Navigation Links
Scientists film inner workings of the immune system
Date:12/3/2008

Forget what's number one at the box office this week. The most exciting new film features the intricate workings of the body, filmed by scientists using ground-breaking technology.

For the first time in Australia, scientists at Sydney's Centenary Institute have filmed an immune cell becoming infected by a parasite and followed the infection as it begins to spread throughout the body.

Professor Wolfgang Weninger, head of the Immune Imaging program at the Centenary Institute, says the discovery (published in PLoS Pathogens) was made possible using high powered multi-photon microscopy which allows real cells to be viewed in real time.

"Using multi-photon microscopy, we studied dendritic cells in the skin. Under normal conditions we found the cells in the epidermis (top layer) were static, whereas in the dermis (second layer) they were very active, moving around as though seeking out pathogens," explains Professor Weninger. "Once we established this, it was fascinating to introduce the Leishmania infection and watch as the parasite was picked up by the cells and the process by which it began to spread throughout the body."

Leishmaniasis affects up to 12 million people in parts of Africa, the Middle East and South America. The disease causes skin sores and can affect internal organs such as the spleen, liver and bone marrow. If left untreated, it can be fatal.

The ability to visually follow a pathogen on its journey through the immune cells provides critical insight for future vaccine design and has potential to improve current vaccinations.

"We now have a general idea of how pathogens are recognised by the immune system and which cells are involved," Professor Weninger says. "This means we can look at identifying the molecules responsible for the uptake of Leishmania infection and these molecules could become vaccine targets. Additionally, we can investigate the immune responses of other infections which could lead to better vaccines."

"On the other side of the story, scientists can now visualise the pathway of current vaccines in the immune system, providing greater understanding and the potential for refining current interventions against disease."

Centenary Institute Executive Director, Professor Mathew Vadas, says the multi-photon microscope used to film this immune process is the Hubble telescope of medical research.

"The Hubble allowed the universe to be seen with absolute clarity, which wasn't before possible from earth," he explains. "This is exactly the same as multi-photon microscopy it provides a unique and innovative view of cells, unveiling a whole new understanding of how immune processes work."


'/>"/>

Contact: Erin Sharp
e.sharp@centenary.org.au
61-295-656-118
Research Australia
Source:Eurekalert

Related biology news :

1. Rooted plants move mysteriously down greenways, scientists say
2. Caltech scientists show function of helical band in heart
3. Argonne scientists discover possible mechanism for creating handedness in biological molecules
4. Scientists developing food allergy treatment
5. Wistar scientists find key to keeping killer T cells in prime shape for fighting infection, cancer
6. CSHL scientists discover a new way in which epigenetic information is inherited
7. Caltech scientists develop barcode chip for cheap, fast blood tests
8. UNC scientists teach enzyme to make synthetic heparin in more varieties
9. Childrens Hospital scientists achieve repair of injured heart muscle in lab tests of stem cells
10. Scientists shed light on evolution of gene regulation
11. Scientists build roach motel for nasty bugs of the bacterial variety
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/2/2016)... Feb. 2, 2016 This BCC Research ... market by reviewing the recent advances in high ... drive the field forward. Includes forecast through 2019. ... the challenges and opportunities that exist in the ... solution developers, as well as IT and bioinformatics ...
(Date:2/1/2016)... , February 1, 2016 ... advancements to drive global touchfree intuitive gesture control market ... --> Rising sales of consumer electronics coupled with ... control market size through 2020 ... electronics coupled with new technological advancements to drive global ...
(Date:1/25/2016)...   Unisys Corporation (NYSE: UIS ) today announced ... International Airport, New York City , to help ... to enter the United States using passports ... pilot testing of the system at Dulles last year. The ... during January 2016. --> pilot testing of the ...
Breaking Biology News(10 mins):
(Date:2/11/2016)... Feb. 11, 2016  Dovetail Genomics™ LLC today announced ... program for a planned metagenomic genome assembly service. ... metagenomic genome assembly method in a talk on Friday, ... & Technology conference in Orlando, Fla. ... complex datasets is difficult. Using its proprietary ...
(Date:2/11/2016)... MIAMI (PRWEB) , ... February 11, 2016 , ... ... in regenerative medicine, has announced a new agreement with Bankok,Thailand-based Global Stem Cells ... researchers and phsyicians in 15 Latin American countries, including Mexico, Costa Rica, Dominican ...
(Date:2/10/2016)... , Feb. 10, 2016  The Maryland House of ... has announced that University of Maryland School of Medicine ... and University of Maryland Medical System President and CEO ... "Speaker,s Medallion," the highest honor given to the public ... Dean Reece and Mr. Chrencik for ...
(Date:2/10/2016)... (NYSE MKT: ISR), a medical technology company and innovator ... treatment of prostate, brain, lung, head and neck and ... second quarter and six months of fiscal 2016, which ... --> Revenue was $1.19 million for ... 31, 2015, a 12% increase compared to $1.07 million ...
Breaking Biology Technology: