Navigation Links
Scientists discover that thyroid cancer cells become less aggressive in outer space
Date:1/30/2014

For those who think that space exploration offers no tangible benefits for those of us on earth, a new research discovery involving thyroid cancer may prove otherwise. In a new report appearing in the February 2014 issue of The FASEB Journal, researchers from Germany and Denmark show that some tumors which are aggressive on earth are considerably less aggressive in microgravity. By understanding the genetic and cellular processes that occur in space, scientists may be able to develop treatments that accomplish the same thing on earth.

"Research in space or under simulated microgravity using ground-based facilities helps us in many ways to understand the complex processes of life and this study is the first step toward the understanding of the mechanisms of cancer growth inhibition in microgravity," said Daniela Gabriele Grimm, M.D., a researcher involved in the work from the Department of Biomedicine, Pharmacology at Aarhus University in Aarhus, Denmark. "Ultimately, we hope to find new cellular targets, leading to the development of new anti-cancer drugs which might help to treat those tumors that prove to be non-responsive to the currently employed agents."

To make their discovery, Grimm and colleagues used the Science in Microgravity Box (SIMBOX) experimental facility aboard Shenzhou-8, which was launched on October 31, 2011. Cell feeding was automatically performed in space on day five and automated cell fixation was conducted on day 10. Inflight control was achieved by using a centrifuge in space. On November 17, 2011, Shenzhou-8 landed and the experimental samples were analyzed. Additional cells were analyzed using a random positioning machine which aims to achieve simulated microgravity conditions on the ground by rotating a sample around two axes operated in a random real direction mode. Both cell types were investigated with respect to their gene expression and secretion profiles, employing modern molecular biological techniques, such as whole genome microarrays and multi-analyte profiling. Results suggested that the expression of genes indicating a high malignancy in cancer cells may be down-regulated under altered gravitational stimulation.

"We are just at the beginning of a new field of medicine that studies the effects of microgravity on cell and molecular pathology. Space flight affects our bodies, both for good and bad," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "We've known that microgravity can cause some microorganisms to become more virulent and that prolonged microgravity has negative effects on the human body. Now, we learn that it's not all bad news: what we learn from cells in space should help us understand and treat malignant tumors on the ground."


'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Related biology news :

1. Scientists find genetic mechanism linking aging to specific diets
2. University of Hawaii scientists make a big splash
3. Plant scientists unravel a molecular switch to stimulate leaf growth
4. Scientists reveal why life got big in the Earths early oceans
5. Johns Hopkins scientists identify a key to bodys use of free calcium
6. Scripps Florida scientists offer new insight into neuron changes brought about by aging
7. Spider silk ties scientists up in knots
8. York scientists investigate the fiber of our being
9. Scientists warn: Conservation work in zoos is too random
10. Scientists develop promising drug candidates for pain, addiction
11. Damon Runyon Cancer Research Foundation grants prestigious awards to 20 top young scientists
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/18/2017)... Minn. , Jan. 18, 2017 ... technology company that supports the entire spectrum of ... has been another record-breaking year for the organization ... market interest in MedNet,s eClinical products and services. ... the tremendous marketplace success of iMedNet ...
(Date:1/11/2017)... , Jan. 11, 2017 Intoxalock, a ... with the release of its patent-pending calibration device. With ... reliably perform calibrations, securely upload data logs and process ... the customer. "Fighting drunk driving through the ... the public at large, but also for the customer ...
(Date:1/4/2017)... VEGAS , Jan. 4, 2017  For the thousands of attendees ... a global leader in connected health and biometric measurement devices and services, ... monitors. On display in A&D Medical,s special CES Exhibit ... represent the ongoing expansion of the company,s WellnessConnected product platform.  ... ...
Breaking Biology News(10 mins):
(Date:1/23/2017)... ... 23, 2017 , ... Calvert Labs, Inc. announced today that ... Director, Safety Pharmacology. Dr. Thomas earned his M.Sc. and Ph.D. in Pharmacology ... an academic and industry preclinical drug developer spans more than three decades. ...
(Date:1/21/2017)... ... 20, 2017 , ... G&L Scientific Inc, a leading provider ... ), has announced the opening of new offices in Cambridge, Massachusetts, strengthening and ... This is the latest step in G&L’s expansion of its global clinical consulting ...
(Date:1/21/2017)... 20, 2017 Bioptix, Inc. (Nasdaq: ... that on January 14, 2017 the Board of Directors ... Company will terminate certain employees associated with the September ... Company commenced terminations on January 16, 2017 and terminations ... Company may pay severance benefits in certain circumstances of ...
(Date:1/20/2017)... -- Stock-Callers.com explores the Biotech industry to ... recent performances of select equities. In this morning,s lineup ... Abeona Therapeutics Inc. (NASDAQ: ABEO ), Theravance ... Therapeutics Inc. (NASDAQ: SAGE ). According to ... market size is expected to reach $604.40 billion by 2020 due to ...
Breaking Biology Technology: