Navigation Links
Scientists find surprising new influence on cancer genes
Date:2/24/2013

LA JOLLA, CA February 24, 2013 Small stretches of DNA in the human genome are known as "pseudogenes" because, while their sequences are nearly identical to those of various genes, they have long been thought to be non-coding "junk" DNA.

But now, a new study led by scientists at The Scripps Research Institute (TSRI) shows how pseudogenes can regulate the activity of a cancer-related gene called PTEN. The study also shows that pseudogenes can be targeted to control PTEN's activity.

Published in the latest issue of the journal Nature Structural & Molecular Biology, the team's findings suggest a much larger role for pseudogenes than previously thoughta discovery that changes our understanding of the internal landscape of living cells, adding a new layer of complexity to an already crowded topography marked by multiple, overlapping, interacting gene networks.

Understanding how pseudogenes interact and control gene networks in the human body may lead to new ways of addressing diseases tied to problems that arise due to disruptions in these gene networks, said TSRI scientist Kevin Morris, PhD, who led the research in collaboration with scientists at the Karolinska Institute in Stockholm, Sweden, and The University of New South Wales in Sydney, Australia.

"This has improved our knowledge of how genes in cancer are regulated and how we may now be able to control them," Morris said.

Genes and Pseudogenes at Work

The focus of the human genome project, which decoded our entire DNA sequence a decade ago, was largely on genesthe genetic sequences that encode proteins and thus control processes that govern and regulate all biological functions. But these genes are only a small part of the genome. The vast majority of DNA in the human genome is non-coding, meaning that it does not make protein.

In the early days of molecular biology, scientists called these vast stretches of DNA "junk" because
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Scientists find bone-marrow environment that helps produce infection-fighting T and B cells
2. MBL scientists find genes linked to human neurological disorders in sea lamprey genome
3. Scientists identify molecular system that could help develop treatments for Alzheimers disease
4. Scientists publish analysis of algae parasite impact on algae biofuel in PLOS ONE
5. UCLA scientists develop new therapeutics that could accelerate wound healing
6. Insects scientists and children meeting in Las Cruces, New Mexico
7. Brown University scientists to discuss resilience of coastal communities at AAAS
8. Going negative: Stanford scientists explore new technologies that remove atmospheric CO2
9. Biodiversity protects against disease, scientists find
10. Scientists develop improved fire management tools for Africas savannas
11. NTU Provost receives prestigious Imperial College fellowship joining the ranks of top UK scientists
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists find surprising new influence on cancer genes
(Date:8/22/2014)... basic and clinical research and technological advances, the ... offensive spanning multiple fronts. , Work happening in ... find new and more selective therapies for cancer. ... specific enzyme overexpressed in certain cancersand they have ... , Chemistry professor Christopher Cairo and his team ...
(Date:8/22/2014)... American consumers will finally be able to purchase fuel ... as zero-emissions vehicles, most of the cars will run ... that contributes to global warming. , Now scientists at ... uses an ordinary AAA battery to produce hydrogen by ... through two electrodes that split liquid water into hydrogen ...
(Date:8/21/2014)... Nxt-ID, Inc. (OTCQB: NXTD), a biometric authentication ... today that its shares of common stock and the ... its proposed underwritten public offering of common stock and ... Capital Market, subject to closing of its proposed underwritten ... will trade under the symbol "NXTD" and "NXTDW," respectively. ...
Breaking Biology News(10 mins):New enzyme targets for selective cancer therapies 2New enzyme targets for selective cancer therapies 3Stanford scientists develop a water splitter that runs on an ordinary AAA battery 2Stanford scientists develop a water splitter that runs on an ordinary AAA battery 3Nxt-ID Approved for NASDAQ Capital Market Listing 2Nxt-ID Approved for NASDAQ Capital Market Listing 3
... warming in alpine regions is putting pressure on a rare ... released in Climatic Change Letters . In ... of Montana, U.S. Fish and Wildlife Service and National Park ... warning indicators of climate warming in mountain ecosystems. The glaciers ...
... Coastal mangrove forests store more carbon than almost any ... by a team of U.S. Forest Service and university ... Nature Geoscience . ( www.nature.com/naturegeoscience.com ) A ... and Northern research stations, University of Helsinki and the ...
... (April 4, 2011) An international team of researchers ... alcohol consumption, according to a new study published online ... of the National Academy of Sciences . ... that influence alcohol drinking behavior. Study contributors Danielle ...
Cached Biology News:Mangroves among the most carbon-rich forests in the tropics 2Gene involved in predisposition to alcohol consumption identified 2
(Date:8/21/2014)... 2014 Deep Research Report ... professional and in-depth research report on the ... Seaweed Fertilizer information, including Seaweed Fertilizer definition, ... well as industry overview. This research covers ... as well as global industry analysis covering ...
(Date:8/21/2014)... , Aug. 21, 2014 Telomere Biosciences, ... their Nutraceutical "TELO-20 for Dogs" with Telomerase ... supplement in the world for dogs. Telomeres are ... chromosome in the body. A wealth of ground-breaking ... in Telomere Science and Aging, including Nobel laureates, ...
(Date:8/21/2014)... Aug. 21, 2014 Mathematic studies at the ... , and funded by the Jeffrey Epstein VI Foundation ... can be visually identified for elimination. These aggressive cells are ... which shows a topological map of what to look for ... research, for while tumor cells can be extracted from biopsy, ...
(Date:8/21/2014)... 2014  Four-dimensional (4-D) printing develops materials that ... stimuli such as changes in temperature. This advanced ... in multiple industries.  In the near future, 4-D ... objects ranging from human organs to parts used ... Logo - http://photos.prnewswire.com/prnh/20140820/138289 ...
Breaking Biology Technology:Internationals Seaweed Fertilizer Industry 2014 Development Trend Analysis in New Research Study at DeepResearchReports.com 2Internationals Seaweed Fertilizer Industry 2014 Development Trend Analysis in New Research Study at DeepResearchReports.com 3Telomere Biosciences Announces: TELO-20 for Dogs, the World's First Telomere-Lengthening Supplement for Dogs, to Promote Healthy Aging and Longevity 2Telomere Biosciences Announces: TELO-20 for Dogs, the World's First Telomere-Lengthening Supplement for Dogs, to Promote Healthy Aging and Longevity 3Science Power Jeffrey Epstein and Harvard University Fund Project to Visually Stop Tumor Growth 2Frost & Sullivan: 4-D Printing to Usher in Age of Low-Labor, Fast-Paced Product Manufacturing 2Frost & Sullivan: 4-D Printing to Usher in Age of Low-Labor, Fast-Paced Product Manufacturing 3Frost & Sullivan: 4-D Printing to Usher in Age of Low-Labor, Fast-Paced Product Manufacturing 4
... FRANCISCO, Calif., Aug. 7 Anesiva,Inc. (Nasdaq: ANSV ... quarter and six months ended June 30, 2008., ... Anesiva as we,introduced Zingo(TM) in the U.S. pediatric hospital ... "In addition, I,m pleased,to report that our Phase 3 ...
... Inc.,(Nasdaq: ITMN ) today announced that Daniel G. ... the Canaccord Adams 28th Annual,Global Growth Conference in Boston ... To access a live audio webcast of the presentation, ... investor relations page of InterMune,s,corporate website at http://www.intermune.com ...
... 7 Medicsight PLC, a subsidiary,of MGT Capital ... industry leader in the,development of Computer-Aided Detection (CAD) ... received approval from the Brazilian regulatory,agency, Agencia Nacional ... David Sumner, Chief Executive of Medicsight, commented: "This ...
Cached Biology Technology:Anesiva Announces Second Quarter 2008 Financial Results and Update 2Anesiva Announces Second Quarter 2008 Financial Results and Update 3Anesiva Announces Second Quarter 2008 Financial Results and Update 4Anesiva Announces Second Quarter 2008 Financial Results and Update 5Anesiva Announces Second Quarter 2008 Financial Results and Update 6Anesiva Announces Second Quarter 2008 Financial Results and Update 7Anesiva Announces Second Quarter 2008 Financial Results and Update 8Medicsight Receives Brazilian State Food and Drug Administration Approval for ColonCAD Software 2Medicsight Receives Brazilian State Food and Drug Administration Approval for ColonCAD Software 3
... is a completely redesigned and updated version ... accepts the full line of well-proven Alpha ... in thermal performance as the DNA Engine ... easy transport of protocols among platforms. ...
... or for use in an automated line. ... disposable manifold provides greater ease, speed, convenience, ... StatMatic II can be connected to a ... fill a microplate with one-handed operation -- ...
... is a completely redesigned and updated version ... accepts the full line of well-proven Alpha ... in thermal performance as the DNA Engine ... easy transport of protocols among platforms. The ...
... standards consist of seven reduced, denatured proteins ... anhydrase, rabbit muscle GAPDH, bovine muscle actin, ... pIs ranging from 4.5 to 8.5 and ... These 2-D standards provide calibrated references for ...
Biology Products: