Navigation Links
Scientists explain how 'death receptors' designed to kill our cells may make them stronger
Date:6/1/2009

It turns out that from the perspective of cell biology, Nietzsche may have been right after all: that which does not kill us does make us stronger. In a review article published in the June 2009 print issue of The FASEB Journal (http://www.fasebj.org), scientists from the Mayo Clinic explain how cell receptors (called "death receptors") used by the body to shut down old, diseased, or otherwise unwanted cells (called "apoptosis") may also be used to make cells heartier when facing a wide range of illnesses, from liver disease to cancer.

"Increasing our knowledge of how death receptors function will allow us to develop better and more effective therapies for several human diseases," said Gregory J. Gores, M.D., Chair of the Division of Gastroenterology and Hepatology at the Mayo Clinic in Rochester, Minn., and one of the scientists involved in the work.

In their article, Gores and his colleague, Maria Guicciardi, also from the Mayo Clinic, described the various molecular pathways activated by death receptors and the proteins involved in the process. Specifically, they looked at how these proteins interact with each other and how they redistribute within a cell. Death receptors are an essential tool for the immune system to eliminate cells that have been overtaken by viruses, undergone potentially harmful genetic modifications, or have become too old to function properly. Understanding the exact sequence of events that occurs after death receptors are activated, including identifying key proteins involved in the processes, may allow researchers to develop entirely new therapeutics. These therapeutics not only would give doctors the ability to choose when and if certain cells are taken out of service, but they would also give doctors the ability to trigger cells to shift into "survival mode."

"As far as names are concerned, nothing in biology sounds more intimidating than 'death receptors,'" said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "Fortunately for us, when scientists look at the intricate machinery of how cells die, they dig up clues to longer, healthier lives."


'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Related biology news :

1. Caltech scientists reveal how neuronal activity is timed in brains memory-making circuits
2. Scientists develop a new HIV microbicide -- and a way to mass produce it in plants
3. City rats loyal to their hoods, scientists discover
4. Scientists find formula to uncover our planets past and help predict its future
5. Scientists announce top 10 new species, issue SOS
6. Scientists announce top 10 new species; issue SOS
7. Queens scientists discover eco-friendly wood dissolution
8. Stanford scientists find heat-tolerant coral reefs that may resist climate change
9. Scientists work to plug microorganisms into the energy grid
10. Scientists identify worlds largest leatherback turtle population
11. UCSB scientists document fate of huge oil slicks from seeps at coal oil point
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/2/2016)... Va. , Feb. 2, 2016   ... award from the U.S. Army Research Office and ... the range and sensitivity of the company,s ... Past Accounting Mission and, more generally, defense-related DNA ... DNA phenotyping capabilities (predicting appearance and ancestry from ...
(Date:1/28/2016)... -- Synaptics (NASDAQ: SYNA ), a leading developer of human ... December 31, 2015. --> --> ... 2 percent compared to the comparable quarter last year to $470.5 ... $35.0 million, or $0.93 per diluted share. ... quarter of fiscal 2016 grew 9 percent over the prior year ...
(Date:1/22/2016)... 22, 2016 ... the "Global Biometrics Market in Retail ... --> http://www.researchandmarkets.com/research/p74whf/global_biometrics ) has ... Biometrics Market in Retail Sector 2016-2020" ... Research and Markets ( http://www.researchandmarkets.com/research/p74whf/global_biometrics ) ...
Breaking Biology News(10 mins):
(Date:2/4/2016)... ... February 04, 2016 , ... ... and compliance training, today announced an interactive FDA compliance training course, ... RAPS (Regulatory Affairs Professional Society) accredited interactive course on Morf Playbook—now conveniently available ...
(Date:2/4/2016)... 4, 2016  Sangamo BioSciences, Inc. (NASDAQ: SGMO ... that Edward Lanphier , Sangamo,s president and chief ... of Sangamo,s ZFP Therapeutic ® development programs and ... pm ET on Thursday, February 11, 2016, at the ... The conference is being held in New ...
(Date:2/4/2016)... ... February 04, 2016 , ... ... takes place February 5-6 at the University’s student center, Kehr Union, located ... as workshops and competitions for ample networking, learning and collaborating opportunities. , ...
(Date:2/4/2016)... 4, 2016  CytoSorbents Corporation (NASDAQ: CTSO ... flagship CytoSorb® blood filter to treat deadly inflammation ... world, announced that CEO Dr. Phillip Chan ... Capital Group,s 2016 Disruptive Growth & Healthcare Conference, ... Conference Presentation Details: Where: Convene ...
Breaking Biology Technology: