Navigation Links
Scientists find potential drug targets in deadly pediatric brain tumors
Date:4/6/2014

orative "precision medicine" clinical trial based at Dana-Farber/Boston Children's. This trial was specifically designed to make discoveries that would change the treatment for children with a type of high grade astrocytoma called diffuse intrinsic pontine glioma (DIPG), the most aggressive brain tumor in children. DIPGs develop in the brainstemthe seat of crucial, basic body functions that keep people aliveand are therefore impossible to remove safely with surgery.

Doctors and patients from more than 20 institutions have now joined this study, which requires taking a biopsy from 100 children, analyzing their tumor tissue using pathology and molecular testing, and planning treatment specifically for each patient based on the results. A goal of the study is to determine whether advanced DNA sequencing and other tools that search for abnormalities and biomarkers can be used to guide potential treatments.

"Instead of treating all the patients the same, this trial obtains a biopsy at the time of diagnosis and the treatment is determined by the expression pattern of the tumor," says Kieran.

Findings in the Nature Genetics study include analysis of biopsy samples from the first group of children enrolled in the trial. In all, 40 tumor specimens underwent sequencing; 25 were from patients with DIPG tumors, some of whom were on the trial.

Most of the tumors were found to harbor a mutation called K27M in the H3F3A protein that is a basic building block of the "epigenome." The effects of this mutation are termed epigenetic because they can change the level of gene activity without changing the structure of a gene's DNA. Mutations in H3F3A have recently been detected in a large percentage of pediatric high-grade astrocytomas, but effective drugs for this mutation have not yet been found.

However, the scientists found that H3F3A mutations always occurred with other mutations that could in theory be targeted by existing d
'/>"/>

Contact: Irene Sege
irene.sege@childrens.harvard.edu
617-919-7379
Dana-Farber Cancer Institute
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Columbia scientists identify key cells in touch sensation
2. Scientists say new computer model amounts to a lot more than a hill of beans
3. Behind the scenes of the IPCC report, with Stanford scientists
4. Scripps Florida scientists offer best practices nutrition measurement for researchers
5. Notre Dame scientists develop largest developmental proteomic data set for any animal
6. Research from CHORI scientists demonstrates first genome methylation in fruit fly
7. Harvard scientists visualize new treatments for retinal blindness
8. A*STAR scientists create stem cells from a drop of blood
9. Plant biology discovery furthers scientists understanding of plant growth and development
10. Tropical grassy ecosystems under threat, scientists warn
11. Scientists herd cells in new approach to tissue engineering
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists find potential drug targets in deadly pediatric brain tumors
(Date:7/21/2014)... species, investigators have found that migration routes are under ... which is published in Ecology Letters , was ... of a bird and allow its long distance movement ... exhibited increased variability in their migratory routes: some used ... the same routes as one parental group on fall ...
(Date:7/21/2014)... for the evolution of life are now being developed ... an evolving system of species. Specifically, a recent model ... Finland in Joensuu accounts for species interactions with various ... an improvement on previous, simpler models, which apply random ... EPJ E demonstrate that the resulting replicator ecosystems ...
(Date:7/21/2014)... Women,s Hospital (BWH) have developed a scalable, next-generation platelet ... The work is a major biomedical advancement that will ... is published July 21, 2014 in Blood . ... of functional human platelets with virtually no disease transmission ... that may allow us meet the growing need for ...
Breaking Biology News(10 mins):Refined biological evolution model 2Scientists successfully generate human platelets using next-generation bioreactor 2
... Envisat and the Italian Space Agency,s COSMO-SkyMed, scientists have ... the 6.3 earthquake that shook the medieval town of ... Scientists from Italy,s Istituto per il Rilevamento Elettromagnetico dell, ... Vulcanologia (INGV) are studying Synthetic Aperture Radar (SAR) data ...
... into how the deadly Hendra virus spreads promises to ... the future. CSIRO Livestock Industries, scientists working at ... have made a major breakthrough in better understanding how ... humans. Funded by the Australian Biosecurity ...
... BioMed Central,s 3rd Annual Research Awards were announced at ... The event was attended by shortlisted authors, eminent researchers ... journalists. The Research Awards, now in their ... made universally accessible by open access publication. The Awards ...
Cached Biology News:Satellites show how Earth moved during Italy quake 2Minimizing the spread of deadly Hendra virus 2Open access research celebrated 2
(Date:7/21/2014)... 21, 2014) The yield so far is small, ... a low-energy, solution-based mineral substitution process to make a ... in electronics and alternative energy devices. , A paper ... the July 21 issue of the journal Inorganic ... in the inorganic and nuclear chemistry fields. The paper ...
(Date:7/20/2014)... 20, 2014 NSG Precision Cells ... optics, and spectrophotometer calibration standards for ... has released many products that have transformed the ... been their solid-state calibration standards. , NSG’s solid-state ... their release in 2008. NSG started manufacturing ...
(Date:7/18/2014)... mostly neutral. That is, most of the atoms ... of electrons in the outer parts of atoms equals ... As one or more electrons are plucked away ... stronger positive pull from the nucleus. This enhanced ... that those electrons are less vulnerable to the distractions ...
(Date:7/18/2014)... CHICAGO, Ill. , July 18, 2014 ... an infographic highlighting AbbVie and Shire,s complementary ... combination. A copy of the ... website at:  http://www.abbvieinvestor.com/phoenix.zhtml?c=251551&p=irol-disclaimer-documents ... Takeover Code, a copy of this announcement ...
Breaking Biology Technology:Oregon chemists eye improved thin films with metal substitution 2How NSG Precision Cells Spectrophotometer Calibration Standards Makes NIR Work Easier 2How NSG Precision Cells Spectrophotometer Calibration Standards Makes NIR Work Easier 3Highly charged ions 2Highly charged ions 3Highly charged ions 4NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART, DIRECTLY OR INDIRECTLY, IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF SUCH JURISDICTION 2NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART, DIRECTLY OR INDIRECTLY, IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF SUCH JURISDICTION 3NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART, DIRECTLY OR INDIRECTLY, IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF SUCH JURISDICTION 4NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART, DIRECTLY OR INDIRECTLY, IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF SUCH JURISDICTION 5NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART, DIRECTLY OR INDIRECTLY, IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF SUCH JURISDICTION 6NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART, DIRECTLY OR INDIRECTLY, IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF SUCH JURISDICTION 7
... N.J., March 18 Medarex, Inc. (Nasdaq: MEDX ... the Needham & Company Cancer Therapeutics: Today & Tomorrow Conference ... The event will be webcast live and will be available ... www.medarex.com . An archived edition of the presentation will ...
... StartUpHire launched today as the job search engine dedicated ... backed companies. These are some of the most ... been difficult to identify. The StartUpHire website, ... be filtered by industry, geography, functional area, investor, and ...
... XTL Biopharmaceuticals Ltd. (Nasdaq: XTLB ; TASE: ... ("EGMs") held earlier today.All of the resolutions at the ... of Mark Allouche, Dafna Cohen, Yaron Diament, David Grossman, ... appointed Chairman. Dafna Cohen and Yaron Diament were ...
Cached Biology Technology:StartUpHire Launches Comprehensive Search Engine for Jobs at Venture-Backed Companies 2StartUpHire Launches Comprehensive Search Engine for Jobs at Venture-Backed Companies 3Extraordinary General Meetings Statement -- XTL Also Announces Board and Management Changes 2
Human sVCAM-1/CD106 ELI-PAIR Kit...
GLP-1 (HYB 147-12)...
... Custom Synthesis Service provides you ... to knockdown any gene. We ... base pairs with terminal dT ... other lengths of your choice. ...
EDG-1 Western blot control Source: Cell Lysate Application: Western Blotting Control...
Biology Products: