Navigation Links
Scientists discover the proteins that control development of varicose veins
Date:9/29/2011

Bethesda, MDA new discovery published in the October 2011 print issue of The FASEB Journal (http://www.fasebj.org) explains for the first time what kicks off the process that causes varicose veins. In the article, researchers from Germany describe a single protein that binds to DNA to control gene function (called "transcription factor AP-1") and the subsequent production of a newly discovered set of proteins that significantly affect the development of varicose veins.

"We very much hope that our findings spur further studies focusing on the mechanisms underlying this widespread and precarious but still largely neglected venous disease," said Thomas Korff, Ph.D., study author from the Institute of Physiology and Pathophysiology at the University of Heidelberg in Heidelberg, Germany. "In the long run, such approaches will result in the development of a drug therapy that improves the quality of life for all people suffering from varicose veins."

To make this discovery, Korff and colleagues increased the blood pressure in a single vein of the ears of white mice, and followed the resulting changes in the size and architecture of the adjacent veins for several days. These changes were further analyzed in the abundance and activity of specific proteins in the veins connected to the one with increased blood pressure, and results were compared to those obtained from human varicose veins. By inhibiting the transcription factor AP-1 in the mouse ear model, synthesis of proteins associated with varicose remodeling and the proliferation of blood vessel smooth muscle cells were significantly reduced, and the varicose remodeling process was virtually abolished. AP-1 was inhibited by decoy oligonucleotides (decoy ODN), a well-studied class of nucleic acid-based drugs.

"Most people know varicose veins as an unsightly reminder of aging," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Page: 1 2

Related biology news :

1. Carnegie Mellon scientists track neuronal stem cells using MRI
2. Scientists discover a master key to unlock new treatments for autoimmune disorders
3. Barrow scientists identify new stem cell activity in human brain
4. President to honor high achieving, early career NOAA scientists
5. Scientists model the pathways of pain-blocking meds
6. Scientists lay out plans for efficient harvesting of solar energy
7. Scientists probe Indian Ocean for clues to worldwide weather patterns
8. Ties between scientists in South Africa and Europe to strengthen
9. NIH Directors Awards go to 3 Johns Hopkins scientists
10. 2 Scripps Research scientists win prestigious NIH Innovator Awards
11. Scientists turn back the clock on adult stem cells aging
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2014)... persist in a cold, dark world. A UT microbiology ... waters and sediments from a shallow lake deep beneath ... supports microbial ecosystems. , The National Science Foundation-funded ... for life in other extreme environments, both on Earth ... in the current edition of the science journal ...
(Date:8/20/2014)... Using population-based screening outcomes of approximately 3 million infants, ... researchers at the University of Massachusetts Medical School, have ... can be successfully implemented across public health newborn screening ... the Aug. 20 issue of the Journal of ... the rate of SCID in newborns is higher than ...
(Date:8/20/2014)... EUGENE, Ore. -- When are athletes who have suffered ... of Oregon study has found that high school athletes ... within 60 days experience a significant regression in their ... , The regression, as seen in changes in their ... of 19 athletes. Ten of the 12 had returned ...
Breaking Biology News(10 mins):University of Tennessee research uncovers subglacial life beneath Antarctic ice sheet 2Newborn screening expansion offers early diagnosis and treatment to infants with SCID 2Newborn screening expansion offers early diagnosis and treatment to infants with SCID 3Recovery reversal seen in Oregon study of returning concussed athletes 2Recovery reversal seen in Oregon study of returning concussed athletes 3
... losses invariably raise questions about why such losses matter ... Biologists have traditionally responded to such questions by citing ... by biodiversity--benefits like controlling pests and diseases, promoting the ... water, among many others. Nevertheless, many of these presumed ...
... important to life and the human body. They are also ... much we still don,t know or understand about them. ... particular type of protein that speeds up, or catalyzes, chemical ... or body, enzymes can quickly lose their shape and denature. ...
... College Park, Md. (April 6, 2011) -- A new ... Thomas Cesario and Peter Rentzepis promises to unlock the ... perhaps cancer tumors as well. Photosensitive chemicals ... radicals when illuminated. These radicals are very active chemically, ...
Cached Biology News:Precedent-setting evidence of the benefits of biodiversity 2Precedent-setting evidence of the benefits of biodiversity 3Precedent-setting evidence of the benefits of biodiversity 4Nano fit-ness: Helping enzymes stay active and keep in shape 2New device promises safer way to deliver powerful drugs 2
(Date:8/21/2014)... , Aug. 21, 2014  Four-dimensional (4-D) printing ... based on external stimuli such as changes in ... a disruptive effect in multiple industries.  In the ... landscape by printing objects ranging from human organs ... sectors. Logo - http://photos.prnewswire.com/prnh/20140820/138289 ...
(Date:8/21/2014)... August 21, 2014 Ontotext S4 ... by Ontotext . Now the same enterprise ... of structured and unstructured data is available to start-ups ... of enterprise technology. Organizations that do not have resources ... management can use S4 since there is no need ...
(Date:8/21/2014)... 21, 2014 SoundConnect , ... recognized as one of the nation’s Fastest Growing ... for the 2nd consecutive year. Inc. magazine today ... Inc. 500|5000, an exclusive ranking of the nation's ... comprehensive look at the most important segment of ...
(Date:8/20/2014)... 20, 2014 Clintrax Global, Inc., a ... Raleigh, NC , recently announced ... Vice President of Administration. As ... corporate processes, including their alignment with company objectives ... worked as an HR executive, specializing in needs ...
Breaking Biology Technology:Frost & Sullivan: 4-D Printing to Usher in Age of Low-Labor, Fast-Paced Product Manufacturing 2Frost & Sullivan: 4-D Printing to Usher in Age of Low-Labor, Fast-Paced Product Manufacturing 3Frost & Sullivan: 4-D Printing to Usher in Age of Low-Labor, Fast-Paced Product Manufacturing 4Ontotext Releases Text Mining & Semantic Technology Running in the Cloud – Welcome to “S4? 2Ontotext Releases Text Mining & Semantic Technology Running in the Cloud – Welcome to “S4? 3Ontotext Releases Text Mining & Semantic Technology Running in the Cloud – Welcome to “S4? 4SoundConnect Returns on Inc. 5000 List of Fastest Growing Companies 2SoundConnect Returns on Inc. 5000 List of Fastest Growing Companies 3Clintrax Global, Inc. Announces Addition to Executive Team 2
... surgery experts listed in the Trusted LASIK Surgeons ... American Academy of Ophthalmology (AAO) annual meeting in ... Dr. James McCulley, Dr. R. Wayne Bowman, Dr. ... Koffler, all leading refractive eye surgery specialists educated ...
... (NRC) committee today issued a highly critical report ... to better understand the environment, health and safety ... those potential risks. , The report, Review ... ,and Safety Research Needs for Engineered Nanoscale Materials, ...
... Dec. 10 The 14th Annual National Ergonomics Conference and ... 5 was yet again the largest annual gathering of ergonomics ... with over 1,200 attendees representing nearly all of the 50 ... Zealand and Kuwait. , , ...
Cached Biology Technology:Top LASIK and Refractive Experts in Trusted LASIK Surgeons Directory Present Research and Educate Their Peers at Annual AAO Meeting in Atlanta 2Top LASIK and Refractive Experts in Trusted LASIK Surgeons Directory Present Research and Educate Their Peers at Annual AAO Meeting in Atlanta 3Top LASIK and Refractive Experts in Trusted LASIK Surgeons Directory Present Research and Educate Their Peers at Annual AAO Meeting in Atlanta 4Top LASIK and Refractive Experts in Trusted LASIK Surgeons Directory Present Research and Educate Their Peers at Annual AAO Meeting in Atlanta 5Top LASIK and Refractive Experts in Trusted LASIK Surgeons Directory Present Research and Educate Their Peers at Annual AAO Meeting in Atlanta 6Top LASIK and Refractive Experts in Trusted LASIK Surgeons Directory Present Research and Educate Their Peers at Annual AAO Meeting in Atlanta 7Top LASIK and Refractive Experts in Trusted LASIK Surgeons Directory Present Research and Educate Their Peers at Annual AAO Meeting in Atlanta 8Top LASIK and Refractive Experts in Trusted LASIK Surgeons Directory Present Research and Educate Their Peers at Annual AAO Meeting in Atlanta 9Panel blasts federal nanotech risk research strategy 2National Ergonomics Expo Sees 86% On-Site Exhibitor Renewal Rate for 2009; New Products from Contour Design, Equipois, Goldtouch and Herman Miller Win 2008 NECE Attendees' Choice New Product Awards 2
Immunogen: Synthetic peptide (aa sequence is considered to be commercially sensitive) Storage: -20 C, Avoid Freeze/Thaw Cycles...
The S. cerevisiae Hansen strains are the parental yeast strains from which the deletions were derived....
The DNA DipStick Kit is ideal for estimating nucleic acid concentrations and approximate yields. Works with ss- and ds-DNA, RNA, and oligonucleotides at concentrations as low as 0.1 ng/l....
Request Info...
Biology Products: