Navigation Links
Scientists find a key element of lupus, suggesting better drug targets
Date:2/4/2013

non-existent, and all the other lupus-like manifestations were drastically reduced."

Next, the researchers sought to highlight specifically how pDCs promote lupus autoimmunity. For this they used a different mouse gene knockout, based on a mouse strain developed in the TSRI laboratory of Bruce Beutler, a long-time collaborator who has since moved to become the director of the Center for Genetics of Host Defense at the University of Texas Southwestern Medical Center.

Beutler's special mice lack a working gene for a protein called SLC15A4, and as a result of this mutation, the pDCs in these mice develop normally, but are largely unable to produce type I interferons in response to the usual stimuli. Such cells normally produce large amounts of interferons after detecting viral or bacterial genetic material. For this detection, they use a class of internal receptors called TLRs (toll-like receptors). Beutler received the 2011 Nobel Prize in Physiology or Medicine for his work on TLRs. His SLC15A4-mutant mice specifically lack the ability to respond to stimuli that would normally be detected by two of these receptors, TLR7 and TLR9. These same TLRs have been implicated in lupusthey apparently mistake self-nucleic acids for viral nucleic acids.

Working with Beutler, the TSRI team applied the SLC15A4 mutation to a strain of lupus mice to see if it would protect them from autoimmunity. And it did. "The usual lupus-like signs significantly decreased, and survival was extended," said Baccala.

A Potential Target

Baccala and Theofilopoulos now see SLC15A4 as a potential target for a lupus druga drug that, in principle, would prevent flare-ups of autoimmunity without suppressing other parts of the immune system as much as current therapies do. "The SLC15A4-mutant mice seem to be otherwise almost normal immunologically," said Baccala. "They can clear common viral infections, for example."

"We are now trying to find pha
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. Scientists notch a win in war against antibiotic-resistant bacteria
2. Plant scientists at CSHL demonstrate new means of boosting maize yields
3. Listening to cells: Scientists probe human cells with high-frequency sound
4. A*STAR scientists solve century-old mystery by finding stable haploid strains of Candida albicans
5. Joslin scientists find first human iPSC from patients with maturity onset diabetes of the young
6. Scientists uncover previously unknown mechanism of memory formation
7. Scientists trick iron-eating bacteria into breathing electrons instead
8. Damon Runyon Cancer Research Foundation grants prestigious awards to 17 young scientists
9. Virginia Tech computer scientists develop new way to study molecular networks
10. UCI neuroscientists create fiber-optic method of arresting epileptic seizures
11. Scientists discover needle in a haystack for muscular dystrophy patients
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists find a key element of lupus, suggesting better drug targets
(Date:8/27/2014)... health advocates, campaigns against trans-fats have largely succeeded ... taking aim at sugar for its potential contributions ... are still wrangling over the best way to ... an article in Chemical & Engineering News ... American Chemical Society. , In the article, Stephen ...
(Date:8/27/2014)... that piglets can be weaned later with no negative ... the study at the University,s Roseworthy campus, published in ... important finding for pig producers. It allows improvements in ... "Sows don,t usually start their oestrous cycles again during ... been weaned," says Ms Alice Weaver, PhD candidate with ...
(Date:8/27/2014)... of Warwick research finds , Gamblers show the ... new research has shown. , Researchers, led by Dr ... Psychology, conducted tests that found that both human gamblers ... high-value than low-value rewards. , Published in Biology ... show the important role that memories of previous biggest ...
Breaking Biology News(10 mins):Piglet weaning age no bar to litter frequency 2Gamblers are greedy bird-brains, University of Warwick research finds 2
... Patients suffering with end-stage renal disease could increase their ... than the conventional dialysis in clinics. A new study ... more intensive dialysis completed in a home setting. ... dialysis at home have better survival rates than patients ...
... Washington, D.C.The American Society for Plant Biology ... Department of Plant Biology, the Lawrence Bogorad Award ... major contributions in the development of fundamental tools ... our understanding of glucose, sucrose, ammonium, amino acid, ...
... Granada Department of Botanic have participated in an international ... plants to migrate to higher altitudes. The study recently ... in 66 summits of 17 European ranges between 2001 ... regions were selected in the Pyrenees (Ordesa) and Sierra ...
Cached Biology News:Carnegie's Wolf B. Frommer receives Bogorad Award for Excellence in Plant Biology 2Global warming has driven Europe's mountain plants to migrate 2.7 meters upwards in 7 years 2
(Date:8/27/2014)... Boca Raton, FL (PRWEB) August 27, 2014 ... that are applied through the use of a handheld ... consumers across the United States. , The brand ... care unit. BIOEQUA researchers were surprised to learn that ... to be made extremely small and delivered directly to ...
(Date:8/27/2014)... WriteResult, LLC – a premier provider ... shown superiority when it comes to meeting the needs ... portion of their most recent study closeout on-time and ... WriteResult’s digital writing platform to collect Patient Reported Outcomes ... complete drew data from a number of assessments including ...
(Date:8/26/2014)... Bellingham, WA (PRWEB) August 26, 2014 ... visions for next-generation wearable technology, and inspiration for ... highlights at this year’s brighter, busier SPIE ... California, Convention Center. More than 4,400 international scientists, ... conferences, courses, an exhibition, and industry sessions sponsored ...
(Date:8/26/2014)... has just been added to the growing case ... the next big thing in the high-tech world ... An international collaboration of researchers led by a ... Lawrence Berkeley National Laboratory (Berkeley Lab) has reported ... in photo-excited MX2 materials. The recorded charge transfer ...
Breaking Biology Technology:BIOEQUA'S EQUA ESSENTIAL Product Line Redefines Skin Care & Now Available in America 2A Perfect Record: WriteResult Maintains a 100% On-Time ePRO Record with Latest Irritable Bowel (IBS) Study Data Lock 2Brighter, Busier SPIE Optics + Photonics Draws International Crowd to San Diego 2Brighter, Busier SPIE Optics + Photonics Draws International Crowd to San Diego 3Brighter, Busier SPIE Optics + Photonics Draws International Crowd to San Diego 4Competition for graphene 2
... , , WORCESTER, Mass., ... announced today that Dr. Robert Lanza, its Chief Scientific Officer, ... Dr. Michio Kaku, an hour long radio program on science, ... on public radio in New York City (WBAI 99.5 FM), ...
... CHERRY HILL, N.J., Sept. 21 Nuvilex, Inc. ... its joint venture partner with Reme-Flu(TM), will be incorporating Syn-X9(TM) ... a homeopathic remedy designed to help prevent and treat flu-type ... . , , The ...
... , , , ... (Nasdaq: VOLC ), a leader in the development, manufacturing ... and peripheral artery disease, announced today its participation in the 2009 ... 21-25. Volcano programming for TCT includes a first look at new ...
Cached Biology Technology:Dr. Robert Lanza Featured on Michio Kaku's 'Explorations in Science' 2Dr. Robert Lanza Featured on Michio Kaku's 'Explorations in Science' 3Nuvilex, Inc. Announced that Reme-Flu(TM) will Incorporate Proprietary Syn-X9(TM) Delivery Technology into its Product Formulation 2Nuvilex, Inc. Announced that Reme-Flu(TM) will Incorporate Proprietary Syn-X9(TM) Delivery Technology into its Product Formulation 3Volcano Corporation Announces Schedule of Events for the 2009 Transcatheter Cardiovascular Therapeutics (TCT) Conference 2Volcano Corporation Announces Schedule of Events for the 2009 Transcatheter Cardiovascular Therapeutics (TCT) Conference 3Volcano Corporation Announces Schedule of Events for the 2009 Transcatheter Cardiovascular Therapeutics (TCT) Conference 4Volcano Corporation Announces Schedule of Events for the 2009 Transcatheter Cardiovascular Therapeutics (TCT) Conference 5Volcano Corporation Announces Schedule of Events for the 2009 Transcatheter Cardiovascular Therapeutics (TCT) Conference 6
Agarose-LE, 500 g. Suitable for soft agarose cloning. Nuclease-free.Gel point (1.5%): 36 1.5 C, EEO (-mr): 1200 g/cm2. Category: Nucleotides & Enzymes & Biochemicals, Ultrapure Biochemicals ....
Request Info...
Request Info...
Limit of detection: <5 pg/ml...
Biology Products: