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Scientists discover the specific types of macrophages that affect Crohn's disease severity
Date:2/28/2014

cal blood monocytes, which are the most pro-inflammatory. This suggests that the CD14hiHLA-DRdim macrophages are driving the inflammation seen in Crohn's disease, exacerbating the inflammation and leading to tissue destruction.

"This work provides new leads for drugs and therapeutic targets for Crohn's disease and possibly other conditions that involve runaway inflammation," said John Wherry, Ph.D., Deputy Editor of the Journal of Leukocyte Biology. "Most of our therapies for intestine inflammatory diseases like Crohn's involve non-specific immunosuppression that have variable efficacy and many side effects. These new studies suggest that targeting specific cell types could increase the ability to specifically treat disease, reduce unwanted side effects, and hopefully, help people lead healthier lives."


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Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

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