Navigation Links
Scientists discover the proteins that control development of varicose veins
Date:9/29/2011

Bethesda, MDA new discovery published in the October 2011 print issue of The FASEB Journal (http://www.fasebj.org) explains for the first time what kicks off the process that causes varicose veins. In the article, researchers from Germany describe a single protein that binds to DNA to control gene function (called "transcription factor AP-1") and the subsequent production of a newly discovered set of proteins that significantly affect the development of varicose veins.

"We very much hope that our findings spur further studies focusing on the mechanisms underlying this widespread and precarious but still largely neglected venous disease," said Thomas Korff, Ph.D., study author from the Institute of Physiology and Pathophysiology at the University of Heidelberg in Heidelberg, Germany. "In the long run, such approaches will result in the development of a drug therapy that improves the quality of life for all people suffering from varicose veins."

To make this discovery, Korff and colleagues increased the blood pressure in a single vein of the ears of white mice, and followed the resulting changes in the size and architecture of the adjacent veins for several days. These changes were further analyzed in the abundance and activity of specific proteins in the veins connected to the one with increased blood pressure, and results were compared to those obtained from human varicose veins. By inhibiting the transcription factor AP-1 in the mouse ear model, synthesis of proteins associated with varicose remodeling and the proliferation of blood vessel smooth muscle cells were significantly reduced, and the varicose remodeling process was virtually abolished. AP-1 was inhibited by decoy oligonucleotides (decoy ODN), a well-studied class of nucleic acid-based drugs.

"Most people know varicose veins as an unsightly reminder of aging," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal, "but for some, varicose veins cause significant pain that affects the quality and in some cases, length of life. While surgery may be beneficial in some cases, it's not the ideal solution. This research really opens the doors for an entirely new approach to treatment and prevention."


'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Related biology news :

1. Carnegie Mellon scientists track neuronal stem cells using MRI
2. Scientists discover a master key to unlock new treatments for autoimmune disorders
3. Barrow scientists identify new stem cell activity in human brain
4. President to honor high achieving, early career NOAA scientists
5. Scientists model the pathways of pain-blocking meds
6. Scientists lay out plans for efficient harvesting of solar energy
7. Scientists probe Indian Ocean for clues to worldwide weather patterns
8. Ties between scientists in South Africa and Europe to strengthen
9. NIH Directors Awards go to 3 Johns Hopkins scientists
10. 2 Scripps Research scientists win prestigious NIH Innovator Awards
11. Scientists turn back the clock on adult stem cells aging
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/12/2016)... WearablesResearch.com , a brand of Troubadour Research & ... Q1 wave of its quarterly wearables survey. A particular ... a program where they would receive discounts for sharing ... "We were surprised to see that so many ... CEO of Troubadour Research, "primarily because there are segments ...
(Date:4/26/2016)... and LONDON , April ... part of EdgeVerve Systems, a product subsidiary of ... today announced a partnership to integrate the Onegini ...      (Logo: http://photos.prnewswire.com/prnh/20151104/283829LOGO ) ... their customers enhanced security to access and transact ...
(Date:4/14/2016)... Israel , April 14, 2016 ... Authentication and Malware Detection, today announced the appointment of ... assumed the new role. Goldwerger,s leadership appointment ... on the heels of the deployment of its platform ... BioCatch,s behavioral biometric technology, which discerns unique cognitive and ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... Diego, CA (PRWEB) , ... June 27, 2016 , ... ... solutions for clinical trials, announced today the Clinical Reach Virtual Patient Encounter ... their care circle with the physician and clinical trial team. , Using the CONSULT ...
(Date:6/27/2016)... 27, 2016  Liquid Biotech USA ... of a Sponsored Research Agreement with The University ... (CTCs) from cancer patients.  The funding will be ... correlate with clinical outcomes in cancer patients undergoing ... then be employed to support the design of ...
(Date:6/24/2016)... 24, 2016 Epic Sciences unveiled a ... susceptible to PARP inhibitors by targeting homologous recombination ... The new test has already been incorporated into ... cancer types. Over 230 clinical trials ... pathways, including PARP, ATM, ATR, DNA-PK and WEE-1. ...
(Date:6/23/2016)... ... June 23, 2016 , ... Mosio, a ... eBook, “Clinical Trials Patient Recruitment and Retention Tips.” Partnering with experienced clinical research ... by providing practical tips, tools, and strategies for clinical researchers. , “The landscape ...
Breaking Biology Technology: