Navigation Links
Scientists find the 'master switch' for key immune cells in inflammatory diseases
Date:1/16/2011

Scientists have identified a protein that acts as a "master switch" in certain white blood cells, determining whether they promote or inhibit inflammation. The study, published in the journal Nature Immunology, could help researchers look for new treatments for diseases such as rheumatoid arthritis that involve excessive inflammation.

Inflammatory responses are an important defence that the body uses against harmful stimuli such as infections or tissue damage, but in many conditions, excessive inflammation can itself harm the body. In rheumatoid arthritis, the joints become swollen and painful, but the reasons why this happens are not well understood.

Cells of the immune system called macrophages can either stimulate inflammation or suppress it by releasing chemical signals that alter the behaviour of other cells. The new study, by scientists from Imperial College London, has shown that a protein called IRF5 acts as a molecular switch that controls whether macrophages promote or inhibit inflammation.

The results suggest that blocking the production of IRF5 in macrophages might be an effective way of treating a wide range of autoimmune diseases, such as rheumatoid arthritis, inflammatory bowel disease, lupus, and multiple sclerosis. In addition, boosting IRF5 levels might help to treat people whose immune systems are compromised.

Researchers from Imperial College London previously developed anti-TNF treatments, a class of drug that is widely used as a treatment for rheumatoid arthritis. The drugs target TNF, an important signalling chemical released by immune cells to stimulate inflammatory responses. However, about 30 per cent of patients don't respond to anti-TNF drugs, so there is a serious need to develop more widely effective therapies.

Dr Irina Udalova from the Kennedy Institute of Rheumatology at Imperial College London, the senior researcher on the study, said:

"Diseases can affect which genes
'/>"/>

Contact: Sam Wong
sam.wong@imperial.ac.uk
44-020-759-42198
Imperial College London
Source:Eurekalert

Page: 1 2

Related biology news :

1. Jefferson scientists deliver toxic genes to effectively kill pancreatic cancer cells
2. Scientists identify novel inhibitor of human microRNA
3. Argonne scientists peer into heart of compound that may detect chemical, biological weapons
4. MU scientists go green with gold, distribute environmentally friendly nanoparticles
5. Scientists identify gene that may contribute to improved rice yield
6. Scientists discover why a mothers high-fat diet contributes to obesity in her children
7. MU scientists see how HIV matures into an infection
8. Earth scientists keep an eye on Texas
9. Thinking it through: Scientists call for policy to guide biofuels industry toward sustainability
10. Scientists identify a molecule that coordinates the movement of cells
11. Scientists Find new migratory patterns for Mediterranean and Western Atlantic bluefin tuna
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... 27, 2014  Pomerantz LLP has filed a ... or the "Company")(NYSE-MKT: PVCT) and certain of its ... District Court, Middle District of Tennessee ... a class consisting of all persons or entities ... December 17, 2013 and May 22, 2014, both ...
(Date:7/10/2014)... July 2, 2014 NXT-ID, Inc., (OTCQB: NXTD) a biometric authentication ... Mr. Gino Pereira was interviewed on July 1 ... Tampa Florida . Mr. Pereira discusses the company,s ... Harris and how the Wocket™ aims to replace a ... Cedric Harris tells Gino he has never ...
(Date:7/10/2014)... -- Fingerprint Cards, (FPC,s) new mobile ... An Asian OEM has selected FPC1021 for a flagship model ... 2014.   FPC is proud to announce this ... date for start of mass production in August 2014. FPC ... for delivery in the first half of July. The OEM ...
Breaking Biology News(10 mins):SHAREHOLDER ALERT: Pomerantz Law Firm Announces the Filing of a Class Action against Provectus Biopharmaceuticals, Inc. and Certain Officers - PVCT 2SHAREHOLDER ALERT: Pomerantz Law Firm Announces the Filing of a Class Action against Provectus Biopharmaceuticals, Inc. and Certain Officers - PVCT 3Security and Your Money: Tampa Bay Radio Host Cedric Harris Talks to NXT-ID CEO Mr. Gino Pereira about the Wocket Smart Wallet 2Security and Your Money: Tampa Bay Radio Host Cedric Harris Talks to NXT-ID CEO Mr. Gino Pereira about the Wocket Smart Wallet 3Security and Your Money: Tampa Bay Radio Host Cedric Harris Talks to NXT-ID CEO Mr. Gino Pereira about the Wocket Smart Wallet 4FPC Wins DW and Initial Ramp Order for FPC1021 Touch Sensor for Flagship Smartphone from Asian OEM 2
... Partnership with Facial Recognition Expert Supports Open, Innovative ... ... Lockheed Martin,[NYSE: LMT] further advanced its capabilities and offerings in ... recognition technology. The Cognitec agreement will enable closer,cooperation between the two ...
... millionth of a millimeter in diameter numerically dominate ... carbon dioxide uptake, fueling the marine food web ... study published in this weeks PLoS ONE by ... of scientists from MountAllison University, Sackville, New Brunswick, ...
... will expand urea deep placement (UDP)a technology that doubles the ... of rice land, reaching about 1.6 million farm families, in ... the insertion of large urea briquettes into the rice root ... use UDP can increase yields by 25% while using less ...
Cached Biology News:Lockheed Martin Advances Biometrics Portfolio Through Cooperation Agreement With Cognitec 2Variable light illuminates the distribution of picophytoplankton 2Bangladesh to dramatically expand technology that doubles efficiency of urea fertilizer use 2
(Date:7/11/2014)... , July 11, 2014 Research and ... Transfection Technology Market - Global Industry Analysis, Size, Share, ... their offering. http://photos.prnewswire.com/prnh/20130307/600769 ... nucleic acids (either DNA or RNA) into cells. This ... of cancer cells and protein metabolism by affecting the ...
(Date:7/11/2014)... /CNW/ - Sunovion Pharmaceuticals Canada Inc. (Sunovion) today announced ... for use as a once-daily adjunctive therapy for the ... are not satisfactorily controlled with conventional therapy.  APTIOM TM ... 18 years of age. Epilepsy is ... to Epilepsy Canada, it affects 0.6% of the population ...
(Date:7/10/2014)... Ouagadougou, Burkina Faso (PRWEB) July 10, 2014 ... Burkina Faso, today have access to an additional ... to increase access to contraception at all levels ... combining a lower-dose formulation of a widely used ... injection system. , Burkina Faso is the first ...
(Date:7/10/2014)... Cleveland, Ohio (PRWEB) July 10, 2014 ... in ion channel-expressing cell lines, and the gap that ... new cells that expand its industry-leading portfolio of validated ... focuses on ion channel-expressing cell lines, as ion channels ... able to control this activity creates the potential to ...
Breaking Biology Technology:International Transfection Technology Market - Industry Analysis, Size, Share, Growth, Trends and Forecast to 2019 2Sunovion Pharmaceuticals Canada Inc. Announces Health Canada Approval of APTIOM(TM) (eslicarbazepine acetate) as a Once-Daily Adjunctive Treatment for Partial-Onset Seizures in Patients with Epilepsy 2Sunovion Pharmaceuticals Canada Inc. Announces Health Canada Approval of APTIOM(TM) (eslicarbazepine acetate) as a Once-Daily Adjunctive Treatment for Partial-Onset Seizures in Patients with Epilepsy 3Sunovion Pharmaceuticals Canada Inc. Announces Health Canada Approval of APTIOM(TM) (eslicarbazepine acetate) as a Once-Daily Adjunctive Treatment for Partial-Onset Seizures in Patients with Epilepsy 4Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 2Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 3Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 4Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 5Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 6Leader in Ion Channel Research Announces Newly Validated and Re-Engineered Cells 2Leader in Ion Channel Research Announces Newly Validated and Re-Engineered Cells 3
... Crosse, Wis - If you follow Wisconsin's race ... might believe voters care primarily about gun control, the ... the proposed constitutional ban on gay marriage. , ,But ... problems that matter most to them, you get a ...
... back, we took a look at the results of the National ... time, we saw that the Midwest had two states in the top ... top 20 states. I promised to circle back with you to review ... Midwest fared in this ranking. , ,The NIH falls under the ...
... big thing in all organizations today. Being able to depend on ... whether or not you want to come to work or start ... and those who manage people. If you are working hard and ... ready to leave. Bosses can actually kill productivity in the workplace. ...
Cached Biology Technology:What citizens don't ask political candidates 2What citizens don't ask political candidates 3Midwest colleges strong contenders for NIH funds 2Midwest colleges strong contenders for NIH funds 3Midwest colleges strong contenders for NIH funds 4Midwest colleges strong contenders for NIH funds 5Business Worst Practices: A new best seller? 2Business Worst Practices: A new best seller? 3Business Worst Practices: A new best seller? 4
... microarrays are custom designed to meet your ... available: 8,455 features per array (2 arrays/1" ... per array (1 array/slide). Features ... - This extended length delivers higher ...
... designed for pathway studies, protein-protein interaction ... Studies built on the flexible and ... These microarrays are available as part ... Service. Custom Probe Content ...
... normal Mega Western Protein Array was developed ... Western Protein Arrays are manufactured using high ... sources. A protein sample from each of ... a Protein molecular weight marker on a ...
... 2D Multi-User Applications Package Superior Protein ... Range: The ProXPRESS 2D Proteomic Imaging System ... both proteomic and general life science research ... the use of all dyes in the ...
Biology Products: