
Cached Biology News:New study reveals components of cocoa may enhance the appearance of the skin 2Nutrition a major factor in rise in twin pregnancies 2Nutrition a major factor in rise in twin pregnancies 3Rice scientists unveil 'nanoegg' 2
(Date:10/1/2014)... 2014 Today the National Institutes ... grants for the Brain Research through Advancing Innovative ... develop and revolutionize new methods of understanding the ... brain. This first round of grants totaling $46 ... allocated to more than 100 investigators in 15 ...
(Date:10/1/2014)... Washington, USA (PRWEB) September 30, 2014 ... yet efficient arrangements that have evolved in nature over ... biomimetic and bioinspired materials for applications in biophotonics ... Biomedical Optics . The journal is published by SPIE, ... SPIE Digital Library. Several of the peer-reviewed articles are ...
(Date:10/1/2014)... Slone Partners , a national ... and Laboratory Testing industries, reported a 120% increase in ... level and above from July 2013 to July 2014. ... of rapid breakthroughs in diagnostics, reimbursement has failed to ... been forced to fold, consolidate, or carry on without ...
(Date:10/1/2014)... 2014 The U.S. Department of Labor ... University Edwardsville as part of the Trade Adjustment Assistance ... is co-administered by the Department of Labor and Department ... Labor Thomas E. Perez and Secretary of Education Arne ... training grants to nearly 270 colleges across the country. ...
Breaking Biology Technology:NIH Awards 15 Grants to CHI Members for BRAIN Initiative Research 2NIH Awards 15 Grants to CHI Members for BRAIN Initiative Research 3Biomimetic and bioinspired materials enable new healthcare options, reports Journal of Biomedical Optics 2Biomimetic and bioinspired materials enable new healthcare options, reports Journal of Biomedical Optics 3Slone Partners Meets Growing Demand as Industry Focuses on Reimbursement & Regulation 2U.S. Dept. of Labor Awards SIUE Nearly $10-Million Grant 2U.S. Dept. of Labor Awards SIUE Nearly $10-Million Grant 3U.S. Dept. of Labor Awards SIUE Nearly $10-Million Grant 4
... CLINTON, N.J. and JERUSALEM, July 6 Ikaria Holdings, ... Ikaria has entered into an agreement to obtain a ... treatment for preventing pathological cardiac remodeling following acute myocardial ... phase I/II clinical trial, is administered via the coronary ...
... /PRNewswire-FirstCall/ - avVaa World Health Care Products Inc. (Pink ... of nationally branded therapeutic, natural skin and health care ... an agreement with 3PL Worldwide, Inc., for all Order ... CEO explains that "3PL Worldwide offers true multichannel support ...
... July 6 /PRNewswire-FirstCall/ -- Verenium Corporation (Nasdaq: ... the $29.5 million of outstanding 8% Senior Convertible Notes due ... July 1, 2009 is effective as of 8:00 a.m. today. ... with holders of 87% of the Notes, which is above ...
Cached Biology Technology:IKARIA(R) to In-License BioLineRx's BL-1040 2IKARIA(R) to In-License BioLineRx's BL-1040 3avVaa World Health Care Products, Inc. Signs Agreement with 3PL Worldwide, Inc., for Order Management & Fulfillment for avVaa's Product 2Verenium Completes Amendment to 8% Senior Convertible Notes 2Verenium Completes Amendment to 8% Senior Convertible Notes 3Verenium Completes Amendment to 8% Senior Convertible Notes 4
Ps-Aeruginosa (IgA) -Ab EIA Sample Size: 100 l...
Request Info...
... bench time to just 15 minutes! The ... that can be drawn between this exciting new ... instant foods. Instant meals consumed by astronauts, ... and are reconstituted by adding water. The ...
...
Biology Products: