Navigation Links
Scientists find bone-marrow environment that helps produce infection-fighting T and B cells
Date:2/24/2013

DALLAS Feb. 24, 2013 The Children's Medical Center Research Institute at UT Southwestern has deepened the understanding of the environment within bone marrow that nurtures stem cells, this time identifying the biological setting for specialized blood-forming cells that produce the infection-fighting white blood cells known as T cells and B cells.

The research found that cells called early lymphoid progenitors, which are responsible for producing T cells and B cells, thrive in an environment known as an osteoblastic niche. The investigation, published online today in Nature and led by Dr. Sean Morrison, also establishes a promising approach for scientists to map the entire blood-forming system.

Scientists already know how to manufacture large quantities of stem cells that give rise to the nervous system, skin, and other tissues. But they have been unable to make blood-forming stem cells in a laboratory, in part because of a lack of understanding about the niche in which blood-forming stem cells and other progenitor cells reside in the body.

"We believe this research moves us one step closer toward the development of cell therapies in the blood-forming system that don't exist today," said Dr. Morrison, Director of the Institute and Professor of Pediatrics at UT Southwestern Medical Center. "In understanding the environments for blood-forming stem cells and those of different kinds of progenitor cells, we can work toward reproducing those environments in the lab and growing cells that can be transplanted to treat a host of medical conditions."

These findings eventually may help increase the safety and effectiveness of bone-marrow transplants, such as those needed after healthy marrow is destroy
'/>"/>

Contact: Jeff Carlton
jeffrey.carlton@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert  

0

GOOD

Page: 1 2

Related biology news :

1. Stanford scientists develop gene therapy approach to grow blood vessels in ischemic limbs
2. Queens scientists seek vaccine for Pseudomonas infection
3. Scientists produce eye structures from human blood-derived stem cells
4. American Society of Plant Biologists honors early career women scientists
5. Brandeis scientists win prestigious prize for circadian rhythms research
6. Scientists discover new method of proton transfer
7. Salk scientists open new window into how cancers override cellular growth controls
8. WileyChina.com - Now Featuring Bespoke Pages for China’s Life Scientists
9. Scientists win $2 million to study new pathway in development and maintenance of lymphoma
10. UGA scientists reveal genetic mutation depicted in van Goghs sunflower paintings
11. Genetic mutation depicted in van Goghs sunflower paintings revealed by scientists
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists find bone-marrow environment that helps produce infection-fighting T and B cells
(Date:5/22/2013)... A new, streamlined approach to genetic engineering drastically ... new genes into bacteria, the workhorses of biotechnology, ... ACS Synthetic Biology , the method paves the ... for drug development, environmental cleanup and other activities. ... or integrating, a piece of the genetic material ...
(Date:5/22/2013)... feared Legionella pneumophila bacteria is responsible for ... In order to infect us, this pathogen has developed ... go unnoticed in our cells, thus avoiding these acting ... Basque biosciences research centre, CIC bioGUNE, in which teams ... USA and the National Supercomputation Centre in Barcelona (BSC) ...
(Date:5/22/2013)... pollinating insects and wild plants have slowed in recent ... by the University of Leeds and the Naturalis Biodiversity ... reductions in the diversity of species in Britain, Belgium ... But the picture brightened markedly after 1990, with a ... hoverflies and wild plants. , Professor Bill ...
Breaking Biology News(10 mins):Mechanism discovered which aids Legionella to camouflage itself in the organism 2Encouraging signs for bee biodiversity 2Encouraging signs for bee biodiversity 3
... Lake Tanganyika has a highly diverse fauna which closely resembles ... traced the origins of the freshwater herring of the Lake ... to 50 million years ago, coincident with a major oceanic ... organisms may help to explain the origins of other species ...
... billion pairs of molecules that form the rungs of the ... the DNA they comprise transmits traits across generations in a ... sequence of letters in the code. ... is the physical manner in which DNA is spun around ...
... origins of life and culminating with the latest findings ... will report on research spanning three billion years of ... symposium takes place on Thursday, May 1, and Friday, ... is free and open to the public. The ...
Cached Biology News:Freshwater herring had salty origin 2Scientists clarify a mechanism of epigenetic inheritance 2Scientists clarify a mechanism of epigenetic inheritance 3Rockefeller University hosts 2-day evolution symposium, May 1-2, 2008 2
(Date:5/24/2013)... 2013 Bed bug cases tend to increase ... the looming higher risk of becoming the pests' next victim ... bug guideline. In the guide, the company enumerated the steps ... them while traveling. , According to My Cleaning Products, ... bed bug infestation during summer: the warm weather and the ...
(Date:5/24/2013)... The Oklahoma tornado left the state with ... of Moore, one of the heavily damaged towns, proposed a ... cnn.com. Reaching out to also be of help, My Cleaning ... to counter the looming mold problem. , The disaster ... caused 24 deaths, My Cleaning Products shared. Ten of those ...
(Date:5/23/2013)... ROCK, Colo. , May 23, 2013 ... diagnostic company focused on obtaining FDA clearance and ... , today announced the pricing of an underwritten public ... related warrants to purchase 3,500,000 shares of its common ... at a combined public offering price of $1.25 per ...
(Date:5/23/2013)... Wis. , May 23, 2013 ... researcher, developer, and marketer of over-the-counter (OTC) medicinal ... its research opinion on the company based on ... , Non-Prescription, All Natural Product to ... the Product Outperforms #1 Prescription Competitor , ...
Breaking Biology Technology:Steps for Getting Rid of Bed Bugs without Using Chemicals and Avoiding Them While Traveling Enumerated by My Cleaning Products in Its Latest Post 2Steps for Getting Rid of Bed Bugs without Using Chemicals and Avoiding Them While Traveling Enumerated by My Cleaning Products in Its Latest Post 3Mayor of Oklahoma-Tornado-Impaired Town Proposes Storm Shelter Bill, My Cleaning Products Offers Complimentary Molderizer and Safe Shield to Help Victim with Looming Mold 2Venaxis Announces Pricing of Offering of Common Stock and Warrants 2Venaxis Announces Pricing of Offering of Common Stock and Warrants 3PuraMed BioScience (PMBS) Issued Alert Based on Market Cap of $721,756 2PuraMed BioScience (PMBS) Issued Alert Based on Market Cap of $721,756 3
... , The QIAGEN QuickLyse ... preparation of up to 15 g plasmid DNA. The quality of the DNA ensures , ... and cloning. , ... include: , One-step lysis reduced ...
... Kodak Molecular Imaging Systems introduces a line of small-animal , ... level of molecular , signal localization in ... precise multi-modal coregistration of optical or radioisotopic molecular , ... , ...
... , ... of the sample, leading to changes in the gene,expression profile. ... RT-PCR and microarray analysis,it is important to stabilize the RNA ... RNA from animal tissues, bacteria, and human blood and now ...
Cached Biology Technology:QuickLyse Miniprep Kit 2Kodak in vivo imaging system: precise coregistration of molecular imaging with anatomical X-ray imaging in animals 2Kodak in vivo imaging system: precise coregistration of molecular imaging with anatomical X-ray imaging in animals 3Kodak in vivo imaging system: precise coregistration of molecular imaging with anatomical X-ray imaging in animals 4Kodak in vivo imaging system: precise coregistration of molecular imaging with anatomical X-ray imaging in animals 5Kodak in vivo imaging system: precise coregistration of molecular imaging with anatomical X-ray imaging in animals 6Successful stabilization of gene expression profiles 2Successful stabilization of gene expression profiles 3
... EPICENTREs patented MasterAmp™ 10X PCR Enhancer ... and allows improved sensitivity and specificity ... Using MasterAmp PCR Enhancer in PCR ... DNA melting, increases enzyme?s thermal stability, ...
... Polystyrene covers can be ... Ridged covers for stacking ... Non-ridged covers for use with ... covers, ridged and non-ridged, are ...
Designed for use with all 96-well SPRI reagent kits. Used with round bottom 96-well microplates, and 96-well thermal cycling plates....
... Streptavidin-HRP Systems provide rapid, precise localization ... in frozen or paraffin-embedded tissue, cytospins ... also facilitate double or triple labeleing ... simultaneously with primary antibodies of different ...
Biology Products: