Navigation Links
Scientists find a new mechanism underlying depression
Date:1/8/2014

The World health Organization calls depression "the leading cause of disability worldwide," causing more years of disability than cancer, HIV/AIDS, and cardiovascular and respiratory diseases combined. In any given year, 5-7% of the world's population experiences a major depressive episode, and one in six people will at some point suffer from the disease.

Despite recent progress in understanding depression, scientists still don't understand the biological mechanisms behind it well enough to deliver effective prevention and therapy. One possible reason is that almost all research focuses on the brain's neurons, while the involvement of other brain cells has not been thoroughly examined.

Now researchers at the Hebrew University of Jerusalem have shown that changes in one type of non-neuronal brain cells, called microglia, underlie the depressive symptoms brought on by exposure to chronic stress. In experiments with animals, the researchers were able to demonstrate that compounds that alter the functioning of microglia can serve as novel and efficient antidepressant drugs.

The findings were published in Molecular Psychiatry, the premier scientific journal in psychiatry and one of the leading journals in medicine and the neurosciences. (See Dynamic microglial alterations underlie stress-induced depressive-like behavior and suppressed neurogenesis).

The research was conducted by Prof. Raz Yirmiya, director of the Hebrew University's Psychoneuroimmunology Laboratory, and his doctoral student Tirzah Kreisel, together with researchers at Prof. Yirmiya's laboratory and at the University of Colorado in Boulder, USA.

The researchers examined the involvement of microglia brain cells in the development of depression following chronic exposure to stress. Comprising roughly 10% of brain cells, microglia are the representatives of the immune system in the brain; but recent studies have shown that these cells are also involv
'/>"/>

Contact: Dov Smith
dovs@savion.huji.ac.il
972-258-82844
The Hebrew University of Jerusalem
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Boost careers of female scientists: Make sure women help choose meeting speakers
2. MBL scientists to study coastal waterbird habitats through funding for Obamas Climate Action Plan
3. Scientists uncover image of muscular dystrophy defect & design targeted drug candidates
4. Scientists look to tackle bacterium that is major cause of diarrhea, vomiting
5. Study led by NUS scientists provides new insights into cause of human neurodegenerative disease
6. Scientists find a groovy way to influence specialization of stem cells
7. WSU scientists find burglary-ring-like mechanism in lethal Contagion virus
8. UCLA stem cell scientists first to track joint cartilage development in humans
9. Sniffing out danger: Rutgers scientists say fearful memories can trigger heightened sense of smell
10. Scientists map food security and self-provision of major cities
11. Scientists identified T372R mutation as potential target for diagnosis and treatment of insulinoma
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists find a new mechanism underlying depression
(Date:8/28/2014)... alert the world to Global Warming, has called for ... underground. He says that Carbon Capture, combined with limits ... avoid global warming getting out of control over the ... made the call during his presentation to the International ... meeting to discuss Carbon Capture and Storage. , ...
(Date:8/28/2014)... (LMU) in Munich have assigned a number of ... arthropods. These animals lived in shallow marine habitats ... found in Jurassic strata. , Before they ... habitat and were fossilized some 435 million years ... the Silurian seas although they were not ...
(Date:8/27/2014)...  WaferGen Bio-systems, Inc. (NASDAQ: WGBS) today announced that ... of units of common stock and warrants at a ... $20 million, prior to deducting underwriting discounts and commissions ... and warrants are immediately separable and will be issued ... offering consists of 2,000 shares of common stock and ...
Breaking Biology News(10 mins):Global warming pioneer calls for CO2 to be taken from atmosphere and stored underground 2Paleontology: Oldest representative of a weird arthropod group 2WaferGen Bio-Systems Announces Successful Completion of Public Offering Raising $20 Million 2WaferGen Bio-Systems Announces Successful Completion of Public Offering Raising $20 Million 3
... invites all journalists to attend its 64th Annual Scientific ... field of aging from November 18 to 22 ... charge. An estimated 3,500 professionals are expected to ... Veterans Memorial Convention Center and Sheraton Boston Hotel. The ...
... Later this week, the American Society of Plant Biologists (ASPB) ... to chart the future of the field. The Plant ... plant science research community in a process that will develop ... over the next decade. The summit will bring together ...
... researchers could help develop culturally appropriate conservation efforts and ... southwest China where deforestation is a major environmental issue. ... Religion and the Cultural Studies program, and An Jing, ... Studies, found a distinct link between the strong religious ...
Cached Biology News:Join GSA in Boston for the nation's premier aging conference 2ASPB convenes leaders to chart future of plant science research 2Religion and ecology among China's Blang people 2
(Date:8/28/2014)... converters are important devices in spintronics, an electronic ... of electrons but also on their spin and ... of electric into magnetic signals and vice versa. ... from the Institute of Physics at Johannes Gutenberg ... UK, Prague, and Japan, has for the first ...
(Date:8/28/2014)... 2014  Next month, executives from clinical trial marketing firm ... beginning with Patient-Centered Clinical Trials 2014 , to be ... , September 4-5. Patient recruitment experts Bonnie A. ... will share insights on the benefits of employing an ... – from media to mobile apps – can be used ...
(Date:8/28/2014)... 2014  Armetheon, Inc. ( www.armetheon.com ), a ... late-stage cardiovascular drug candidates, today announced that it ... of financing. The Series A round was co-led ... participation from investors that included Atheneos Capital and ... Larry Hsu , the founder of Impax Laboratories. ...
(Date:8/28/2014)... A new market research report ... available from Strategic Consulting, Inc., the leading information ... Market Review, Fourth Edition: Global Review of Microbiology ... and compares microbiology test volumes, market values and ... Asia, and forecasts future volumes and market values ...
Breaking Biology Technology:A new, tunable device for spintronics 2A new, tunable device for spintronics 3BBK Worldwide Leads Sessions at Key September Events 2Armetheon Completes $7.0 Million Series A Financing 2Armetheon Completes $7.0 Million Series A Financing 32 Billion Industrial Microbiology Tests Conducted for Product Quality and Safety Worldwide 22 Billion Industrial Microbiology Tests Conducted for Product Quality and Safety Worldwide 3
... years, I have to admit that Ive never been there. ... Lever Bros. (now Unilever ) in New York City during ... young, Indian man with a doctorate and other degrees from the ... he had just arrived in New York without any contacts. He ...
... incredibly bullish , ,Plymouth, Wis. - After years ... like Rust Belt, Wisconsin got a much needed boost from ... 8, 2003 edition. In an interview with Jeff Gendell, a ... that the U.S. is about to enter the strongest recovery ...
... is a national leader in the total number of ... a significant catalyst for new job creation as well, ... University of Louisville who recently addressed an audience at ... lecture series at the MGE Innovation Center , ...
Cached Biology Technology:Midwest Biotech: Watch India, the Next Biotech Frontier 2Midwest Biotech: Watch India, the Next Biotech Frontier 3Midwest Biotech: Watch India, the Next Biotech Frontier 4Midwest Biotech: Watch India, the Next Biotech Frontier 5Wisconsin Manufacturing Poised For a Barrons Bounce 2Wisconsin Manufacturing Poised For a Barrons Bounce 3Business Incubators Grow Economy and Jobs 2Business Incubators Grow Economy and Jobs 3
Recognizes the ~115 kDa NMDA receptor NR1 subunit in rat cortex tissue extracts....
... formation of phosphodiester bonds in the presence ... hydroxyl and 5' phosphate termini. The unique ... can be performed in 5 minutes (1). ... this enzyme. A T4 DNA Ligase ...
Porcine Coronary Artery Smooth Muscle Cells (PCASMC) (>500,000 cells)...
Sulfadimethoxine (CH-2027)...
Biology Products: