Navigation Links
Scientists fool bacteria into killing themselves to survive
Date:12/16/2008

Like firemen fighting fire with fire, researchers at the University of Illinois and the University of Massachusetts at Amherst have found a way to fool a bacteria's evolutionary machinery into programming its own death.

"The basic idea is for an antimicrobial to target something in a bacteria that, in order to gain immunity, would require the bacteria to kill itself through a suicide mutation," said Gerard Wong, a professor of materials science and engineering, of physics, and of bioengineering at the U. of I.

Wong is corresponding author of a paper accepted for publication in the Proceedings of the National Academy of Sciences. The paper is to be posted this week on the journal's Web site.

The researchers show that a synthetic "hole punching" antimicrobial depends on the presence of phosphoethanolamine, a cone-shaped lipid found in high concentrations within Gram-negative bacterial membranes. Although PE lipids are commandeered to kill the bacteria, without the lipids the bacteria would die, also.

"It's a Catch-22," Wong said. "Some mutations bacteria can tolerate, and some mutations they cannot tolerate. In this case, the bacteria would have to go through a mutation that would kill it, in order to be immune to these antimicrobials."

In their work, the researchers compared the survival of the bacterium Escherichia coli with that of a mutant strain of E. coli, which lacked PE lipids in its membrane. The fragile PE-deficient mutant strain out-survived the normal, healthy bacteria, when exposed to a "hole punching" synthetic antibiotic.

However, the opposite was true when both strains were exposed to tobramycin, a conventional metabolic antibiotic that targets the bacterial ribosomal machinery rather than the membrane.

The researchers first reported on compounds that functioned as molecular "hole punchers" last year in the Journal of the American Chemical Society. Their latest work further eluc
'/>"/>

Contact: James E. Kloeppel
diya@illinois.edu
217-333-5802
University of Illinois at Urbana-Champaign
Source:Eurekalert

Page: 1 2

Related biology news :

1. UK scientists working to help cut ID theft
2. Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
3. Comet probes reveal evidence of origin of life, scientists claim
4. Scientists link fragile X tremor/ataxia syndrome to binding protein in RNA
5. Male elephants get photo IDs from scientists
6. Scientists retrace evolution with first atomic structure of an ancient protein
7. Muscle mass: Scientists identify novel mode of transcriptional regulation during myogenesis
8. Carnegie Mellon scientists develop nanogels that enable controlled delivery of carbohydrate drugs
9. Clemson scientists shed light on molecules in living cells
10. Scientists tackle mystery mountain illness
11. T. rex quicker than Becks, say scientists
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... the Department of Energy,s Oak Ridge National Laboratory ... R&D Magazine in recognition of the year,s top ... tremendous value of our National Labs," said Secretary ... the National Labs continues to help our nation ... and technological innovations necessary to remain globally competitive." ...
(Date:7/11/2014)... Mills Canyon fire started near the City of Entiat ... local resources, the fire quickly grew to over 1,000 ... of the fire is under investigation by the Washington ... working with existing local resources in developing fire control ... Service (USFS), Washington State Department of Natural Resources, (WA ...
(Date:7/11/2014)... Chicago is creating a new professorship in tissue ... Institute for Molecular Engineering and the Marine Biological ... the Millicent and Eugene Bell Foundation., The Eugene ... the Institute for Molecular Engineering. That endowed chair ... the MBL,s Eugene Bell Center for Regenerative Biology ...
Breaking Biology News(10 mins):ORNL wins eight R&D 100s 2ORNL wins eight R&D 100s 3ORNL wins eight R&D 100s 4New professorship in tissue engineering links molecular engineering, marine biology 2
... The Asian Cancer Research Group (ACRG)an independent, ... Merck (known as MSD outside the United States ... world,s largest genomics organizationtoday announced the publication of ... hepatitis B virus (HBV) integration in hepatocellular carcinoma ...
... Organic Electronics research group at Linkping University previously developed ... ions, as well as biomolecules. Tybrandt has now succeeded ... a similar way to traditional silicon-based electronics. ... carrier consists of chemical substances with various functions. This ...
... are retreating rapidly with the ongoing global climate change. But ... glaciers can recuperate within a short timeframe if temperatures are ... Danish aerial photos combined with both old and modern satellite ... created international attention and have been published as a cover ...
Cached Biology News:ACRG and BGI report findings from genomics research on recurrent hepatitis B virus integration 2ACRG and BGI report findings from genomics research on recurrent hepatitis B virus integration 3Old aerial photos supply new knowledge on glaciers in Greenland 2Old aerial photos supply new knowledge on glaciers in Greenland 3
(Date:7/11/2014)... Research and Markets  has announced the addition of ... Analysis, Size, Share, Growth, Trends and Forecast to 2019" ... http://photos.prnewswire.com/prnh/20130307/600769 Transfection is a technique ... into cells. This technology helps the cells to regulate ... by affecting the nuclear genes. The transfection technology market ...
(Date:7/11/2014)... AZ (PRWEB) July 11, 2014 ... device company specializing in the soft tissue reconstruction ... All-Suture Anchor System for surgeries involving the shoulder ... fixation through a novel, inserter-controlled deployment method. The ... to partial deployment, anchor pull-out, or anchor displacement ...
(Date:7/10/2014)... Boston, Mass. (PRWEB) July 10, 2014 ... , today announced that Alan Swahn, a former vice ... Terascala’s executive team as vice president of marketing. Terascala’s ... from Dell and NetApp create the highest performance and ... has been appointed to guide Terascala’s channel expansion and ...
(Date:7/10/2014)... 10, 2014 Senior supply chain management ... associations, addressed the challenges of “Reducing Cost, Lead Time, ... through strategic sourcing. Describing the partnership of the Bio ... Chain Management Institute ( SCMI) of the University ... 24 at the Kroc Institute of Peace and Justice ...
Breaking Biology Technology:International Transfection Technology Market - Industry Analysis, Size, Share, Growth, Trends and Forecast to 2019 2Cayenne Medical Launches SureLock™ All-Suture Anchor System for Shoulder and Extremity Surgery 2Cayenne Medical Launches SureLock™ All-Suture Anchor System for Shoulder and Extremity Surgery 3Terascala Expands Executive Team 2Terascala Expands Executive Team 3Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 2Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 3Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 4
... HILL, N.C., April 10 Thought leaders ... Depot, Qualcomm,Nationwide and others will address new ... in today,s competitive economy at the 10th,Annual ... & Retaining Top Talent, sponsored by Best ...
... N.J., April 10 Pharmacopeia,(Nasdaq: PCOP ), ... novel,small molecule therapeutics, today announced that Leslie J. ... Officer and a member of the,Board of Directors ... was,effective April 9, 2008., Joseph A. Mollica, ...
... Thermo Fisher,Scientific Inc. (NYSE: TMO ) announced that ... of 2008 before the market opens on Thursday,April 24, ... same day at 9:00,a.m. Eastern Time., During the ... as well as future expectations. To listen, call (866) ...
Cached Biology Technology:Pharmaceuticals & Biotechs to Share Insights for Developing Leaders in a Fast-Paced, Competitive Industry 2Leslie J. Browne Resigns as President and Chief Executive Officer of Pharmacopeia, Inc. 2Leslie J. Browne Resigns as President and Chief Executive Officer of Pharmacopeia, Inc. 3Leslie J. Browne Resigns as President and Chief Executive Officer of Pharmacopeia, Inc. 4Thermo Fisher Scientific to Hold Earnings Conference Call on Thursday, April 24, 2008 2
... tubes are used to store 2.0 ml ... uniform walls for uniform heat transfer and ... caps. The O-rings are made of polyethylene ... from -55 to 150 degrees C. Supplied ...
Caspr2 Antigen: Fusion protein amino acids 96-1265 (extracellular domain) of human Caspr2 Accession Number: NP_054860...
... its new line of Protein Standards, a ... use in mass spectrometry, molecular biology, and ... are high quality purified proteins for use ... electrospray ionization mass spectrometry (ESI-MS). For ...
Determin interaction of your protein with Echelons lipids...
Biology Products: