Navigation Links
Scientists find a fingerprint of evolution across the human genome
Date:4/8/2008

larger noncoding stretches, called introns, that are removed from the RNA working copy of the DNA before the protein is made.

Signs of splicing

Previous researchers assumed that mutations in the middle of introns do not affect the final protein, so they simply accumulate. In the new work, however, the researchers found signs that evolution rejects some types of mutations even in these regions of the genome. Although the selection is weak, introns are not neutral, in their effect on survival, says CSHL professor Michael Zhang, a bioinformatics expert who headed the research team.

To look for selection, CSHL researcher Chaolin Zhang, a doctoral candidate at Stony Brook University, looked in the human genome for a subtle statistical imbalance in how often various letters appear. The researchers attribute this imbalance to special short stretches of DNA that mark regions to be removed. Unless these signal sequences are sprinkled throughout an intron, the data suggest, it may not be properly spliced out, with potentially fatal consequences. Other sequences must likewise be preserved in the regions to be retained.

The scientists found a preference for some letters across intron regions, and the opposite preference in coding regions. Together, these regions make up at least a third of the genome, which is thus under selective pressure during evolution. The result supports other recent studies that suggest that, although most DNA does not code for proteins, much of it is nonetheless biologically important.

In addition to demonstrating how splicing affects genetic evolution, the statistical analysis identified possible signaling sequences, some that were already known and others that are new. According to co-author Adrian Krainer, a CSHL professor and splicing expert, the exciting thing will be to experimentally test whether these predicted elements are really true.


'/>"/>

Contact: Jim Bono
bono@cshl.edu
516-367-8455
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1 2

Related biology news :

1. Death protein research secures funding for UCF scientists
2. Yale scientists visualize the machinery of mRNA splicing
3. Cold Spring Harbor Laboratory scientists devise potential approach to treat spinal muscular atrophy
4. Scientists discover 356 animal inclusions trapped in 100 million years old opaque amber
5. Great Ape Trust to gather internationally recognized scientists for Decade of the Mind III
6. CSHL scientists part of team that discovers role of rare gene mutations in schizophrenia
7. CSHL scientists identify a mechanism that helps fruit flies lock-in memories
8. Scientists find that squid beak is both hard and soft, a material that engineers want to copy
9. Scientists launch first comprehensive database of human oral microbiome
10. NYU scientists set stage for understanding how color vision is processed
11. Scientists launch human oral microbiome database
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/14/2014)... – Like discriminating thieves, prostate cancer tumors scavenge and ... body. But such avarice may be a fatal weakness. ... way to kill prostate cancer cells by delivering a ... destroys the diseased cells brimming with the mineral, leaving ... two drugs already commercially available for other uses, could ...
(Date:10/14/2014)... millions of years since T. rex took ... University scientists is breathing life back into dinosaurs using ... The research has important implications for how dinosaurs used ... the sense of smell and cool their brains. ... doctoral student Jason Bourke, lead author of the new ...
(Date:10/14/2014)... of the planet,s leading questions is how to produce ... variable climate. The Food and Agriculture Organization of the ... over the next 40 years to feed a growing ... the necessary rise in food production. Plants—grains, cereals, ... supporting livestock. Current research must tap into our ...
Breaking Biology News(10 mins):Prostate cancer's penchant for copper may be a fatal flaw 2Dinosaur breathing study shows that noses enhanced smelling and cooled brain 2Dinosaur breathing study shows that noses enhanced smelling and cooled brain 3Building a bridge from basic botany to applied agriculture 2Building a bridge from basic botany to applied agriculture 3
... 22, 2010) The National Science Foundation has awarded ... Biological Laboratory $1.7 million to repair and rebuild its ... the pier has played an instrumental role in the ... change, fisheries management and the health of the Chesapeake ...
... reporting the development and successful initial testing of a new ... to be given as nose drops rather than injected. It ... they say. The report appears in ACS, Molecular Pharmaceutics ... note that brain cancer is difficult to treat, partly because ...
... water," which resembles powdered sugar, could provide a new ... greenhouse gas that contributes to global warming, scientists reported ... Society. The powder shows bright promise for a number ... be a greener, more energy-efficient way of jump-starting the ...
Cached Biology News:UMCES Chesapeake Biological Laboratory to rebuild historic research pier 2
(Date:10/22/2014)... -- Research and Markets  has announced the addition ... Application, Geography - Global Analysis and Forecast (2014 - ... Organic electronics, also called as polymer electronics or plastic ... with small conductive molecules and electrically conductive polymers. It ... are carbon based, made using synthetic strategies developed in ...
(Date:10/20/2014)... 20, 2014 Asterias Biotherapeutics, Inc. (NYSE ... signed a Notice of Grant Award (NGA) with ... October 1, 2014.  The NGA provides for the ... release of additional grant funds pursuant to the ... clinical development of Asterias, product, AST-OPC1. The grant ...
(Date:10/20/2014)... (PRWEB) October 20, 2014 ... Sidney Kimmel Cancer Center at Thomas Jefferson University ... , Through the Strategic Alliance Partnership program, the ... will collaborate to raise awareness of the Center’s ... and other projects. Clinicians and other health care ...
(Date:10/19/2014)... 2014 NextCODE Health, which enables clinicians and researchers ... time, today announced the launch of its new genomic data ... the American Society of Human Genetics (ASHG) annual meeting in ... up and apply for free beta access, visit www.nextcode.com ... can be viewed here . The Exchange: ...
Breaking Biology Technology:Global Organic Electronics (Semiconductor, Conductive, Dielectric and Substrate) Market - Analysis and Forecast (2014 - 2020) 2Global Organic Electronics (Semiconductor, Conductive, Dielectric and Substrate) Market - Analysis and Forecast (2014 - 2020) 3Asterias Biotherapeutics Announces Notice of Grant Award with CIRM for Phase 1/2a Clinical Trial of AST-OPC1 in Complete Cervical Spinal Cord Injury 2Asterias Biotherapeutics Announces Notice of Grant Award with CIRM for Phase 1/2a Clinical Trial of AST-OPC1 in Complete Cervical Spinal Cord Injury 3Asterias Biotherapeutics Announces Notice of Grant Award with CIRM for Phase 1/2a Clinical Trial of AST-OPC1 in Complete Cervical Spinal Cord Injury 4Sidney Kimmel Cancer Center at Thomas Jefferson University Partners With OncLive 2Sidney Kimmel Cancer Center at Thomas Jefferson University Partners With OncLive 3The NextCODE Exchange: The first global, real-time system for sharing full-resolution genomic data 2The NextCODE Exchange: The first global, real-time system for sharing full-resolution genomic data 3
... Sept. 23, 2011 Citizens Bank today announced that ... a major expansion by The Wistar Institute that includes ... historic facility at 36th and Spruce streets in University ... an international leader in basic biomedical research, particularly cancer ...
... working in collaboration with researchers from Grenoble and Tokyo, have ... more powerful computers. They were able to define two little ... to select a single electron from one of them using ... neighbouring QD. A single electron "surfs" thus from one quantum ...
... have for the first time provided details of ... layers of epitaxial graphene on silicon carbide wafers. ... of gas-phase silicon in the high-temperature furnace used ... for growing thin layers of graphene on silicon ...
Cached Biology Technology:Citizens Bank Provides $70 Million in Financing Toward $100 Million Expansion of The Wistar Institute 2Like fish on waves: electrons go surfing 2Like fish on waves: electrons go surfing 3Controlling silicon evaporation allows scientists to boost graphene quality 2Controlling silicon evaporation allows scientists to boost graphene quality 3
Polyclonal Antibody to CLAN...
Request Info...
IRF7 Immunogen: Synthetic peptide corresponding to residues E(463) G T Q R E G V S S L D S S S(477) of human IRF7. Storage: -20 C, Avoid Freeze/Thaw Cycles...
Rabbit polyclonal to TetR ( Abpromise for all tested applications). Antigen: Synthetic peptide: AQKLGVEQPTLYWHVKNKR, corresponding to amino acids 31 - 49 of TetR...
Biology Products: