Navigation Links
Scientists find ethnicity linked to antibodies
Date:4/18/2013

Cracking the DNA code for a complex region of the human genome has helped 14 North American scientists, including five at Simon Fraser University, chart new territory in immunity research.

They have discovered that a good number of our antibody genes, how well they operate and, potentially, what they fight off, actually vary from person to person. That means even though drugs, treatments and vaccinations are designed to treat whole populations our response to them could be individualistic.

After completely sequencing the immensely repetitive DNA in the human genome's one million nucleotide-long immunoglobulin heavy (IGH)-chain locus, these scientists have also found ethnicity influences immunity.

"Time will confirm the extent to which this is true. But we've found that sections of the IGH-chain locus' DNA sequence are either missing or inserted into a person's genome, and this could vary depending on ethnicity," explains Corey Watson.

A postdoctoral researcher at the Mount Sinai School of Medicine in New York, Watson completed his doctoral studies under the supervision of SFU biologist Felix Breden who leads this research project. Watson and Breden still collaborate on research.

Scientists have long known that our IGH-chain locus is our most prolific producer of the 50-plus varied and diverse antibody-encoding genes that our B cells use to fight off infections and diseases.

But thanks to new data-mining technology, this is the first study to radically refine and, until now, roughly-piecemealed genomic map of the human IGH-chain locus.

"Because this is the most complete version of a human's IGH sequence," says Watson, "our data has been integrated into the official human genome project assembly."

Using a single chromosome of an individual, the latest study sequences all possible antibody-encoding genes in our IGH-chain locus. It also identifies 11 possible large DNA insertions and deletions of antibo
'/>"/>

Contact: Carol Thorbes
cthorbes@sfu.ca
778-782-3035
Simon Fraser University
Source:Eurekalert

Page: 1 2

Related biology news :

1. University of Southern California scientists reveal natural process that blocks viruses
2. Scientists look to ancient past to better predict how species may respond climate change
3. Scientists learn what makes nerve cells so strong
4. Inter-American Network of Science Academies celebrates women scientists -- April 17 event
5. A novel surface marker helps scientists fish out mammary gland stem cells
6. Scientists stress need for national marine biodiversity observation network
7. Scientists decode genome of painted turtle, revealing clues to extraordinary adaptations
8. 8 M € from EU to enhance access by scientists to the largest European biobanks
9. CSHL neuroscientists show jumping genes may contribute to aging-related brain defects
10. NYSCF scientists develop new protocol to ready induced pluripotent stem cell clinical application
11. Scientists find government justification of new environmental policy unfounded
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/22/2014)... Dec. 22, 2014  The 2014 Holiday Season ... industry as Acuity Market Intelligence reports that the ... be open. Acuity forecasts that intensifying demand for ... incorporate biometrics will drive a global market of ... devices by 2020.   According to ...
(Date:12/19/2014)... 18, 2014 Research and Markets ( ... "Micro Market Monitor: North America Perimeter Security Systems Market" ... http://photos.prnewswire.com/prnh/20130307/600769 The North American perimeter ... of 3.6% from 2014 to 2019. Although the U.S. ... Canada is expected to grow at ...
(Date:12/19/2014)... 18, 2014   LaunchKey , the first decentralized ... and Internet of Things era, today announced the close ... round was led by Metamorphic Ventures with participation from ... VegasTechFund, and others.  LaunchKey has raised $4 million to ... its team and bring LaunchKey to market in 2015. ...
Breaking Biology News(10 mins):First Season of Holiday Shopping with Mobile Biometric Payments Wraps Up With a Present for Biometrics Industry: A Rosy Forecast for More Than 2 Billion Users of 4.8 Billion Mobile Biometric Devices by 2020 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 3LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 2LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 3
... Scientists have uncovered the flu,s secret formula for effectively ... lies with the flu,s unique replication process, which has ... spread and adapt to its host environment, but not ... flu,s demise (catastrophic mutagenesis). These findings overturn long-held assumptions ...
... materials to bring forth the best properties of both ... the Bronze Age. In the latest successful merger, researchers ... the University of Maryland (UM) and the U.S. Food ... combine two substances that individually have generated interest for ...
... June 9 -- CoLucid Pharmaceuticals, Inc., ("CoLucid"), ... central nervous system disorders, today announced that its ... (also known as COL-144), a selective 5-HT1F receptor ... acute migraine attacks, as documented in a Phase ...
Cached Biology News:Flu's evolution strategy strikes perfect balance 2Flu's evolution strategy strikes perfect balance 3Liposome-hydrogel hybrids: No toil, no trouble for stronger bubbles 2CoLucid Pharmaceuticals, Inc. announces study data documenting oral efficacy of lasmiditan (COL-144), a selective 5-HT1F receptor agonist, in the treatment of acute migraine attacks 2
(Date:12/19/2014)... The empty capsules market is experiencing ... and technological innovations in the empty capsules market. ... the growth of the empty capsules market. , ... Scope of Report , The report will enrich ... firms to gauge the pulse of the market ...
(Date:12/19/2014)... Dec. 18, 2014   ISN has released ... Performance Indicators publication series. With data aggregated ... reported in 2013 within its online contractor management platform, ... key performance indicator (KPI) statistics. The ... publication is available in two industry specific ...
(Date:12/17/2014)... December 16, 2014 “Never say, ... Philipps- Universität Marburg’s Department of Physics, advises young ... the newly released SPIE Women in Optics ... too shy to ask questions.” , In the ... and mathematics) occupations ranging from university professor and ...
(Date:12/17/2014)... Texas (PRWEB) December 17, 2014 ... on Global Quartz Tubing industry. For an overview ... definition, classification, application, industry chain structure, industry overview, ... quartz tubing industry has witnessed rapid ... a number of acquisitions. This report mentions quartz ...
Breaking Biology Technology:Empty Capsules Market Hit to Reach $1,820 Million by 2019 - New Research Report by MarketsandMarkets 2Empty Capsules Market Hit to Reach $1,820 Million by 2019 - New Research Report by MarketsandMarkets 3Empty Capsules Market Hit to Reach $1,820 Million by 2019 - New Research Report by MarketsandMarkets 4ISN Releases Third Edition of US Contractor Health & Safety Performance Indicators Publication Series 2ISN Releases Third Edition of US Contractor Health & Safety Performance Indicators Publication Series 3Network, Multitask, Persevere: SPIE Women in Optics Planner Subjects Share from Experience 2Network, Multitask, Persevere: SPIE Women in Optics Planner Subjects Share from Experience 32020 Quartz Tubing Market: Global Development & Forecasts Analysis Now at DeepResearchReports.com 2
... our mobile phone to buy bus and train tickets and ... by just presenting an electronic card or passport, thanks to ... us hate standing in queues or filling out forms, however ... hours of our time running to offices and waiting for ...
... NEW YORK , June 25 ... or the "Company"), an international biopharmaceutical,company with operations in the ... entered into definitive agreements with certain accredited,investors (the "Investors") to ... gross offering price of $5 million . Each unit ...
... , June 25 Caliper Life Sciences, Inc. (Nasdaq: ... drug discovery and life sciences research, hosted its 2010 annual Customers ... 10. This thought-leadership conference is focused on sharing knowledge, insights, and ... the next generation of breakthrough diagnostics and therapies. , ...
Cached Biology Technology:Really smart card project scoops EUREKA 2010 Innovation Award 2Really smart card project scoops EUREKA 2010 Innovation Award 3Really smart card project scoops EUREKA 2010 Innovation Award 4NeoStem Raises $5 Million in Registered Direct Offering 2NeoStem Raises $5 Million in Registered Direct Offering 3NeoStem Raises $5 Million in Registered Direct Offering 4Caliper Owners Group Meeting Showcases Critical Role of Biopharma and Academic Researchers for Improving Healthcare and Quality of Life 2Caliper Owners Group Meeting Showcases Critical Role of Biopharma and Academic Researchers for Improving Healthcare and Quality of Life 3
... provides both long and short-term enriched housing ... in both quarantine and non-quarantine settings on ... also available utilizing our state-of-the-art social housing ... equipped with on site CDC quarantine facilities. ...
... This exceptionally sensitive nucleic acid gel stain ... low background in gels, making it ideal for ... standard UV transilluminators. SYBR Green I nucleic ... capillary electrophoresis, real-time PCR assays and bandshift ...
Synonym: modified Grace's Insect medium...
Schneider's Drosophila - Insect medium...
Biology Products: