Navigation Links
Scientists find ethnicity linked to antibodies
Date:4/18/2013

Cracking the DNA code for a complex region of the human genome has helped 14 North American scientists, including five at Simon Fraser University, chart new territory in immunity research.

They have discovered that a good number of our antibody genes, how well they operate and, potentially, what they fight off, actually vary from person to person. That means even though drugs, treatments and vaccinations are designed to treat whole populations our response to them could be individualistic.

After completely sequencing the immensely repetitive DNA in the human genome's one million nucleotide-long immunoglobulin heavy (IGH)-chain locus, these scientists have also found ethnicity influences immunity.

"Time will confirm the extent to which this is true. But we've found that sections of the IGH-chain locus' DNA sequence are either missing or inserted into a person's genome, and this could vary depending on ethnicity," explains Corey Watson.

A postdoctoral researcher at the Mount Sinai School of Medicine in New York, Watson completed his doctoral studies under the supervision of SFU biologist Felix Breden who leads this research project. Watson and Breden still collaborate on research.

Scientists have long known that our IGH-chain locus is our most prolific producer of the 50-plus varied and diverse antibody-encoding genes that our B cells use to fight off infections and diseases.

But thanks to new data-mining technology, this is the first study to radically refine and, until now, roughly-piecemealed genomic map of the human IGH-chain locus.

"Because this is the most complete version of a human's IGH sequence," says Watson, "our data has been integrated into the official human genome project assembly."

Using a single chromosome of an individual, the latest study sequences all possible antibody-encoding genes in our IGH-chain locus. It also identifies 11 possible large DNA insertions and deletions of antibody-encoding genes in the region that determine our antibody gene count/diversity and, in some cases, have been implicated in disease susceptibility.

The scientists uncovered the link between antibody makeup and ethnicity when they screened the chromosomes of 425 people of Asian, African and European descent for several DNA insertions and deletions.

"Again, it's early days," emphasizes Watson, "but these findings could mean that past environmental exposures to certain pathogens caused DNA insertions or deletions in different ethnic groups, which could impact disease risk. Our results demonstrate that antibody studies need to take into account the ethnicity of DNA samples used."

This study's findings will advance research on how IGH-related antibody genetic variation between individuals impacts our ability to fight viruses such as the flu and HIV.

Watson, Breden, three other SFU scientists (Jamie Scott, Jeffery Joy and Robert Holt), science alumnus Jeremy Willsey and researchers in the United States and at the B.C. Cancer Agency contributed equally to this study.

Evan Eichler, a scientist at Seattle's University of Washington genome sciences department and Howard Hughes Medical Institute, developed the technology making this study possible.

The American Journal of Human Genetics (Cell Press) published its findings in the article Complete Haplotype Sequence of the Human Immunoglobulin Heavy-Chain Variable, Diversity and Joining Genes and Characterization of the Allelic and Copy-Number Variation, in its March 28 issue.


'/>"/>

Contact: Carol Thorbes
cthorbes@sfu.ca
778-782-3035
Simon Fraser University
Source:Eurekalert

Related biology news :

1. University of Southern California scientists reveal natural process that blocks viruses
2. Scientists look to ancient past to better predict how species may respond climate change
3. Scientists learn what makes nerve cells so strong
4. Inter-American Network of Science Academies celebrates women scientists -- April 17 event
5. A novel surface marker helps scientists fish out mammary gland stem cells
6. Scientists stress need for national marine biodiversity observation network
7. Scientists decode genome of painted turtle, revealing clues to extraordinary adaptations
8. 8 M € from EU to enhance access by scientists to the largest European biobanks
9. CSHL neuroscientists show jumping genes may contribute to aging-related brain defects
10. NYSCF scientists develop new protocol to ready induced pluripotent stem cell clinical application
11. Scientists find government justification of new environmental policy unfounded
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/28/2016)... 28, 2016 "The biometric ... 16.79%" The biometric system market is in the ... the near future. The biometric system market is expected ... at a CAGR of 16.79% between 2016 and 2022. ... biometric technology in smartphones, rising use of biometric technology ...
(Date:11/19/2016)... Securus Technologies, a leading provider of civil ... corrections and monitoring, announced today that it has offered ... an independent technology judge determine who has the largest ... telephone calling platform, and the best customer service. ... of what we do – which clearly is not ...
(Date:11/15/2016)... Research and Markets has announced the addition of the ... their offering. ... The global bioinformatics market ... 6.21 Billion in 2016, growing at a CAGR of 21.1% during ... is driven by the growing demand for nucleic acid and protein ...
Breaking Biology News(10 mins):
(Date:12/5/2016)... CHICAGO , December 5, 2016 ... report, "Cell Expansion Market, by Products (Consumable, Instruments, ... Applications (Regenerative Medicine and Stem Cell Research, Cancer, ... Research Institutes, Cell Banks) - Global Revenue, Trends, ... by Scalar Market Research, the global cell expansion ...
(Date:12/5/2016)... , Dec 5, 2016 Research ... report "DNA Sequencing - Technologies, Markets and Companies" ... ... report briefly reviews basics of human genome variations, development of ... are described as well as companies developing them. Various applications ...
(Date:12/4/2016)... and CAMBRIDGE, Mass. and ... Dec. 4, 2016 SystemOne, a company ... software platforms for the developing world, and Daktari ... a reality with its portable and ultrasensitive immunoassay-based ... a development and license agreement to integrate Daktari,s ...
(Date:12/2/2016)... -- CytRx Corporation (NASDAQ: CYTR ), a ... announced the appointment of Earl Warren Brien , ... healthcare investor, to its Board of Directors. ... strategic experience at the highest level," said Steven ... of the world,s leading orthopedic surgeons, Dr. Brien has ...
Breaking Biology Technology: