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Scientists favor needles over tablets for global vaccinations
Date:4/26/2010

chronic parasitic infections can derail vaccination programs that are effective in healthy individuals.

Because only bystander cells in the same lymph node as those responding to the parasite infection are affected by active cytokines, this study suggests that people infected with gastrointestinal worms may respond better to vaccines injected under the skin than those given by mouth. This is critical information for the development of globally-effective vaccination strategies.

Although the current study will not necessarily lead to improved treatments for worm infections themselves, by understanding how worm infection affects other immune responses, scientists may be able to improve the efficacy of ordinary vaccines like those used to prevent polio, measles, malaria and TB in those regions of the world where most children are already infected with parasitic worms prior to receiving their childhood immunizations.


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Contact: Brian Turner
bturner@trudeauinstitute.org
518-891-3080
Trudeau Institute
Source:Eurekalert  

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