Navigation Links
Scientists discover small RNAs that regulate gene expression and protect the genome
Date:5/13/2008

gulators.

A New Class of RNA

Previously, researchers had recognized two classes of regulatory small RNA molecules in fruit flies, each with different protein partners. One class, called microRNAs, appears throughout the organism and acts to regulate the activity of many genes by joining with a special protein called Argonaute 1. A second class of RNA molecules, called piRNAs, occurs only in cells of the sex organs, and joins with different proteins, called Piwi proteins. Together, they act as a kind of immune system to suppress genetic interlopers called transposable elements, which were discovered at CSHL by Nobel laureate Barbara McClintock more than a half century ago, and which in certain cases can cause genomic havoc that underlies disease.

Dr. Hannon and his colleagues looked for RNA molecules that partner with a different protein, Argonaute 2, that belongs to the same family as Argonaute 1 and the Piwi proteins. Using advanced sequencing technology, they found that these small-RNA partners were distinct from either of the previously known classes of small RNAs. The new small-RNA class both modifies gene activity and suppresses transposable elements, thus serving as a defense mechanism.

These findings, the scientists write in a newly published paper in Nature, expands the known repertoire of small RNAs in fruit flies, and further blurs distinctions between the previously identified classes of small RNAs.

Pseudogenes: Not Just Junk

In related research, Hannon and his colleagues have published a paper announcing their discovery of a new source of regulatory RNA in mice. Many RNA sequences, such as microRNAs, are flagged as regulatory molecules because they physically fold on themselves. Special proteins recognize the resulting double-stranded RNA, and chemically slice it to release regulatory RNA snippets.

The CSHL team found that double-stranded structures also form from pseudogenes.
'/>"/>

Contact: Jim Bono
bono@cshl.edu
516-367-8455
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Argonne scientists use lasers to align molecules
2. Too hot to handle! Scientists identify heat sensing regulator
3. Scientists dig deeper into the genetics of schizophrenia by evaluating microRNAs
4. Scientists endure Arctic for last campaign prior to CryoSat-2 launch
5. Scientists discover why plague is so lethal
6. UF scientists discover compound that could lead to new blood pressure drugs
7. UIC scientists discover how some bacteria survive antibiotics
8. Scientists aim to boost world energy supplies -- with microbes!
9. Scientists determine drug target for the most potent botulinum neurotoxin
10. Scientists make chemical cousin of DNA for use as new nanotechnology building block
11. Scientists find stem cells for the first time in the pituitary
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... , Dec. 15, 2014 The Defense Logistics ... to detect and prevent counterfeit microcircuits from entering into ... performing an in-house microcircuit anti-counterfeit initiative dubbed DNA marking. ... while increasing their reliability throughout the supply chain. The ...
(Date:12/17/2014)... 2014 Valencell, a leader in performance biometric data ... industry leaders such as Intel, Jabra, Atlas, and Scosche ... products. These products will be showcased at CES 2015, ... . "Our partners choose PerformTek ...
(Date:12/17/2014)... 16, 2014  Automation is fundamentally transforming the travel experience ... borders. Over the past decade, ePassports, biometric readers, and ... process through border control via eGates and Automated Passport ... seaports, and land borders across the globe. ...
Breaking Biology News(10 mins):Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 2Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 3Valencell PerformTek Biometrics Power the Most Accurate Wearables at CES 2015 2Automated Border Control (ABC) Transforms the Global Travel Experience With More Than 2500 ABC eGates and APC Kiosks Deployed In Airports, Seaports, and Land Borders Worldwide 2
... 2010) The New York Stem Cell Foundation (NYSCF) today ... postdoctoral scientists join 15 accomplished stem cell researchers from leading ... NYSCF has awarded 23 fellowships to date. ... most competitive postdoctoral fellowship programs in the world, has so ...
... year The International Institute for Species Exploration at Arizona State ... previous calendar year. The list for 2009 was published to ... birth of Carl Linnaeus. It contains only two new plant ... Botanical Journal of the Linnean Society . ...
... SPRING HARBOR, N.Y. (Tues., June 1, 2010) -- ... frequently used techniques in RNA analysis. Electrophoresis is ... quality assessment. Gels are involved in a wide ... and analyzing processing reactions. The two most common ...
Cached Biology News:NYSCF awards fellowships to 8 innovative stem cell scientists 2NYSCF awards fellowships to 8 innovative stem cell scientists 3Rare carnivorous plant on top 10 list of newly discovered species 2Electrophoresis of RNA, avian imaging featured in June's Cold Spring Harbor Protocols 2
(Date:1/22/2015)... , Jan. 22, 2015   Cypher Genomics, Inc., ... Inc. (NASDAQ: SQNM ), the leading ... for next generation noninvasive prenatal tests (NIPT). Through ... technology, called Mantis™, to advance analysis of clinically-relevant ...
(Date:1/22/2015)... 2015   GenoSpace , a precision medicine software company that ... broad use of genomic, imaging and other biomedical data in ... Michelle Munson , CEO of Aspera, an IBM Company, to ... http://photos.prnewswire.com/prnh/20150122/170713 "We are pleased to ...
(Date:12/25/2014)... 2014 The report “Service Quality Management ... & Provider Type - Global Advancements, Worldwide Forecasts & ... in-depth analysis and forecasting of revenues. , Browse ... pages and in-depth TOC on “Service Quality Management (SQM) ...
(Date:12/24/2014)... and NEW YORK , Dec. 24, 2014 ... advancing patient care in critical areas, announced the closing of ... and warrants to purchase up to an aggregate 3,500,000 shares ... share and $.01 per warrant.  The warrants have a per ...
Breaking Biology Technology:Cypher Genomics and Sequenom Announce Development Agreement 2Cypher Genomics and Sequenom Announce Development Agreement 3Cypher Genomics and Sequenom Announce Development Agreement 4GenoSpace Expands Board with Appointment of Michelle Munson 2Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 2Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 3Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 4PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 2PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 3
... MOUNTAIN VIEW, Calif., March 12 Alexza,Pharmaceuticals, Inc. (Nasdaq: ... for its fiscal year ended December 31, 2007, on ... financial markets. The Company will,host an investor conference call ... at 5:00 p.m. Eastern Time that same day. A,replay ...
... In this Podcast you,will learn about how plant ... stress., Climatic conditions such as heat or cold ... out well or badly. Because whenever these,conditions are not ... On top of that the reality today is that ...
... PAREXEL International,Corporation (Nasdaq: PRXL ), a ... Fisher as a Vice President and General,Manager ... Ms.,Fisher brings more than 20 years of ... this position, Ms. Fisher leads a global,team ...
Cached Biology Technology:Alexza to Announce 2007 Financial Results and Update Its Clinical Pipeline on Monday, March 17, 2008 2Alexza to Announce 2007 Financial Results and Update Its Clinical Pipeline on Monday, March 17, 2008 3BASF Podcast - Better Harvest in Spite of Climate Stress 2BASF Podcast - Better Harvest in Spite of Climate Stress 3PAREXEL Appoints Leading Biopharmaceutical Marketing Expert Jacque Fisher to Medical Communications Services Executive Team 2PAREXEL Appoints Leading Biopharmaceutical Marketing Expert Jacque Fisher to Medical Communications Services Executive Team 3PAREXEL Appoints Leading Biopharmaceutical Marketing Expert Jacque Fisher to Medical Communications Services Executive Team 4
... to SARA ( Abpromise for all ... Synthetic peptide: PVPKEMEQPV QTEEEDVELP conjugated to KLH, ... fly (Drosophila melanogaster) SARA. Conserved sequence ... Gene ID: 9372 ...
Rabbit polyclonal to Bag5 ( Abpromise for all tested applications). entrezGeneID: 9529 SwissProtID: Q9UL15...
AADAC Immunogen: AADAC (NP_001077, 201 a.a. ~ 301 a.a) partial recombinant protein with GST tag. Storage: -20 C, Avoid Freeze/Thaw Cycles *Available for distribution in the US only...
RNA polymerase sigma 70 Immunogen: Recombinant, full length protein. Storage: -20 C, Avoid Freeze/Thaw Cycles...
Biology Products: