Navigation Links
Scientists find new class of compounds with great potential for research and drug development
Date:5/15/2011

Scientists from The Scripps Research Institute have identified a class of compounds that could be a boon to basic research and drug discovery.

In a new study, published online in Nature Chemical Biology on May 15, 2011, the researchers show the new compounds powerfully and selectively block the activity of a large and diverse group of enzymes known as "serine hydrolases." Previously discovered serine hydrolase-blocking compounds have been turned into drugs to treat obesity, diabetes, and Alzheimer's disease, and are currently in testing as treatments for pain, anxiety, and depression.

"There are more than 200 serine hydrolases in human cells, but for most we've lacked chemical inhibitors of their activity," said team leader Benjamin F. Cravatt III, professor and chair of the Department of Chemical Physiology at Scripps Research and a member of its Skaggs Institute for Chemical Biology, "so we've had only a limited ability to study them in the lab or to block them to treat medical conditions. This new research allows us to greatly expand our list of these inhibitors."

A Scaffold on Which to Build

Hints from previous work by the Cravatt lab and other groups led the team to investigate a group of molecules known as ureas for their ability to inhibit serine hydrolase activity. In initial tests using recently advanced techniques for measuring enzyme-inhibition strength and specificity, the Scripps Research scientists found that molecules known as 1,2,3-triazole ureas could powerfully inhibit some serine hydrolases without affecting other enzymes.

In the next set of tests, the team synthesized a basic "scaffold" of 1,2,3-triazole urea, and found that it inhibited many more serine hydrolases still without affecting other enzyme classes than did an existing broad inhibitor known as a carbamate. The team then began modifying the scaffold compound to refine its inhibitory activity to specific serine hydrolase target
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Jefferson scientists deliver toxic genes to effectively kill pancreatic cancer cells
2. Scientists identify novel inhibitor of human microRNA
3. Argonne scientists peer into heart of compound that may detect chemical, biological weapons
4. MU scientists go green with gold, distribute environmentally friendly nanoparticles
5. Scientists identify gene that may contribute to improved rice yield
6. Scientists discover why a mothers high-fat diet contributes to obesity in her children
7. MU scientists see how HIV matures into an infection
8. Earth scientists keep an eye on Texas
9. Thinking it through: Scientists call for policy to guide biofuels industry toward sustainability
10. Scientists identify a molecule that coordinates the movement of cells
11. Scientists Find new migratory patterns for Mediterranean and Western Atlantic bluefin tuna
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/15/2014)... and energy for nearly all life on Earth, yet ... example, little is known about how it is regulated ... we do not know the full list of the ... any organism. , , A type of single-cell green ... subject for photosynthesis research. Despite its importance in the ...
(Date:4/15/2014)... Flight Center in Greenbelt, Md., is home to ... staff. At Goddard, some of the most cutting-edge ... some of that cutting-edge innovation has earned a ... Swedish Society for Anthropology and Geography awards the ... who has shown excellence in the fields of ...
(Date:4/15/2014)... study of nearly 1,000 mother-child pairs, researchers from ... prenatal exposure to selective serotonin reuptake inhibitors (SSRIs), ... other disorders, was associated with autism spectrum disorder ... study, published in the online edition of ... ASD and DD cases, and population-based controls, where ...
Breaking Biology News(10 mins):Goddard scientist receives Vega Medal from King of Sweden 2Study: SSRI use during pregnancy associated with autism and developmental delays in boys 2
... A team of scientists from the University of Montreal ... pesticides is associated with increased risk of Attention-Deficit Hyperactivity ... journal Pediatrics , the investigation found a connection ... of ADHD. The study focused on 1,139 children from ...
... Tanganyika, the second oldest and the second-deepest lake in ... Geologists led by Brown University have determined the ... the last century, and its surface waters are the ... write in the journal Nature Geoscience , because ...
... and Human Services Secretary Kathleen Sebelius today announced one ... have been awarded to construct, repair and renovate scientific ... National Institutes of Health (NIH) National Center for Research ... create or sustain jobs nationwide and to help foster ...
Cached Biology News:Brown geologists show unprecedented warming in Lake Tanganyika 2Brown geologists show unprecedented warming in Lake Tanganyika 3HHS Secretary Sebelius announces $1 billion in NIH Recovery Act awards for research construction 2HHS Secretary Sebelius announces $1 billion in NIH Recovery Act awards for research construction 3
(Date:1/15/2014)... January 15, 2014 This webinar ... on nonclinical and clinical safety assessment in biosimilars. ... guide a path for biosimilar drug development, however ... of biosimilarity with regards to quality, safety and ... of biosimilar drug development and registration, development strategies ...
(Date:1/15/2014)... NC (PRWEB) January 15, 2014 ... an enhancement to its Online Web Portal for Life ... now have the ability to specify the subject matter ... nearly 50 life science sub-domains. This will help reduce ... and scientific fields, and decrease the likelihood of error. ...
(Date:1/14/2014)... Doylestown, PA (PRWEB) January 14, 2014 ... – 11 p.m. , Location: Warrington Country Club, 1360 ... Hepatitis B Foundation, the only national nonprofit organization solely ... improving the quality of life for those affected worldwide, ... 11 at Warrington Country Club in Warrington, Pa. ...
(Date:1/14/2014)... York, NY (PRWEB) January 14, 2014 ... initiated coverage of Alliqua, Inc. (OTCQB: ALQA). Alliqua ... and marketing proprietary products to serve the wound ... , In late 2012, Alliqua was restructured ... launched the company’s new strategy to become a ...
Breaking Biology Technology:Xtalks Life Sciences Webinar Examines Safety Assessment of Biosimilars 2DTS Improves Efficiency for Life Science Document Translations 2Hepatitis B Foundation to Host Annual Crystal Ball Gala 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 3
... ... Business, SEATTLE, April ... that Craig W. Philips, most recently,Vice President and General Manager of ... for all Development and,Commercial Operations, effective August 1, 2008. Philips, responsibilities,will ...
... Duke University chemists have found a way to grow ... very large numbers, removing a major roadblock in ... carbon nanotubes also follow parallel paths as they grow ... electronic performance, said Duke associate chemistry professor Jie Liu, ...
... PHILADELPHIA, April 23 eResearchTechnology,Inc. (eRT), (Nasdaq: ... collection and interpretation services,announced today that it will ... ended March 31, 2008 on Monday, May 5,2008 ... will host a conference call at 5:00 PM ...
Cached Biology Technology:Veteran Drug Industry Executive to Become President of CTI 2Veteran Drug Industry Executive to Become President of CTI 3Veteran Drug Industry Executive to Become President of CTI 4Nanotubes grown straight in large numbers 2Nanotubes grown straight in large numbers 3eResearchTechnology, Inc. to Announce 2008 First Quarter Results on May 5, 2008 2
... 1;heading 2;Many mammalian ... experimental situations create ... transfection and other ... ViraPower Lentiviral Expression ...
... Product Rabbit polyclonal to ... conjugated to KLH, corresponding to amino ... / Specificity Cross-reacts with Rat.Expected to ... Mouse (100% identity with immunogen), Rabbit (100% ...
RayBio Human Angiogenesis Antibody Array 2.1 (8 array membranes) with Accessory, detects 23 angiogenic factors (for lysate) Class: Antibody Array Products Product Group: Antibody Array...
... Cryo/CryoPlus Inventory Racks for ... available with cardboard or stainless ... or 5ml cryo vials. ... racks available. Platform risers ...
Biology Products: