Navigation Links
Scientists find gene for high cholesterol in blood
Date:9/15/2010

Scientists at the Southwest Foundation for Biomedical Research (SFBR) in San Antonio have found a gene that causes high levels of bad cholesterol to accumulate in the blood as a result of a high-cholesterol diet.

Researchers studied a strain of laboratory opossums developed at SFBR that has normal blood levels of "bad" low-density lipoprotein (LDL) cholesterol when fed a standard low-cholesterol diet, but extremely elevated levels of LDL cholesterol when fed a high-cholesterol diet. These high-responding opossums are used to identify the genes and the underlying mechanisms that control response to dietary cholesterol.

"This research will improve our understanding of cholesterol metabolism and may shed light on why some people have high levels of bad cholesterol in blood while others do not when they consume cholesterol-enriched diets," said John L. VandeBerg, Ph.D., SFBR's chief scientific officer and senior author on the paper. Published in the October issue of the Journal of Lipid Research, the work was funded by the National Institutes of Health and the Robert J. Kleberg, Jr. and Helen C. Kleberg Foundation.

The study involved analyzing various lipids, or fats, in blood and bile to find differences in cholesterol metabolites, sequencing candidate genes of interest to find mutations, and determining the impact of each mutation by genetic analyses. This led to the discovery that the ABCB4 gene, which encodes a protein known to transport fats from the liver into bile to facilitate excretion of cholesterol from the body, is defective in the high responders. Malfunction of the ABCB4 protein was found to impair cholesterol excretion, causing bad cholesterol to accumulate in the blood when a high-cholesterol diet is consumed.

"This is the first report to show that ABCB4 has a role in controlling blood cholesterol levels in response to dietary cholesterol in an animal model," said VandeBerg.

The next step is to determine if any
'/>"/>

Contact: Joseph Carey
jcarey@sfbr.org
210-258-9437
Southwest Foundation for Biomedical Research
Source:Eurekalert

Page: 1 2

Related biology news :

1. Jefferson scientists deliver toxic genes to effectively kill pancreatic cancer cells
2. Scientists identify novel inhibitor of human microRNA
3. Argonne scientists peer into heart of compound that may detect chemical, biological weapons
4. MU scientists go green with gold, distribute environmentally friendly nanoparticles
5. Scientists identify gene that may contribute to improved rice yield
6. Scientists discover why a mothers high-fat diet contributes to obesity in her children
7. MU scientists see how HIV matures into an infection
8. Earth scientists keep an eye on Texas
9. Thinking it through: Scientists call for policy to guide biofuels industry toward sustainability
10. Scientists identify a molecule that coordinates the movement of cells
11. Scientists Find new migratory patterns for Mediterranean and Western Atlantic bluefin tuna
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/1/2014)... Finland , October 1, 2014 ... through in the life science field  ... technologies come and go over the years. Some ... standard. Photon upconversion is a novel detection technology ... recent years. Now, finally, this technology is becoming ...
(Date:9/30/2014)... Millions of tourists visit the Mediterranean each year, ... currently underway on Earth. Almost 1,000 alien species, ... from other seas through human activities. In the ... a multinational team of researchers analyzed data from ... Commission to show how the introduction of alien ...
(Date:9/30/2014)... California, San Diego, have completed the first comprehensive numerical ... uses the pixels in an image as data points ... , The researchers, led by J.S. Chen, the William ... of Engineering at UC San Diego, presented their findings ... conference in Pittsburgh this month. Chen also gave a ...
Breaking Biology News(10 mins):First-of-a-kind Solution for Utilizing Photon Upconversion 2Biodiversity in the Mediterranean is threatened by alien species 2First comprehensive meshfree numerical simulation of skeletal muscle tissue achieved 2
... study shows that human milk oligosaccharides, or HMO, produce short-chain ... infant gut. Not only that, the bacterial composition adjusts as ... though HMO are a major component of human milk, present ... the infant are not well understood. Furthermore, they,re virtually absent ...
... JOLLA, CA ---- Scientists at the Salk Institute for ... of plant proteins that play a role in the ... human nutrition, biorenewable chemicals and biofuels. Scoring a ... related proteins in thale cress plants ( Arabidopsis thaliana ...
... thanks to a paper-thin generator embedded in the sole ... little closer to reality. Scientists from the U.S. Department ... developed a way to generate power using harmless viruses ... tested their approach by creating a generator that produces ...
Cached Biology News:Study sheds new light on importance of human breast milk ingredient 2Discovery of plant proteins may boost agricultural yields and biofuel production 2Discovery of plant proteins may boost agricultural yields and biofuel production 3Berkeley Lab scientists generate electricity from viruses 2Berkeley Lab scientists generate electricity from viruses 3
(Date:10/1/2014)... 30, 2014 In response to ... to address sales, training and consumer engagement challenges, ... innovative mobile applications to turn their clients’ visions ... latest customized mobile app creations, are now featured ... In partnership with Toyota, StudioPMG created a robust ...
(Date:10/1/2014)... (PRWEB) October 01, 2014 The U.S. ... to Southern Illinois University Edwardsville as part of the ... initiative. The funding is co-administered by the Department of ... Biden, Secretary of Labor Thomas E. Perez and Secretary ... million in job-driven training grants to nearly 270 colleges ...
(Date:9/30/2014)... German . ... have demonstrated a new kind of building block for ... chips could be based on three-dimensional arrangements of nanometer-scale ... of the semiconductor industry CMOS fabrication of silicon ... collaborators at the University of Notre Dame are exploring ...
(Date:9/30/2014)... Sept. 30, 2014 Nematicide is a ... Nematodes are microscopic parasitic roundworms, found in massive ... other plants and animals. Nematicides have tended to ... properties promoting migration through the soil. A single ... plant-parasitic nematodes. With more than 10,000 species classified, ...
Breaking Biology Technology:Digital Agency Studio PMG Launches New Case Studies on Website 2U.S. Dept. of Labor Awards SIUE Nearly $10-Million Grant 2U.S. Dept. of Labor Awards SIUE Nearly $10-Million Grant 3U.S. Dept. of Labor Awards SIUE Nearly $10-Million Grant 4A new dimension for integrated circuits: 3-D nanomagnetic logic 2A new dimension for integrated circuits: 3-D nanomagnetic logic 3Nematicides Market by Types (Fumigants, Organophosphates, Carbamate and Bio-Nematicides), Applications (Agrochemicals, Industrial, and Others), and Geography (North America, Europe, Asia-Pacific & ROW) - Global Trends & Forecasts to 2019 2
... conference at Grainger Hall. Madison, Wis. ... Wisconsin, according to the Coalition for Capital Growth and Research, ... Hall. , ,We believe [venture capital] is a worthwhile agenda ... partner at Venture Investors and the conferences founder. ...
... a look at how the large cap Midwest life science companies ... stock market. The results looked very positive for at least 75 ... market growth. , ,On the negative side, some of the poor ... our largest Big Pharma companies (namely Abbott Labs and Eli Lilly). ...
... I never cease to be amazed by the games that ... to goose up revenues and shore up profits. Most of ... Lately, things have gotten ridiculous enough to make one yearn ... calls. , ,And Im not talking about the nuisance of ...
Cached Biology Technology:Wisconsin investors seek regional partners and informed legislature 2Wisconsin investors seek regional partners and informed legislature 3Midwest small-cap life sciences turn in mixed third-quarter results 2Show customers leadership, not gamesmanship 2Show customers leadership, not gamesmanship 3
... The FastPlax Antibody is used to ... on the surface of infected cells as ... the basis of the FastPlax Titer Kit, ... just 25-48 hours. The FastPlax ...
Anti-Mouse Ly 6C.2 , Ascites (Clone 5075-3.6) (mouse IgG2b)...
b-Catenin (pSer675), phospho-specific...
Goat polyclonal to SIAH Interacting Protein ( Abpromise for all tested applications)....
Biology Products: