Navigation Links
Scientists find a fingerprint of evolution across the human genome
Date:4/8/2008

larger noncoding stretches, called introns, that are removed from the RNA working copy of the DNA before the protein is made.

Signs of splicing

Previous researchers assumed that mutations in the middle of introns do not affect the final protein, so they simply accumulate. In the new work, however, the researchers found signs that evolution rejects some types of mutations even in these regions of the genome. Although the selection is weak, introns are not neutral, in their effect on survival, says CSHL professor Michael Zhang, a bioinformatics expert who headed the research team.

To look for selection, CSHL researcher Chaolin Zhang, a doctoral candidate at Stony Brook University, looked in the human genome for a subtle statistical imbalance in how often various letters appear. The researchers attribute this imbalance to special short stretches of DNA that mark regions to be removed. Unless these signal sequences are sprinkled throughout an intron, the data suggest, it may not be properly spliced out, with potentially fatal consequences. Other sequences must likewise be preserved in the regions to be retained.

The scientists found a preference for some letters across intron regions, and the opposite preference in coding regions. Together, these regions make up at least a third of the genome, which is thus under selective pressure during evolution. The result supports other recent studies that suggest that, although most DNA does not code for proteins, much of it is nonetheless biologically important.

In addition to demonstrating how splicing affects genetic evolution, the statistical analysis identified possible signaling sequences, some that were already known and others that are new. According to co-author Adrian Krainer, a CSHL professor and splicing expert, the exciting thing will be to experimentally test whether these predicted elements are really true.


'/>"/>

Contact: Jim Bono
bono@cshl.edu
516-367-8455
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1 2

Related biology news :

1. Death protein research secures funding for UCF scientists
2. Yale scientists visualize the machinery of mRNA splicing
3. Cold Spring Harbor Laboratory scientists devise potential approach to treat spinal muscular atrophy
4. Scientists discover 356 animal inclusions trapped in 100 million years old opaque amber
5. Great Ape Trust to gather internationally recognized scientists for Decade of the Mind III
6. CSHL scientists part of team that discovers role of rare gene mutations in schizophrenia
7. CSHL scientists identify a mechanism that helps fruit flies lock-in memories
8. Scientists find that squid beak is both hard and soft, a material that engineers want to copy
9. Scientists launch first comprehensive database of human oral microbiome
10. NYU scientists set stage for understanding how color vision is processed
11. Scientists launch human oral microbiome database
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/23/2014)... Chrysomya megacephala is commonly found in dead ... the time of death, referred to as the post ... C. megacephala from Tamil Nadu is provided ... molecular characterization through generation of DNA barcoding. This study, ... access Biodiversity Data Journal . , Chrysomya ...
(Date:7/23/2014)... struggle to deal with ever-growing piles of electronic waste ... just how much there is and where it really ... Science & Technology , their study found that nearly ... into just seven developing countries with major potential ... Knut Breivik and colleagues note that the export from ...
(Date:7/23/2014)... sulfur-oxidizing bacterial group called SUP05 will play an increasingly ... world,s oceans as oxygen minimum zones expand, according to ... the National Academy of Sciences . , University of ... anoxic fjord, Canada,s Saanich Inlet, to chart how microbial ... "Our study paints a very detailed picture of how ...
Breaking Biology News(10 mins):Dead body feeding larvae useful in forensic investigations 2Research charts the ecological impact of microbial respiration in the oxygen-starved ocean 2
... Connie Hedegaard, the EU commissioner for Climate Action, ... new Nordic centre for Europe,s main climate innovation ... entrepreneurs, businesses, climate professionals, students and government officials ... European partnership to work on innovative solutions for ...
... and technology (S&T) eroded further during the last decade, ... their innovation capacities. According to a report released today ... body of the National Science Foundation (NSF) and an ... economies, taken together, now perform a larger share of ...
... D.C., February 6, 2014Dietary supplement users take these ... effort to develop a healthier lifestyle, according to ... , a peer-reviewed scientific publication. The review, "Health ... Nutrition Journal .2014, 13:14), co-authored by Council for ...
Cached Biology News:European Union launches Nordic climate innovation center 2European Union launches Nordic climate innovation center 3US lead in science and technology shrinking 2US lead in science and technology shrinking 3US lead in science and technology shrinking 4Scientific review points to supplement users engaging in a pattern of healthy habits 2
(Date:7/23/2014)... July 23, 2014 International research and ... that its biobanking project, Provia Laboratories , has ... growing Advisory Board. Scott Wolf , CEO of ... Dr. Vaught onboard with Provia’s ever-expanding Advisory Board. His ... Provia’s management team brings to this field, should help ...
(Date:7/23/2014)... worldwide conservation efforts have made great strides in saving ... China, there are over 65 giant panda reserves that ... despite these efforts, just 1596 pandas remain in the ... zoos hope to save the panda by improving genetic ... the wild. Just how are these high-profile programs doing ...
(Date:7/23/2014)... Researchers at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR), the Vienna ... Lublin have succeeded in embedding nearly perfect semiconductor ... method of producing hybrid nanowires, very fast and ... single chip in the future. The research results ... Research . , Nano-optoelectronics are considered the cornerstone ...
(Date:7/23/2014)... 23, 2014  AuraSense Therapeutics, the pioneer in developing ... regulatory and immunotherapeutic agents, announced today that ... Therapeutics, executive leadership team as chief financial ... to joining AuraSense Therapeutics, Mr. Snyder was ... of Cellular Dynamics International Inc., where he ...
Breaking Biology Technology:Provia Laboratories Adds Dr. Jim Vaught, Ph.D., Former Chief of BBRB, to Advisory Board 2Provia Laboratories Adds Dr. Jim Vaught, Ph.D., Former Chief of BBRB, to Advisory Board 3Provia Laboratories Adds Dr. Jim Vaught, Ph.D., Former Chief of BBRB, to Advisory Board 4A crystal wedding in the nanocosmos 2AuraSense Therapeutics Appoints Biotechnology Veteran David S. Snyder as Chief Financial Officer 2
... Pharma AG today,announced that the US Food and ... (IND) application submitted by Nitec for the,initiation of ... results of a European Phase III trial (CAPRA-1;,Circadian ... dossier for marketing authorization in Europe. The FDA,s,acceptance ...
... and advantageous for the U.S. Army,s Chemical Materials Agency ... waste during regular chemical agent disposal operations, says a ... committee that wrote the report also determined that the ... the submission of data from previous trial burns -- ...
... Pacific Northwest National Laboratory,have discovered a way to ... creation of a portable biosensor that can address ... nerve agents, the need to quickly distinguish between ... , The sensor components resemble a pregnancy test ...
Cached Biology Technology:Nitec's IND Application for Clinical Development With Lodotra Accepted by the FDA 2Nitec's IND Application for Clinical Development With Lodotra Accepted by the FDA 3Report recommends off-site disposal of secondary waste 2Report recommends off-site disposal of secondary waste 3Report recommends off-site disposal of secondary waste 4Truly sick or simply scared? 2