Navigation Links
Scientists find Achilles' heel in life-threatening malaria parasites
Date:4/20/2012

Scientists have identified a link between different strains of malaria parasites that cause severe disease, which could help develop vaccines or drugs against life-threatening cases of the infection.

Researchers have identified a key protein that is common to many potentially fatal forms of the condition, and found that antibodies that targeted this protein were effective against these severe malaria strains.

The protein has sticky properties that enable it to bind to red blood cells and form dangerous clumps that can block blood vessels. These clumps, or rosettes, can cause severe illness, including coma and brain damage. Presently, between 10 and 20 per cent of people with severe malaria die from it, and the disease which is spread by blood-sucking mosquitoes claims about one million lives per year.

Malaria parasites, once in the bloodstream, are able to alter the protein molecules on their surfaces to evade attack by the immune system. These surface proteins are usually poor targets for treatments or vaccines because they are highly variable between different malaria parasite strains. Now, researchers have found that the surface proteins of rosette-forming parasites share similarities that may allow them to act as a target for treatments to block progress of the disease.

Scientists from the University of Edinburgh worked with collaborators from Cameroon, Mali, Kenya and The Gambia to test their antibodies against parasites collected from patients. The study, published in PLoS Pathogens, was supported by the Wellcome Trust.

Professor Alexandra Rowe of the University of Edinburgh's School of Biological Sciences, who led the study, said: "We knew that clusters, or rosettes, of blood cells were found in many cases of severe or life-threatening malaria, so we looked at rosette-forming parasites and found a common factor that we could target with antibodies. We hope this discovery will inform new treatments or vaccines to block the formation of rosettes and so prevent many life-threatening cases of malaria."


'/>"/>

Contact: Catriona Kelly
catriona.kelly@ed.ac.uk
44-131-651-4401
University of Edinburgh
Source:Eurekalert

Related biology news :

1. Scientists find that neurological changes can happen due to social status
2. Scientists discover switch in plants to create flowers
3. Merkin Family Foundation to fund next generation of Broad Institute scientists
4. Scripps Research Institute scientists develop antidote for cocaine overdose
5. Scientists trace evolutionary history of what mammals eat
6. Scientists find neural stem cell regulator
7. Scientists identify FLT3 gene as a valid therapeutic target in acute myeloid leukemia
8. Scientists complete first-ever emperor penguin count from space
9. Scientists count penguins from space
10. Researchers use game to change how scientists study disease outbreaks
11. Salk scientists redraw the blueprint of the bodys biological clock
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2016)... Ampronix facilitates superior patient care by providing unparalleled technology to leaders of ... the latest premium product recently added to the range of products distributed by Ampronix. ... ... ... Medical Display- Ampronix News ...
(Date:5/3/2016)... VILNIUS, Lithuania , May 3, 2016 /PRNewswire/ ... today released the MegaMatcher Automated Biometric Identification ... deployment of large-scale multi-biometric projects. MegaMatcher ABIS can ... and accuracy using any combination of fingerprint, face ... of MegaMatcher SDK and MegaMatcher ...
(Date:4/19/2016)... The new GEZE SecuLogic access ... "all-in-one" system solution for all door components. It can ... door interface with integration authorization management system, and thus ... minimal dimensions of the access control and the optimum ... offer considerable freedom of design with regard to the ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... 2016 , ... Supplyframe, the Industry Network for electronics hardware ... . Located in Pasadena, Calif., the Design Lab’s mission is to bring together ... built and brought to market. , The Design Lab is Supplyframe’s physical representation ...
(Date:6/23/2016)... 2016  Blueprint Bio, a company dedicated to identifying, ... community, has closed its Series A funding round, according ... "We have received a commitment from Forentis Fund ... to meet our current goals," stated Matthew Nunez ... to complete validation on the current projects in our ...
(Date:6/23/2016)... ... June 23, 2016 , ... Regulatory Compliance Associates® Inc. (RCA), ... free webinar on Performing Quality Investigations: Getting to Root Cause. ... no charge. , Incomplete investigations are still a major concern to the Regulatory ...
(Date:6/22/2016)... , June 22, 2016 Cell ... will allow them to produce up to one ... one lot within one week. These high-quality, consistent ... laboriously preparing cells and spend more time doing ... through a proprietary, high-volume manufacturing process that produces ...
Breaking Biology Technology: