Navigation Links
Scientists find differences in naked mole rat's protein disposers
Date:5/11/2012

SAN ANTONIO (May 11, 2012) The naked mole rat, a curiously strange, hairless rodent, lives many years longer than any other mouse or rat. Scientists at The University of Texas Health Science Center San Antonio's Barshop Institute of Longevity and Aging Studies continue to explore this mystery.

On May 2 a Barshop Institute team reported that the naked mole rat's cellular machines for protein disposal called proteasome assemblies differ in composition from those of other short-lived rodents. The study is in the journal PLoS ONE.

This is the first report of the molecular mechanisms that underlie the naked mole-rat's superior ability to maintain protein integrity. "More effective removal of damaged proteins within the cell would enable the animal to be able to maintain good function and is likely to contribute to its excellent maintenance of good health well into its third decade of life," said Rochelle Buffenstein, Ph.D., of the Barshop Institute. Dr. Buffenstein is a professor of physiology and cellular and structural biology in the School of Medicine at the UT Health Science Center.

Protein integrity

Dr. Buffenstein and her research team in 2009 reported that the naked mole-rat maintains exceptional protein integrity throughout its long and healthy life. In the new study, the team found a greater number of proteasomes and higher protein-disposal activity in naked mole-rat liver cells.

The Barshop Institute scientists, including lead author Karl Rodriguez, Ph.D., postdoctoral fellow, and Yael Edrey, graduate student, also found large numbers of immunoproteasomes in the liver cells a bit of a surprise because these protein disposers, which remove antigens after presentation in the immune system, are more commonly found in the spleen and thymus.

"Given the high levels of oxidative damage routinely seen in liver tissue of naked mole-rats, it is likely that, in the liver, these immunoprotea
'/>"/>

Contact: Will Sansom
sansom@uthscsa.edu
210-567-2579
University of Texas Health Science Center at San Antonio
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Scripps Florida scientists identify neurotranmitters that lead to forgetting
2. Scientists discover new inflammatory target
3. EMBO welcomes 55 leading life scientists as members
4. UCLA life scientists unlock mystery of how handedness arises
5. Computer scientists develop an interactive field guide app for birders
6. Scientists discover new type of cell with a key role in treatment-resistant asthma
7. Insect scientists to meet in Lincoln, Neb., in June
8. Scientists identify prostate cancer stem cells among low-PSA cells
9. Scientists core into Californias Clear Lake to explore past climate change
10. Scientists make stunning inner space observations
11. Scientists discover enzyme that could slow part of the aging process in astronauts -- and the elderly
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists find differences in naked mole rat's protein disposers
(Date:5/25/2015)... , May 25, 2015  Australia,s market for ... stage, although 2014 saw the advent of several trials ... 24 April 2015 is expected to ignite interest in ... in Australia . This in turn ... industry and drive new partnerships amongst vendors and distributors. ...
(Date:5/21/2015)... 2015 The Sync Project™ , a ... health, today announced a collaborative partnership with Berklee,s ... center on collaboration on original research, joint course development ... the collaboration, The Sync Project and BerkleeICE are exploring ... in the 2015-2016 academic year.  The ...
(Date:5/19/2015)... May 19, 2015  Technology is rapidly advancing, outpacing ... in the cloud. Passwords and their management are soon ... and standards-based specifications such as those developed by the ... of passwords presents for BYOD, COPE, IoT, and mobile ... identity protocol. In response to the ...
Breaking Biology News(10 mins):Australian wearables market to grow at CAGR of 78%; revenue of A$1 billion by 2018, says Frost & Sullivan 2Australian wearables market to grow at CAGR of 78%; revenue of A$1 billion by 2018, says Frost & Sullivan 3Australian wearables market to grow at CAGR of 78%; revenue of A$1 billion by 2018, says Frost & Sullivan 4The Sync Project Announces Partnership with Berklee College of Music's Institute for Creative Entrepreneurship 2The Sync Project Announces Partnership with Berklee College of Music's Institute for Creative Entrepreneurship 3HYPR Corp. Biometric Security Integration Kit Shields Applications and Devices Across the Internet of Things 2HYPR Corp. Biometric Security Integration Kit Shields Applications and Devices Across the Internet of Things 3
... and involvement in meaningful activitiesgoing beyond just diet and ... USC study. Guided by lifestyle advisors, seniors participating ... routines (such as visiting a museum with a friend ... quality of life, including lower rates of depression and ...
... Dr. Glen Weiss, who holds joint appointments at ... Virginia G. Piper Cancer Center at Scottsdale Healthcare, is ... cancer research consortium. In this new position, Dr. ... (CRAB-CTC), a Seattle-based cooperative research network, created by a ...
... work published in the June 2011 issue of ... co-investigators - a multidisciplinary team within the Institute for ... transferred the concept of redox-sensitive Green Fluorescent Proteins (GFPs) ... platform. For the FRET-based sensors, a change in redox ...
Cached Biology News:USC: Active social, spiritual and physical life helps prevent health decline in seniors 2USC: Active social, spiritual and physical life helps prevent health decline in seniors 3TGen, Virginia G. Piper Cancer Center scientist heads lung cancer consortium 2Development of a FRET sensor for real-time imaging of intracellular redox dynamics 2Development of a FRET sensor for real-time imaging of intracellular redox dynamics 3
(Date:5/29/2015)... Worth, Texas (PRWEB) May 29, 2015 Translation ... grow. This is for a good reason--if used in a ... wonders for the offering of a business product or service ... which translation can have a positive effect on a company's ... or service that anyone in the world can use, why ...
(Date:5/28/2015)... DUBLIN , May 28, 2015 ... Markets ( http://www.researchandmarkets.com/research/8h5hs2/animal ) has announced the ... "Animal Biotechnology - Technologies, Markets and ... http://photos.prnewswire.com/prnh/20130307/600769) , ,This report describes and ... in veterinary medicine and pharmaceuticals as ...
(Date:5/28/2015)... -- Research and Markets( http://www.researchandmarkets.com/research/3nl6s2/neuroprotection ) has announced ... "Neuroprotection - Drugs, Markets and Companies" to ... role of neuroprotection in acute disorders such as ... well as in chronic diseases such as neurodegenerative ... damage to neural tissues are similar in all ...
(Date:5/28/2015)... May 28, 2015 DryLet, LLC ... in applications such as animal waste reduction, bioremediation, ... reduction in wastewater treatment plants and restaurant kitchen ... World Pork Expo, June 3-5 in Des Moines, ... in a Wall Street Journal article because of ...
Breaking Biology Technology:Three Ways Translation Can Help Businesses Grow 2Global Animal Biotechnology Report 2015 - Technologies, Markets and Companies Analysis to 2024 2Global Animal Biotechnology Report 2015 - Technologies, Markets and Companies Analysis to 2024 3Global Neuroprotection Market Report 2015-2024 - Drugs, Markets and Companies 2Global Neuroprotection Market Report 2015-2024 - Drugs, Markets and Companies 3DryLet to Showcase Patented ManureMagicâ„¢ at the 2015 World Pork Expo, June 3-5 in Des Moines, Iowa 2
... here at Buzz-Word Central feel conditions warrant raising the threat ... increased level of chatter around the term in the IT ... this term have not been identified, Buzz-Word Central subscribers are ... going a bit too far, but the idea that technology ...
... been playing with some new toys that you might find to ... , ,You know Kensington as a purveyor of computing ... me some of their latest products to try. One of their ... with surprises. All of the products are very nicely designed, rugged ...
... Governor Jim Doyles proposal to invest nearly $750 million ... Budget-conscious members of the Legislature have choked on the ... protested, and Milwaukee politicians have asked if theyre being ... all legitimate gripes about the specifics of his plan, ...
Cached Biology Technology:Simple versus simple-minded 2Simple versus simple-minded 3Last-minute stocking stuffers 2Last-minute stocking stuffers 3Wisconsin cannot afford to take a pass on Doyles biotech plan 2Wisconsin cannot afford to take a pass on Doyles biotech plan 3
General description: MaxiSorp TM surface is ideal for arraying molecules with mixed hydrophilic/hydrophobic domains such as proteins ID clarifier: Maxisorp(tm) with lid...
... for fully automated systems for a broad ... configured for applications ranging from compound logistics, ... loop screening, which means it has fully ... picking and follow up studies all at ...
... of experience in providing versatile liquid handling ... EVO platform delivers even more flexibility and ... Together with the new easy-to-use software, Freedom ... operate genomics, proteomics, and drug discovery applications. ...
... Systems provide fast and reliable automation ... and drug development laboratories. Staccato Custom ... specifications, providing solutions that are tailored ... Custom Systems are controlled with either ...
Biology Products: