Navigation Links
Scientists find new class of compounds with great potential for research and drug development
Date:5/15/2011

Scientists from The Scripps Research Institute have identified a class of compounds that could be a boon to basic research and drug discovery.

In a new study, published online in Nature Chemical Biology on May 15, 2011, the researchers show the new compounds powerfully and selectively block the activity of a large and diverse group of enzymes known as "serine hydrolases." Previously discovered serine hydrolase-blocking compounds have been turned into drugs to treat obesity, diabetes, and Alzheimer's disease, and are currently in testing as treatments for pain, anxiety, and depression.

"There are more than 200 serine hydrolases in human cells, but for most we've lacked chemical inhibitors of their activity," said team leader Benjamin F. Cravatt III, professor and chair of the Department of Chemical Physiology at Scripps Research and a member of its Skaggs Institute for Chemical Biology, "so we've had only a limited ability to study them in the lab or to block them to treat medical conditions. This new research allows us to greatly expand our list of these inhibitors."

A Scaffold on Which to Build

Hints from previous work by the Cravatt lab and other groups led the team to investigate a group of molecules known as ureas for their ability to inhibit serine hydrolase activity. In initial tests using recently advanced techniques for measuring enzyme-inhibition strength and specificity, the Scripps Research scientists found that molecules known as 1,2,3-triazole ureas could powerfully inhibit some serine hydrolases without affecting other enzymes.

In the next set of tests, the team synthesized a basic "scaffold" of 1,2,3-triazole urea, and found that it inhibited many more serine hydrolases still without affecting other enzyme classes than did an existing broad inhibitor known as a carbamate. The team then began modifying the scaffold compound to refine its inhibitory activity to specific serine hydrolase target
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Jefferson scientists deliver toxic genes to effectively kill pancreatic cancer cells
2. Scientists identify novel inhibitor of human microRNA
3. Argonne scientists peer into heart of compound that may detect chemical, biological weapons
4. MU scientists go green with gold, distribute environmentally friendly nanoparticles
5. Scientists identify gene that may contribute to improved rice yield
6. Scientists discover why a mothers high-fat diet contributes to obesity in her children
7. MU scientists see how HIV matures into an infection
8. Earth scientists keep an eye on Texas
9. Thinking it through: Scientists call for policy to guide biofuels industry toward sustainability
10. Scientists identify a molecule that coordinates the movement of cells
11. Scientists Find new migratory patterns for Mediterranean and Western Atlantic bluefin tuna
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... cells to rearrange existing patterns of activity than when ... study of monkeys has found. The scientists explored the ... of brain cell networks. The study was partly funded ... into the brain and may have seen why it,s ... Batista, Ph.D., an assistant professor at the University of ...
(Date:8/27/2014)... want to listen carefully to someone, the first thing ... do is stop moving altogether. This strategy helps us ... own movements. , This interplay between movement and hearing ... indirect evidence has long suggested that the brain,s motor ... which gives rise to our conscious perception of sound. ...
(Date:8/27/2014)... in German . ... common inherited disease affecting the peripheral nervous system. Researchers ... Institute of Experimental Medicine and University Medical Centre Gttingen ... impaired in rats with the disease. These cells enwrap ... myelin, which facilitates the rapid transfer of electrical impulses. ...
Breaking Biology News(10 mins):Scientists plug into a learning brain 2Scientists plug into a learning brain 3Stop and listen: Study shows how movement affects hearing 2Stop and listen: Study shows how movement affects hearing 3Potential therapy for incurable Charcot-Marie-Tooth disease 2
... that prevents the body from using stored sugar has survived ... at the University of Florida putting scientists a step ... Called glycogen storage disease type 1A, the genetic disease ... use sugar between meals. In order to survive, children and ...
... Francisco, and collaborators at Harvard Medical School have linked ... that clears glucose out of the bloodstream, shedding light ... a cellular level. Establishing the function ... mice, has broad implications for both the future study ...
... for Cancer Research at the University of California, San ... of the contractile ring, a structure required for cell ... divide the cell may facilitate development of therapies to ... researchers show that even though both cell volume ...
Cached Biology News:UF makes gene therapy advance in severe genetic disorder 2UF makes gene therapy advance in severe genetic disorder 3UCSF discovers new glucose-regulating protein linked with diabetes 2Study may aid efforts to prevent uncontrolled cell division in cancer 2
(Date:8/27/2014)... Aug. 27, 2014 Reportbuyer.com has added ... Graphene Opportunity - A Rational View ... New Nanotech? A similar amount of hype ... ranging from microelectronics to water treatment, but is ... availability of the Graphene Opportunity Report, authored by ...
(Date:8/27/2014)... , Aug. 27, 2014  ARCH Venture Partners, ... investing in the development of seed and early-stage ... venture fund closed with more than $400 million ... $250 million subscription target by more than $150 ... shows the strength and potential of our approach ...
(Date:8/27/2014)... White City, OR (PRWEB) August 27, 2014 ... it stands to reason that the next beverage craze ... Force Technology announced today that formulators can use Stress ... any ingredient used in the making of a beverage, ... natural release for stress-generated energy, channeling that power into ...
(Date:8/27/2014)... Budding Biomedical Scientists , This ... participated in the Scientific Enrichment and Opportunity ... of Medicine . , The rigorous ... experience in the sciences and brings them in ... students for both academic and career mentoring. , ...
Breaking Biology Technology:The Graphene Opportunity - A Rational View 2The Graphene Opportunity - A Rational View 3The Graphene Opportunity - A Rational View 4Latest ARCH Venture Partners Fund Closes Above $400 Million 2Latest ARCH Venture Partners Fund Closes Above $400 Million 3Stress Relief: 1 Way to De-Stress Your Beverage Formula 2Stress Relief: 1 Way to De-Stress Your Beverage Formula 3Stress Relief: 1 Way to De-Stress Your Beverage Formula 4Students at Cleveland's University School Conduct Biomedical Research at Case Western Reserve University’s School of Medicine 2
... , NEW YORK, Sept. 8 Reportlinker.com announces that a ... Nanomedicine , , ... This report analyzes the Global Market for Nanomedicine in Millions of US$ ... Imaging, Biomaterials, and Others. Annual forecasts are provided for the period of ...
... , ATLANTA and BRIDGEWATER, N.J. Sept. 8 From ... this year,s back to school they should also prepare for the upcoming ... new school year, the My Xperts(TM) program, created by UCB and sanofi-aventis ... outdoor nasal allergy experts to help parents prepare for fall allergy season ...
... ... , ... September 8, 2009 -- Ensuring food security for a growing world population is a ... that involves novel approaches and techniques to meet future demands, William S. Niebur ...
Cached Biology Technology:Reportlinker Adds Nanomedicine Report 2Reportlinker Adds Nanomedicine Report 3Reportlinker Adds Nanomedicine Report 4Reportlinker Adds Nanomedicine Report 5Reportlinker Adds Nanomedicine Report 6Reportlinker Adds Nanomedicine Report 7Reportlinker Adds Nanomedicine Report 8Reportlinker Adds Nanomedicine Report 9Reportlinker Adds Nanomedicine Report 10Reportlinker Adds Nanomedicine Report 11VIDEO: Nasal Allergy Experts Offer Free Advice for Back to School Sneezin' 2VIDEO: Nasal Allergy Experts Offer Free Advice for Back to School Sneezin' 3VIDEO: Nasal Allergy Experts Offer Free Advice for Back to School Sneezin' 4VIDEO: Nasal Allergy Experts Offer Free Advice for Back to School Sneezin' 5VIDEO: Nasal Allergy Experts Offer Free Advice for Back to School Sneezin' 6DuPont Leader Says Increasing Food Production a Moral Imperative 2DuPont Leader Says Increasing Food Production a Moral Imperative 3
... Best: DASGIPs Process Control integrates Process ... comprehensive documentation for cultivation processes. A ... pH, dissolved oxygen, temperature and agitation ... Profiles, e.g. constant or scheduled media ...
... LC Sciences provides a genome-wide microRNA ... and proprietary probe design, which enable highly ... (1-3). We have standard arrays for mature ... latest version of the Sanger miRBase database ...
... synthetic peptide whose sequences are derived from mouse resistin protein. ... - S - M - P - L - C - ... - D - K - K - I - K - ... used for neutralization and control experiments with the polyclonal antibody that ...
... Imaging System, Basic Package Superior Protein ... Range: The ProXPRESS 2D Proteomic Imaging System ... for both proteomic and general life science ... enabling the use of all dyes in ...
Biology Products: