Navigation Links
Scientists find a key element of lupus, suggesting better drug targets
Date:2/4/2013

ound evidence that a powerful class of immune-stimulating chemicals, known as type I interferons, are essential to the vicious cycle of lupus autoimmunity.

The cycle apparently begins when certain immune cells mistakenly detect self-proteins and nucleic acids as "foreign" and begin pumping out type I interferons. This mobilizes other elements of the immune system, including the antibody response, and soon autoantibodies are attacking self-molecules in healthy cells. The autoantibodies in turn present these "foreign" molecules to type I interferon-producing cells, adding fuel to the autoimmune fire.

Lab-dish evidence has suggested that the key producers of type I interferons in lupus are a relatively sparse class of immune cells known as plasmacytoid dendritic cells (pDCs). In the new study, Theofilopoulos and his colleagues sought more conclusive evidence of pDCs' role, using mouse models of lupus.

In Search of Evidence

The experiments were led by first author Roberto Baccala, an associate professor in the TSRI Department of Immunology and Microbial Science who has worked with Theofilopoulos on lupus-related research for the past two decades. To help determine whether lupus can develop in the absence of pDCs, the TSRI scientists collaborated with Keiko Ozato, an expert on immune cell genetics at the National Institutes of Health. Ozato has developed a strain of mice that have no pDCs due to lack of a key gene (IRF8) needed for these cells' development.

The team knocked out this gene in another strain of mice that normally succumbs to a lupus-like autoimmune disease with age. These mice grew up without pDCs and, as a result, were largely protected from the disease.

"When we injected a standard inducer of interferons into these mice, they didn't produce detectable interferons," said Baccala. "And when we watched the animals for the usual development of lupus, we found that autoantibodies were practically
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. Scientists notch a win in war against antibiotic-resistant bacteria
2. Plant scientists at CSHL demonstrate new means of boosting maize yields
3. Listening to cells: Scientists probe human cells with high-frequency sound
4. A*STAR scientists solve century-old mystery by finding stable haploid strains of Candida albicans
5. Joslin scientists find first human iPSC from patients with maturity onset diabetes of the young
6. Scientists uncover previously unknown mechanism of memory formation
7. Scientists trick iron-eating bacteria into breathing electrons instead
8. Damon Runyon Cancer Research Foundation grants prestigious awards to 17 young scientists
9. Virginia Tech computer scientists develop new way to study molecular networks
10. UCI neuroscientists create fiber-optic method of arresting epileptic seizures
11. Scientists discover needle in a haystack for muscular dystrophy patients
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists find a key element of lupus, suggesting better drug targets
(Date:4/27/2015)... more than four decades, AUVSI,s Unmanned Systems ... event for the unmanned land, sea, and air industries. ... local, national, or trade news organization interested in gathering ... applications of unmanned technologies. The conference will explore the ... and how it will soon impact the lives of ...
(Date:4/21/2015)... , April 21, 2015 ... evolving government policies are boosting access control systems market ... According to a recently published report by TechSci ... 2020 ", the access control systems market in ... USD1.2 billion by 2020.The access control systems market in ...
(Date:4/17/2015)... , April 17, 2015 ... concerns, and technological advancement to drive biometric systems ... until 2020   According to a ... Biometric Systems Market Forecast &  Opportunities, 2020 ", biometric systems market in ... to register growth at CAGR of over 22% ...
Breaking Biology News(10 mins):UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 2UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 3UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 4UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 5Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 2Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 3Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 2Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 3
... , AMES, Iowa A research team led by Edward ... discovered the crystal structures of pumps that remove heavy metal ... The findings are published in the Sept. 23 issue of ... State associate professor of chemistry, of physics and astronomy, of ...
... rhino with a ridiculously supersized head." "Fifteen long, pointed sideways ... one at the tip of each cheek bone, and ten across ... large horn over the nose and short, blunt eye horns that ... to describe two newly discovered species of dinosaurs with looks only ...
... This release is available in French . ... of acutely hospitalized patients, according to a study carried out ... affiliated Lady Davis Institute for Medical Research (LDI). In ... randomly assigned to receive either vitamin C or vitamin D ...
Cached Biology News:Iowa State, Ames Lab researchers identify structure that allows bacteria to resist drugs 2New species of multi-horned dinosaurs unearthed in Utah 2Vitamin C rapidly improves emotional state of acutely hospitalized patients, say LDI researchers 2
(Date:6/1/2015)... 2015 Esperance Pharmaceuticals Inc. today reported positive ... EP-100 in ovarian cancer patients resistant to paclitaxel. EP-100 ... destroy cancer cells that overexpress luteinizing hormone-releasing hormone (LHRH) ... a wide range of cancers. Results ... EP-100 were presented at the 2015 ASCO Annual ...
(Date:6/1/2015)... May 29, 2015 Research and ... addition of the "2015 Strategies in ... to their offering. This new ... immunoprotein diagnostic market, including emerging tests, technologies, ... profiles of leading suppliers. Companies ...
(Date:6/1/2015)... Research and Markets( http://www.researchandmarkets.com/research/5j2hpk/2015_strategies ) ... "2015 Strategies in the US Point-of-Care/POC Clinical ... This new 373-page report contains ... of the POC clinical chemistry market, including ... trends, competitive landscape, and emerging opportunities for ...
(Date:6/1/2015)... 2015 Research and Markets( http://www.researchandmarkets.com/research/n2rvxp/2015_assessments ... "2015 Assessments of Leading Microbiology Market ... Market Entrants" report to their offering. ... VPGMarketResearch.com provides insightful profiles of leading microbiology ... The report presents strategic assessments, including ...
Breaking Biology Technology:Esperance Reports Positive EP-100 Phase ll Results in Ovarian Cancer at 2015 ASCO Annual Meeting 2Esperance Reports Positive EP-100 Phase ll Results in Ovarian Cancer at 2015 ASCO Annual Meeting 3Assessments of Leading Microbiology Market Players 2015 - Profiles of Major Suppliers and Recent Market Entrants 2
... MADISON, WI. - EraGen Biosciences , a ... commercializes products and technologies that accelerate the drug ... announced today that it has selected ITOCHU ... distribute its integrated phylogenomics product, Master Catalog ...
... Wisconsin Technology Network has received from NorthStar Economics an ... primer for Wisconsin companies seeking information about risk capital ... have agreed to exclusively excerpt their report in four-installments ... , , Seed-Stage Venture Financing , , Seed-Stage ...
... are focused on being profitable and productive. Technology ... years, you'll see an increase in the adoption of ... businesses. Our local businesses will incorporate technology to ... dollars through their doors. , ,There are ...
Cached Biology Technology:EraGen Expands in Japan 2Seed-Stage Venture Financing 2Seed-Stage Venture Financing 3Seed-Stage Venture Financing 4Seed-Stage Venture Financing 5Doing it Right: Business IT Fusion for the Future 2Doing it Right: Business IT Fusion for the Future 3
... Immunogen: Synthetic peptide derived from the ... 36 protein This peptide sequence is ... another Zymed polyclonal Connexin 36 antibody Cat. ... Connexin 36. Reactivity: Mouse (positive control: ...
Invitrogen's Calcium Phosphate Transfection Kit provides high-quality reagents to enable the introduction of DNA into tissue culture cells via calcium phosphate co-precipitation....
...
...
Biology Products: