Navigation Links
Scientists find potential protein biomarkers for growth hormone
Date:6/17/2008

SAN FRANCISCO Ohio University scientists have identified several proteins in mice that might act as biomarkers for growth hormone. The research could be the first step to finding a more reliable way to detect recombinant human growth hormone (rhGH), which some athletes and teenagers use illegally to boost muscle and reduce fat.

At the Endocrine Society annual meeting in San Francisco today, scientists John Kopchick and Juan Ding presented a new study that pinpointed four proteins that significantly decreased or increased in the blood after exposure to bovine growth hormone, which is similar to human growth hormone.

The researchers injected six 6-month-old male mice with growth hormone for seven days. They studied blood samples from the mice and compared the results to six control animals. Kopchick and Ding scanned hundreds of plasma proteins and found four apoA1, transthyretin, clusterin and albumin that showed a strong reaction to growth hormone.

"They're in the blood, but we don't know if they're coming from liver, fat, muscle or the kidneys," said Kopchick, Goll-Ohio Professor of Molecular Biology with Ohio University's Edison Biotechnology Institute and College of Osteopathic Medicine.

Kopchick and Ding, a graduate student in biological sciences, are hopeful that the proteins could be viable biomarkers for growth hormone activity in humans as well.

"In mice we can control the variables and the environment, but humans are genetically diverse and have different lifestyles that impact growth hormone. So the results may point to future study in humans, but may not necessarily apply to humans yet," said Ding, who also is studying how to identify protein biomarkers for human aging.

Growth hormone is hard to detect because it has a serum half life of only 15 minutes. RhGH, an approved drug for individuals with growth hormone deficiency, also is identical to human growth hormone. The current method of detecting growth hormone, analyzing levels of insulin-like growth factor (IGF-1), isn't always accurate, the researchers said, as it is age and gender sensitive.

"If you have an 18-year-old Olympic athlete and a 38-year-old athlete, the IGF-1 values may look very different," said Kopchick, whose research is funded by the Ohio Eminent Scholars program and Ohio University's Edison Biotechnology Institute.

Because identification of rhGH misuse or abuse has high stakes it can make or break an athletic career the current method has too many variables to depend on, he said.

It's still early to tell whether these protein markers have the same age limitations, as the mice in the study live to only 2 years. But the markers may have longer half lives of several days, which would offer a wider testing window, he said.

Kopchick already is exploring how to detect rhGH in human blood and tissues through a project with Danish scientist J.O. Jorgensen. The team received a three-year grant from the World Anti-Doping Agency to look for protein markers in blood and tissues of human subjects exposed to rhGH or exercise, as well as patients with growth hormone disorders.


'/>"/>

Contact: Andrea Gibson
gibsona@ohio.edu
740-597-2166
Ohio University
Source:Eurekalert

Related biology news :

1. UK scientists working to help cut ID theft
2. Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
3. Comet probes reveal evidence of origin of life, scientists claim
4. Scientists link fragile X tremor/ataxia syndrome to binding protein in RNA
5. Male elephants get photo IDs from scientists
6. Scientists retrace evolution with first atomic structure of an ancient protein
7. Muscle mass: Scientists identify novel mode of transcriptional regulation during myogenesis
8. Carnegie Mellon scientists develop nanogels that enable controlled delivery of carbohydrate drugs
9. Clemson scientists shed light on molecules in living cells
10. Scientists tackle mystery mountain illness
11. T. rex quicker than Becks, say scientists
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/4/2017)... , Oct. 4, 2017  GCE Solutions, a global clinical research ... and document anonymization solution on October 4, 2017. Shadow is designed ... to comply with policy 0070 of the European Medicines Agency (EMA) ... ... Solutions ...
(Date:6/23/2017)... N.Y. , June 23, 2017  IBM (NYSE: ... dairy research, today announced a new collaboration using next-generation ... chances that the global milk supply is impacted by ... Cornell University has become the newest academic institution to ... a food safety initiative that includes IBM Research, Mars, ...
(Date:5/6/2017)... 2017 RAM Group , Singaporean ... breakthrough in biometric authentication based on a ... to perform biometric authentication. These new sensors are based ... by Ram Group and its partners. This sensor will ... chains and security. Ram Group is a next ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... ComplianceOnline’s Medical Device Summit is back ... 8th June 2018 in San Francisco, CA. The Summit brings together current and former ... CEOs, board directors and government officials from around the world to address key issues ...
(Date:10/11/2017)... ... October 11, 2017 , ... ... implantation and pregnancy rates in frozen and fresh in vitro fertilization (IVF) ... and maternal age to IVF success. , After comparing the results from the ...
(Date:10/10/2017)... ... October 10, 2017 , ... Dr. Bob Harman, founder and CEO ... Diego Rotary Club. The event entitled “Stem Cells and Their Regenerative ... attendees. Dr. Harman, DVM, MPVM was joined by two human doctors: Peter B. ...
(Date:10/9/2017)... 2017  BioTech Holdings announced today identification and ... ProCell stem cell therapy prevents limb loss in ... demonstrated that treatment with ProCell resulted in more ... compared to standard bone marrow stem cell administration.  ... reduction of therapeutic effect.  ...
Breaking Biology Technology: