Navigation Links
Scientists find potential drug targets in deadly pediatric brain tumors
Date:4/6/2014

BOSTON, MA (April 6, 2014) -- Researchers studying a rare, always fatal brain tumor in children have found several molecular alterations that drive the cancer, according to a new study from scientists at Dana-Farber/Boston Children's Cancer and Blood Disorders Center and McGill University. The findings identify potential new targets for drug treatments.

The new research could help physicians choose targeted agents with a better chance of combating pediatric high-grade astrocytomas, which are extremely difficult to treat with radiation and surgery. The tumors have resisted treatment attempts with an estimated 250 chemotherapy drugs and combinations over the past 30 years, according to the investigators. Their study was published April 6 in Nature Genetics.

The scientists sequenced tumor biopsy samples and identified a number of mutations or errors in the DNA code. They also found epigenetic changes, which alter how genes are expressed. At least two of the new mutations might be susceptible to blocking by existing drugs, said the investigators. Other molecular targets that they uncovered currently lack specific drugs to attack them but provide new opportunities for future drug development.

These results begin to crack open the genetic "black box" of these tumors, which only now are yielding clues to the abnormal molecular changes that drive them.

"For the most malignant tumor in pediatrics, we finally are beginning to gain a handle on the development of this disease, which is critical to devising effective therapies," says Mark Kieran, MD, PhD, a neuro-oncologist and clinical director of the Brain Tumor Center at Dana-Farber/Boston Children's. Kieran and neuropathologist Keith Ligon, MD, PhD, of Dana-Farber/Boston Children's, are co-senior authors along with two researchers from McGill.

The findings are due in part to a project that began more than 10 years ago when clinicians came together to create a collab
'/>"/>

Contact: Irene Sege
irene.sege@childrens.harvard.edu
617-919-7379
Dana-Farber Cancer Institute
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Columbia scientists identify key cells in touch sensation
2. Scientists say new computer model amounts to a lot more than a hill of beans
3. Behind the scenes of the IPCC report, with Stanford scientists
4. Scripps Florida scientists offer best practices nutrition measurement for researchers
5. Notre Dame scientists develop largest developmental proteomic data set for any animal
6. Research from CHORI scientists demonstrates first genome methylation in fruit fly
7. Harvard scientists visualize new treatments for retinal blindness
8. A*STAR scientists create stem cells from a drop of blood
9. Plant biology discovery furthers scientists understanding of plant growth and development
10. Tropical grassy ecosystems under threat, scientists warn
11. Scientists herd cells in new approach to tissue engineering
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists find potential drug targets in deadly pediatric brain tumors
(Date:9/18/2014)... several disciplines will be celebrated tonight at the third ... improving the health of premature infants and in paving ... researchers, whose work was supported by the National Science ... Atomic Energy Commission, will be honored at a ceremony ... bipartisan group of Members of Congress will be on ...
(Date:9/18/2014)... September 18, 2014 Elsevier, a world-leading provider ... services, and the Australasian Research Management Society (ARMS), ... scientists at the 5th Scopus Young Researcher of ... earlier today at the National Convention Centre and ... was attended by guests representing Australia,s and New ...
(Date:9/18/2014)... ultimate form of camouflage: you don,t just blend in, ... not as uncommon as you might think. Kathryn Feller, ... that the larval life stages of many marine species ... anatomy that most creatures cannot make transparent. Feller explains ... each individual eye unit with an opaque pigment to ...
Breaking Biology News(10 mins):3rd annual Golden Goose award ceremony honors 8 researchers; Unusual work had big results 2Elsevier and Australasian Research Management Society award scientists at Scopus ceremony 2Transparent larvae hide opaque eyes behind reflections 2
... adults with the blood cancer mixed-lineage leukemia (MLL) typically have ... birthdays. Although there are varying causes of MLL, most cases ... and the AF4 genes. When the ... cancer-causing oncogene is created. Although researchers have known that the ...
... engineering holds great promise for the treatment of conditions ... injuries. However, bone and cartilage currently produced in ... the body so they,re not clinically viable. Dr. ... of Medicine & Dentistry at The University of Western ...
... 2008 -- A rat thought extinct for 11 million years ... new species discovered in the Greater Mekong Region of Southeast ... launched by World Wildlife Fund (WWF). First ... discovered or newly identified by science between 1997 and 2007 ...
Cached Biology News:Tracking the molecular pathway to mixed-lineage leukemia 2Building better bones and tissue in the lab 2Over 1,000 species discovered in the Greater Mekong in past decade 2
(Date:9/17/2014)...  MiMedx Group, Inc. (NASDAQ: MDXG ... patent protected regenerative biomaterials and bioimplants processed from ... peer-reviewed clinical study.    The study ... Clinical Trial Evaluating the Use of ... Compression Therapy vs. Multi-layer Compression Therapy Alone in ...
(Date:9/17/2014)... 2014 BioClinica®, Inc., a leading provider of ... three of its experts are speaking at the ... to be held September 28 to October 1 in ... also announced the innovative Compass technology, a ... trials acquired earlier this year, is up for the ...
(Date:9/17/2014)... 17, 2014 Intarcia Therapeutics, Inc. ... a study of the cost and predictability of non-adherence ... Annual Meeting of the European Association for the ... Christian Frois , Ph.D., of Analysis Group, Inc. ... planned Intarcia-sponsored, retrospective studies to characterize the prevalence of ...
(Date:9/17/2014)... , Sept. 17, 2014 /PRNewswire/ - SQI Diagnostics Inc. ... develops and commercializes proprietary technologies and products for advanced ... been approved for trading in the United ... is expected to commence on September 17, 2014 on ... continue to trade on the TSX Venture Exchange under ...
Breaking Biology Technology:MiMedx Multi-Center Randomized, Controlled VLU Clinical Study Published In Peer-Reviewed Journal 2MiMedx Multi-Center Randomized, Controlled VLU Clinical Study Published In Peer-Reviewed Journal 3MiMedx Multi-Center Randomized, Controlled VLU Clinical Study Published In Peer-Reviewed Journal 4BioClinica to Present at 20th Annual SCDM Conference 2BioClinica to Present at 20th Annual SCDM Conference 3Intarcia Reveals New Insights At EASD Meeting Characterizing The Burden Of Poor Control And Non-Adherence To Anti-Diabetic Therapies 2Intarcia Reveals New Insights At EASD Meeting Characterizing The Burden Of Poor Control And Non-Adherence To Anti-Diabetic Therapies 3Intarcia Reveals New Insights At EASD Meeting Characterizing The Burden Of Poor Control And Non-Adherence To Anti-Diabetic Therapies 4Intarcia Reveals New Insights At EASD Meeting Characterizing The Burden Of Poor Control And Non-Adherence To Anti-Diabetic Therapies 5SQI Diagnostics to begin Trading on the OTCQX Marketplace in the United States 2SQI Diagnostics to begin Trading on the OTCQX Marketplace in the United States 3
... Sept. 4, 2007 Computing researchers at Houston,s ... Technological University (NTU) today announced the formation of ... joint research initiative, valued at 4 million Singapore ... costs for embedded microchips -- special-purpose computer chips ...
... WARSAW, Ind., Sept. 4 ,Tutogen Medical, Inc. (Amex: ... implant products made from human (allograft) and animal,(xenograft) ... ZMH), a leader,in the orthopaedics industry, today announced ... a wholly owned subsidiary of Zimmer,Holdings, Inc., into ...
... 4 Telik, Inc.,(Nasdaq: TELK ) announced that ... Annual Bear Stearns Healthcare Conference in New York,City on ... (8:30 a.m.,Pacific time). Telik,s presentation will be webcast live ... http://www.telik.com, ,through September 18, 2007. Telik, Inc. ...
Cached Biology Technology:Rice, Nanyang Tech collaborate on sustainable nanoelectronics 2Rice, Nanyang Tech collaborate on sustainable nanoelectronics 3Tutogen Medical, Inc. and Zimmer Holdings, Inc. Announce Agreement for International Distribution of Biological Products 2Tutogen Medical, Inc. and Zimmer Holdings, Inc. Announce Agreement for International Distribution of Biological Products 3Tutogen Medical, Inc. and Zimmer Holdings, Inc. Announce Agreement for International Distribution of Biological Products 4Tutogen Medical, Inc. and Zimmer Holdings, Inc. Announce Agreement for International Distribution of Biological Products 5
14-3-3 tau Antibody Shipping Temperature: HOT Storage Temperature: -20C...
Rabbit polyclonal to Lck (phospho Y192) ( Abpromise for all tested applications). entrezGeneID: 3932 SwissProtID: P06239...
Goat polyclonal to Ephrin B2 ( Abpromise for all tested applications). entrezGeneID: 1948 SwissProtID: P52799...
Mouse monoclonal [RL13] to LAP1 ( Abpromise for all tested applications). SwissProtID: Q96NW7...
Biology Products: