Navigation Links
Scientists discover that a specific enzyme inhibitor may help control lung inflammation
Date:1/4/2011

All of us may be able to breathe a little easier now that scientists from Pennsylvania have found a new therapeutic target for controlling dangerous inflammation in the lungs. A new research report in the January 2011 issue of the Journal of Leukocyte Biology (http://www.jleukbio.org) suggests that blocking the activation of an enzyme called delta-protein kinase C (delta-PKC) could protect the lungs from neutrophil-mediated damage, which can result in out of control inflammation. In an animal model of acute respiratory distress syndrome (ARDS), inhibiting delta-PKC in the lungs showed dramatically reduced inflammation, thereby protecting the lungs from further damage.

"ARDS is a major public health problem and one of the leading causes of death in intensive care units. It is characterized by excessive pulmonary inflammation and neutrophil infiltrations of the lung," said Laurie E. Kilpatrick, Ph.D., co author of the study from the Center for Inflammation, Translational and Clinical Lung Research and Department of Physiology at Temple University School of Medicine in Philadelphia. "While no specific pharmacologic therapeutics are available to treat this disease, control of delta-PKC activity may offer a unique therapeutic target for the treatment of ARDS and prevent the significant morbidity and mortality associated with sepsis and trauma."

To make this discovery, Kilpatrick and colleagues used a rat model of severe inflammation or sepsis that produces lung injury. The animals were divided into two groups; one group received the inhibitor directly into the lungs and the other group received a placebo. After 24 hours, the placebo group showed signs of lung injury and illness, lung tissue damage and breathing problems. In contrast, the group that received the delta-PKC inhibitor had markedly reduced evidence of lung injury and distress. These results suggest that delta-PKC is an important regulator
'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Page: 1 2

Related biology news :

1. Jefferson scientists deliver toxic genes to effectively kill pancreatic cancer cells
2. Scientists identify novel inhibitor of human microRNA
3. Argonne scientists peer into heart of compound that may detect chemical, biological weapons
4. MU scientists go green with gold, distribute environmentally friendly nanoparticles
5. Scientists identify gene that may contribute to improved rice yield
6. Scientists discover why a mothers high-fat diet contributes to obesity in her children
7. MU scientists see how HIV matures into an infection
8. Earth scientists keep an eye on Texas
9. Thinking it through: Scientists call for policy to guide biofuels industry toward sustainability
10. Scientists identify a molecule that coordinates the movement of cells
11. Scientists Find new migratory patterns for Mediterranean and Western Atlantic bluefin tuna
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... and Markets ( http://www.researchandmarkets.com/research/wxdglm/global_wearable ) has ... Technologies Market and Applications, Opportunities, Industry Analysis, Segmentation, ... report to their offering. , ... be worn on the user,s body and have ...
(Date:12/24/2014)... its launch in December 2014, the 1U™ app ... trying to remember their usernames and passwords through replacing the ... To assist people who have struggled to remember usernames and ... and focuses on redefining identity, announced today that it is ...
(Date:12/22/2014)... Holiday Season may be the brightest ever for the ... long anticipated floodgates for consumer biometrics may finally be ... tablets, and wearable mobile devices that incorporate biometrics will ... nearly 4.8 billion biometric devices by 2020.   ...
Breaking Biology News(10 mins):Global Wearable Technologies Market and Applications, Opportunities, Industry Analysis, Segmentation, Size, Growth, Share, Overview, Trends and Forecast 2014-2020 21U Offers Best Solution to the Username / Password Dilemma: For FREE! 21U Offers Best Solution to the Username / Password Dilemma: For FREE! 3First Season of Holiday Shopping with Mobile Biometric Payments Wraps Up With a Present for Biometrics Industry: A Rosy Forecast for More Than 2 Billion Users of 4.8 Billion Mobile Biometric Devices by 2020 2
... from geosciences and civil and environmental engineering at Virginia ... universities and five other schools awarded a multi-million dollar ... one of only two such consortiums funded by the ... for the Environmental Implications of Nanotechnology (CEIN). Total funding ...
... finish of some insects or the deep black of ... on the nanostructure of a fly,s eyes, according to ... rapidly and inexpensively copy biological surface structures. "Only ... successful," says Akhlesh Lakhtakia, the Charles Godfrey Binder (Endowed) ...
... of American Scientists has chosen Mark D. Levine, director of ... as the recipient of the 2008 FAS Public Service Award ... his work in China to build a strong energy program." ... was part of a major study, "A Time to Choose," ...
Cached Biology News:NSF funds multi-university center to study environmental implications of nanotechnology 2NSF funds multi-university center to study environmental implications of nanotechnology 3Coating copies microscopic biological surfaces 2Coating copies microscopic biological surfaces 3FAS honors Mark D. Levine with 2008 Public Service Award 2FAS honors Mark D. Levine with 2008 Public Service Award 3FAS honors Mark D. Levine with 2008 Public Service Award 4
(Date:1/22/2015)... DE (PRWEB) January 22, 2015 Controlled ... Pistoia Alliance, which helps companies check the legal requirements ... to expand to China. , As their international ... are globally adopting software solutions built as a result ...
(Date:1/22/2015)... PALO ALTO, Calif. , Jan. 22. 2015  Varian Medical ... equipment and software, has been honored for its commitment to ... most sustainable companies. Varian is the highest ranked healthcare equipment ... ranking, announced today during the World Economic Forum at ...
(Date:12/24/2014)... YORK , Dec. 24, 2014 PlasmaTech Biopharmaceuticals, Inc. ... critical areas, announced the closing of an underwritten public offering ... up to an aggregate 3,500,000 shares of common stock, at ... warrant.  The warrants have a per share exercise price of ...
(Date:12/24/2014)... 2014 Earlier this year in a June ... the Adult Stem Cell Technology Center, LLC ( ASCTC ) ... property of adult tissue stem cells. His title “Asymmetric ... for the Future,” embodied the essence of his message to ...
Breaking Biology Technology:Global Compliance Service for Controlled Substances to Expand to China 2Varian Honored Among World's 100 Most Sustainable Corporations 2PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 2PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 3Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 2Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 3Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 4
... have made a breakthrough toward creating nanocircuitry on graphene, ... silicon as the building block of transistors. They have ... thermochemical nanolithography (TCNL) for creating nanowires, tuning the electronic ... thereby allowing it to switch from being an insulating ...
... oxide, a single-atomic-layered material made by reacting graphite powders ... interest from scientists because of its ability to easily ... scientists believe could be used to produce low-cost carbon-based ... assistant professor of materials science and engineering, and his ...
... Germany and LAUSANNE, Switzerland and ... Medicines Initiative for,Diabetes"), a public private consortium funded by ... a project focusing on,pancreatic islet cell function and survival. ... biomarkers and tools to pave the way,for improved disease ...
Cached Biology Technology:Scientists strive to replace silicon with graphene on nanocircuitry 2Scientists strive to replace silicon with graphene on nanocircuitry 3Researchers discover new properties of World's thinnest material 2Launch of IMIDIA - An Innovative Medicines Initiative Project for Diabetes 2Launch of IMIDIA - An Innovative Medicines Initiative Project for Diabetes 3Launch of IMIDIA - An Innovative Medicines Initiative Project for Diabetes 4
... Design with Purpose -- ... MS provide the highest level ... performance in an affordable, easy-to-use ... autosampler and workstation guarantees success ...
EnzChek cellulase substrate *blue fluorescent, 339/452...
Homo sapiens 4-aminobutyrate aminotransferase Antigen: Recombinant Protein...
... sizing single-stranded RNA ranging from 0.5 kb to 10 ... consists of nine bands in even increments (0.5 1 ... to simplify size estimation. The 1.5 kb band is ... and identification of RNA bands on the gel. All ...
Biology Products: