Navigation Links
Scientists find new targets that could increase effectiveness of breast cancer treatments
Date:6/5/2014

JUPITER, FL, June 5, 2014 Scientists from the Florida campus of The Scripps Research Institute (TSRI) have found new targets for potential intervention in breast cancer. These new targets could eventually increase effectiveness and reduce the undesirable side effects associated with current treatments.

The study was published online ahead of print on June 5, 2014 by the journal Structure.

Approximately two out of three breast cancers are driven by receptors that bind the hormones estrogen and progesteronewhen the hormones bind to these receptors in cancer cells, they signal the cancer cells to grow. What makes the progesterone receptor therapeutically interesting is that it has two activation domainsAF1 and AF2. Normally, both are needed for full activation of the receptor.

"Using hydrogen-deuterium exchange technology, our study pinpoints just how AF2 communicates with AF1the first evidence of the long-range interaction between these two functional domains," said Patrick R. Griffin, a TSRI professor who led the study. "These findings support further research to look for promising small molecules that block that interaction."

The findings are especially important because in some mutations AF2 is deleted, yet the receptor still drives the cancer using its AF1 domain. Current drugs used for treating these cancers only target the AF2 domain, so with nothing to bind to, they do not work at all. While several studies have shown the importance of AF1, its binding domain is remarkably dynamic, frequently shifting shape and making it difficult to target with drugs.

In the new study, the scientists used an advanced technology known as hydrogen-deuterium exchange mass spectrometry (HDX) to measure the intricate interactions between the AF1 and AF2 domains of the progesterone receptor.

HDX mass spectrometry is a high-precision, high-sensitivity mapping technique that enabled the scientists to determine th
'/>"/>

Contact: Eric Sauter
esauter@scripps.edu
267-337-3859
Scripps Research Institute
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Scientists discover the basis of allergic reactions
2. MU scientists successfully transplant, grow stem cells in pigs
3. Scientists capture most detailed images yet of humans tiny cellular machines
4. NUS scientists demonstrate rare chemical phenomenon to harvest solar energy
5. Glow-in-the-dark tool lets scientists find diseased bats
6. Listening helps scientists track bats without exposing the animals to disease
7. Scientists control rapid re-wiring of brain circuits using patterned visual stimulation
8. Vines choke a forests ability to capture carbon, Smithsonian scientists report
9. Imaging scientists develop a better tool for tracking MS
10. Scientists map the worst times of day for people allergic to grass pollen
11. Scientists discover potential new target for cancer immunotherapy
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists find new targets that could increase effectiveness of breast cancer treatments
(Date:5/14/2015)... YORK , May 14, 2015 /PRNewswire/ ... in identity verification and online remote proctoring, ... a software-as-a-service (SaaS) company and creator of ... customers of the two companies will benefit ... in Canvas. As a fully ...
(Date:5/11/2015)... 11, 2015 Curemark LLC, a privately held ... a new Phase III double blind, randomized, placebo-controlled clinical ... CM-AT, on all children ages 3-8 with Autism. Previously, ... III double blinded clinical trial for CM-AT in children ... the digestive enzyme chymotrypsin. This new trial will help ...
(Date:5/7/2015)... Sweden , May 7, 2015 ... touch fingerprint sensors, FPC1022 and FPC1035, FPC,s smallest ... and FPC1035 are mainly considered for integration on ... size gives smartphone OEMs increased possibilities to integrate ... The decreased size also improves possibilities for module ...
Breaking Biology News(10 mins):Verificient and Instructure Announce Alliance Partnership to Provide Online Proctoring for K-12 and Higher Education Institutions 2Curemark, LLC, Launches New Phase III Trial in Expanded Population of Children with Autism 2FPC Introduces its Smallest Touch Fingerprint Sensors to Date 2
... making the public aware of the stark difference between ... from Professor Barry Brook, Director of the Research Institute ... Adelaide, Australia. In an opinion piece published today ... has urged scientists to stand up to those who ...
... press release is not and,must not be, directly or ... Africa or the United States of America. The,Offer is ... elsewhere,where their participation requires further offer documents, filings or,other ... This is a,translation of the original Swedish language press ...
... a leading supplier of broadband technology and biometrics software,has ... results,for the first quarter of 2008 on Thursday, May ... and CFO Rick Moberg will host the,earnings conference call., ... can be accessed on the,Investor Relations page of our ...
Cached Biology News:Scientists urged to make a stand on climate change 2Oberthur Technologies XPon Offer 2Aware Announces Q1 2008 Earnings Conference Call 2
(Date:5/21/2015)... May 21, 2015  Susan Hedstrom, Executive Director ... nonprofit organization dedicated to supporting research to advance ... announced today that FPWR has received the organization,s ... Shaulov contributed $1 million in support of ... "Our gift signifies ...
(Date:5/21/2015)... May 21, 2015 W. R. ... manufacturing facility in Worms, Germany has received good ... subsidiary of the International Pharmaceutical Excipient Council (IPEC) ... that produce its SYLOID® FP brand of pharmaceutical ... certification, following the Curtis Bay, Maryland (USA) and ...
(Date:5/21/2015)... 2015 /PRNewswire/ - RepliCel Life Sciences Inc. (TSX.V: ... company focused on the development of autologous cell ... the International Society for Cellular Therapy (ISCT) on ... currently in a Phase 1/2 clinical trial.  The ... from 5:30 PM to 7:00 PM local time, ...
(Date:5/20/2015)... MA (PRWEB) May 20, 2015 This ... history, especially for lawns. US Patented Pearl’s Premium ... for lawns around the country that are coming out ... that addresses a number of major global concerns related ... the “non-grass” grass – the alternative to the standard, ...
Breaking Biology Technology:The Foundation for Prader-Willi Research Receives $1M Contribution in Support of Clinical Initiatives 2Grace European Facility Receives GMP Excipient Certification for SYLOID® FP Silica Gel 2RepliCel to Present Unique Autologous Cell Treatment for Achilles Tendinosis at International Society for Cellular Therapy Conference 2RepliCel to Present Unique Autologous Cell Treatment for Achilles Tendinosis at International Society for Cellular Therapy Conference 3Breakthrough 4th Generation Low Maintenance Lawn Seed Offers Solution to California Drought 2
... familiar with these three words, after all that has happened ... shown the importance of being current with ones network security ... attacks came via the blaster worm, which took advantage of ... Following closely on its heels were Sobig, Nacha, and ...
... bread and butter of Wisconsins economic growth will be ... to transfer our best technology to the marketplace, controlling ... ensuring theres a 21st century infrastructure in place to ... to the equation, too, that may prove as vital ...
... WI- Frost & Sullivan has announced that Camtronics ... Corporation as the recipient of both the 2003 ... information management market and the 2003 Market Penetration Leadership ... , ,Outstanding achievements in these areas have helped ...
Cached Biology Technology:Athletics, pop culture and the arts 2Athletics, pop culture and the arts 3Camtronics Receives Health IT Awards 2
... delivers enhanced statistics and statistical interpretation ... improvement managers. As an accepted organizational ... simplifies statistics for novice users and ... experts. It offers a powerful JMP ...
... Choice Microsphere/Microarray Stabilizer is a is a ... This product is an aqueous solution ... buffer (phosphate buffered saline), pH 6.6 - ... of 0.02% methylisothiazolone and 0.02% bromonitrodioxane as ...
... Microarray plates are ideal for use as source ... handling applications (down to 5µl). These plates are ... design. Features 384 round ... 70µl well volume (cylindrical well), 55µl well ...
... is an aqueous-based mounting medium designed ... sections. Gel/Mount is especially recommended when ... or FluoroBlue. It can also be ... as fluorescein (FITC), Rhodamine (TMRITC) and ...
Biology Products: