Navigation Links
Scientists find differences in naked mole rat's protein disposers
Date:5/11/2012

SAN ANTONIO (May 11, 2012) The naked mole rat, a curiously strange, hairless rodent, lives many years longer than any other mouse or rat. Scientists at The University of Texas Health Science Center San Antonio's Barshop Institute of Longevity and Aging Studies continue to explore this mystery.

On May 2 a Barshop Institute team reported that the naked mole rat's cellular machines for protein disposal called proteasome assemblies differ in composition from those of other short-lived rodents. The study is in the journal PLoS ONE.

This is the first report of the molecular mechanisms that underlie the naked mole-rat's superior ability to maintain protein integrity. "More effective removal of damaged proteins within the cell would enable the animal to be able to maintain good function and is likely to contribute to its excellent maintenance of good health well into its third decade of life," said Rochelle Buffenstein, Ph.D., of the Barshop Institute. Dr. Buffenstein is a professor of physiology and cellular and structural biology in the School of Medicine at the UT Health Science Center.

Protein integrity

Dr. Buffenstein and her research team in 2009 reported that the naked mole-rat maintains exceptional protein integrity throughout its long and healthy life. In the new study, the team found a greater number of proteasomes and higher protein-disposal activity in naked mole-rat liver cells.

The Barshop Institute scientists, including lead author Karl Rodriguez, Ph.D., postdoctoral fellow, and Yael Edrey, graduate student, also found large numbers of immunoproteasomes in the liver cells a bit of a surprise because these protein disposers, which remove antigens after presentation in the immune system, are more commonly found in the spleen and thymus.

"Given the high levels of oxidative damage routinely seen in liver tissue of naked mole-rats, it is likely that, in the liver, these immunoproteasomes may play a critical role in the processing of oxidatively damaged proteins," Dr. Buffenstein said.

Oxidative stress

Oxygen is a reactive molecule, rusting unsealed metals and darkening fruit. In the body over time, it is thought to cause an accumulation of damage leading to functional decline, diseases and aging. This is called the oxidative stress theory of aging.

Naked mole-rats, which live underground in the wild, exhibit high levels of oxidative stress even at a young age, yet do not show many signs of age-related decline until very late in life.

"The composition of proteasomes and the presence of immunoproteasomes in the liver are key pieces of the jigsaw puzzle evaluating how naked mole-rats preserve health span well into their third decade of life," Dr. Buffenstein said.


'/>"/>

Contact: Will Sansom
sansom@uthscsa.edu
210-567-2579
University of Texas Health Science Center at San Antonio
Source:Eurekalert  

Related biology news :

1. Scripps Florida scientists identify neurotranmitters that lead to forgetting
2. Scientists discover new inflammatory target
3. EMBO welcomes 55 leading life scientists as members
4. UCLA life scientists unlock mystery of how handedness arises
5. Computer scientists develop an interactive field guide app for birders
6. Scientists discover new type of cell with a key role in treatment-resistant asthma
7. Insect scientists to meet in Lincoln, Neb., in June
8. Scientists identify prostate cancer stem cells among low-PSA cells
9. Scientists core into Californias Clear Lake to explore past climate change
10. Scientists make stunning inner space observations
11. Scientists discover enzyme that could slow part of the aging process in astronauts -- and the elderly
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists find differences in naked mole rat's protein disposers
(Date:3/13/2017)... March 13, 2017 Future of security: Biometric Face Matching ... ... DERMALOGs Face Matching enables to match face pictures against each ... to identify individuals. (PRNewsFoto/Dermalog Identification Systems) ... DERMALOG,s "Face Matching" is the fastest software for biometric Face Matching on ...
(Date:3/9/2017)... and MOUNTAIN VIEW, Calif. , ... Well Made Simple," and 23andMe , the leading ... better food choices.  Zipongo can now provide customers with ... preferences, health goals and biometrics, but also genetic markers ... choices. Zipongo,s personalized food decision support platform ...
(Date:3/7/2017)... LAKE CITY , March 7, 2017   ... that help top global companies identify the best talent, ... as Chief Sales Officer (CSO) and Diana ... Kucer,s appointments round out a seasoned executive team poised to ... and beyond, building on a year of record bookings ...
Breaking Biology News(10 mins):
(Date:3/29/2017)... Washington, PA (PRWEB) , ... March 29, 2017 ... ... largest non-profit, voluntary, health organization dedicated to finding cures for inflammatory bowel diseases ... healthcare professionals, have partnered to deliver exclusive content to ReachMD learners. , ...
(Date:3/29/2017)... Inc. (NASDAQ: VRML), a bio-analytical solutions company focused ... the fourth quarter and full year ended December ... year for us with our first clinical utility ... reimbursement progress with Medicare, positive medical policy coverage ... cleared our 2 nd generation product Overa ...
(Date:3/29/2017)... YORK , March 29, 2017 "Surging ... programs deployed by the government are expected to drive ... The gesture recognition market is expected to ... a CAGR of 29.63% between 2017 and 2022. The ... 15.27 billion by 2022, growing at a CAGR of ...
(Date:3/29/2017)... March 29, 2017 WuXi Biologics, a ... dedicated to biologics and a WuXi AppTec Affiliate, ... Asia-Pacific Best Bioprocessing Excellence Award from IMAPAC, a ... Awards aims to recognize outstanding leaders and trend-setters ... top bioprocessing and biomanufacturing experts in the industry, ...
Breaking Biology Technology: