Navigation Links
Scientists discover new way protein degradation is regulated
Date:4/26/2013

nd human cells, Cho-Park and Steller discovered that tankyrase uses a process called ADP-ribosylation to modify PI31, a key factor that regulates the activity and assembly of proteasome subunits into the active complex called 26S. By promoting the assembly of more 26S particles, cells under stress can boost their ability to break down and dispose of unwanted proteins.

The proteasome is currently a target for developing cancer therapeutics. The FDA has approved Velcade, a proteasome inhibitor, for the treatment of multiple myeloma and mantle cell lymphoma. However, patients on Velcade can experience peripheral neuropathy or become resistant to the drug.

Multiple myeloma cells need increased proteasome activity to survive. Preliminary data from Cho-Park and Steller show that XAV939 can block the growth of multiple myeloma cells by inhibiting the assembly of additional proteasomes without affecting the basal level of proteasomes in the cell. This selective targeting may mean fewer side effects for patients. "Drugs, such as XAV939, that inhibit the proteasome through other mechanisms than Velcade may have significant clinical value," says Steller.

The findings by Cho-Park and Steller also link, for the first time, metabolism and regulation of the proteasome. Sometimes the proteasome digests too much protein, which can lead to loss of muscle, says Steller.

"This discovery reveals fundamental insights into protein degradation, a process important for normal cell biology, and a key factor in disorders such as muscle wasting and neurodegeneration," said Stefan Maas of the National Institutes of Health's National Institute of General Medical Sciences, which partly supported the study. "Intriguingly, the findings also enlighten ongoing research on cancer therapies, exemplifying the impact of basic research on drug development."


'/>"/>

Contact: Joseph Bonner
joseph.bonner@rockefeller.edu
212-327-8998
Rockefeller University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Europe needs genetically engineered crops, scientists say
2. Scientists awarded $5.5 million for wheat, rice blast research
3. Study led by NUS scientists reveals escalating cost of forest conservation
4. Scientists map all possible drug-like chemical compounds
5. Scientists find ethnicity linked to antibodies
6. University of Southern California scientists reveal natural process that blocks viruses
7. Scientists look to ancient past to better predict how species may respond climate change
8. Scientists learn what makes nerve cells so strong
9. Inter-American Network of Science Academies celebrates women scientists -- April 17 event
10. A novel surface marker helps scientists fish out mammary gland stem cells
11. Scientists stress need for national marine biodiversity observation network
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/29/2014)... received a five-year, $6 million grant for clinical ... and development of safe and effective treatments for ... the National Institutes of Health, National Institute on ... Medication Development for Cocaine Use Disorder to oversee ... decisions on moving forward with more expensive large-scale ...
(Date:9/29/2014)... culture, mathematics is often deemed inaccessible or esoteric. Yet ... important role in our daily lives and a decisive ... often behind the scenes. , UC Santa Barbara,s ... and an assistant professor of mechanical engineering, often works ... his recent research published in the Proceedings of ...
(Date:9/29/2014)... The U.S. Department of Energy Joint Genome Institute ... facility, has announced that 32 new projects have ... (CSP). From sampling Antarctic lakes to Caribbean waters, ... underneath the water table in forested watersheds, the ... DOE mission-relevant science can be extracted. , ...
Breaking Biology News(10 mins):New VCU center to target cocaine addiction 2At the interface of math and science 2At the interface of math and science 3At the interface of math and science 42015 DOE JGI's science portfolio delves deeper into the Earth's data mine 22015 DOE JGI's science portfolio delves deeper into the Earth's data mine 32015 DOE JGI's science portfolio delves deeper into the Earth's data mine 42015 DOE JGI's science portfolio delves deeper into the Earth's data mine 52015 DOE JGI's science portfolio delves deeper into the Earth's data mine 62015 DOE JGI's science portfolio delves deeper into the Earth's data mine 72015 DOE JGI's science portfolio delves deeper into the Earth's data mine 82015 DOE JGI's science portfolio delves deeper into the Earth's data mine 9
... release is available in Spanish . , ... viable alternative to petroleum-based packaging products, according to a ... Tomasula for a new book, "Dairy-Derived Ingredients: Food ... by an international team of contributors and published by ...
... "original insect wrangler" who tamed 25,000 roaches, and trained ... of the Lambs," headlines the Southwest,s first Social Insect ... Garden. Designed for inquiring minds and families, the ... Arizona State University, their favorite critters and the public. ...
... breeding and high-intensity x-rays is being used by ... Research Council (BBSRC) to explore the possibility of ... potentially life-saving mineral enriched flour. The research is ... quarterly highlights magazine of BBSRC. Scientists from ...
Cached Biology News:Potential of dairy-based package wraps outlined 2Insect wranglers invade the garden at Southwestern science EXPO 2Scientists using X-ray vision to produce more nutritious flour 2
(Date:9/29/2014)... TORONTO , Sept. 29, 2014 /PRNewswire/ - Portage Biotech ... Exchange: PBT.U), is pleased to announce that its three ... of Portage, who advanced $ 100,000 each in July ... have their Notes and related Coupons converted into 3,500,001 ... and carried 5% coupon. Both the Note and the ...
(Date:9/29/2014)... Transparency Market Research, in its report titled ‘Peptide ... Application - Cancer, Metabolic, CVS, CNS & others, by ... Global Industry Analysis, Size, Share, Growth, Trends and Forecast, ... market was worth US$14.1 billion in 2011 and is ... 8.7% CAGR. , The two main types of peptide ...
(Date:9/29/2014)... METTLER TOLEDO’s new line of XPE balances includes ... balances as well as automated dosing with the ... out their daily weighing tasks worry free, safe in ... reliable and compliant results, thanks to new technologies such ... biggest challenges in analytical and micro-analytical weighing – electrostatic ...
(Date:9/29/2014)... Sept. 29, 2014 CytRx Corporation (NASDAQ: ... development company specializing in oncology, today announced that ... granted multiple Orphan Drug Designations for the Company,s ... multiforme (GBM), small cell lung cancer and ovarian ... widely-used chemotherapeutic agent, doxorubicin. "The FDA,s ...
Breaking Biology Technology:Portage announces conversion of its debt into equity 2Portage announces conversion of its debt into equity 3Global Peptide Therapeutics Market to be Worth US$25.4 Billion by 2018: Transparency Market Research 2Global Peptide Therapeutics Market to be Worth US$25.4 Billion by 2018: Transparency Market Research 3New Line of XPE Balances from METLER TOLEDO is Designed for High Performance and Ease of Compliance 2CytRx Receives Multiple FDA Orphan Drug Designations for Aldoxorubicin for the Treatment of Glioblastoma, Small Cell Lung Cancer and Ovarian Cancer 2CytRx Receives Multiple FDA Orphan Drug Designations for Aldoxorubicin for the Treatment of Glioblastoma, Small Cell Lung Cancer and Ovarian Cancer 3CytRx Receives Multiple FDA Orphan Drug Designations for Aldoxorubicin for the Treatment of Glioblastoma, Small Cell Lung Cancer and Ovarian Cancer 4CytRx Receives Multiple FDA Orphan Drug Designations for Aldoxorubicin for the Treatment of Glioblastoma, Small Cell Lung Cancer and Ovarian Cancer 5
... California, San Diego electrical engineers have created experimental ... to highly efficient thin-film solar cells of the ... as electron superhighways that carry electrons kicked loose ... electron-attracting electrode and this scenario could boost ...
... Morrow, who will graduate from Rensselaer Polytechnic Institute on ... his days as an elementary school student, pulling apart ... developed two innovations that could vastly improve magnetic data ... everything from ink on counterfeit currency to tissue in ...
... improvement is achieved by the use of an ultra-thin aluminum ... brings a breakthrough in the use of solar energy a ... cent (in absolute terms) may at first glance appear modest, ... the performance of their products. This is because higher efficiency ...
Cached Biology Technology:Nanowires may boost solar cell efficiency, UC San Diego engineers say 2Nanowires may boost solar cell efficiency, UC San Diego engineers say 3Nanowires may boost solar cell efficiency, UC San Diego engineers say 4Commencement 2008: Student innovation could improve data storage, magnetic sensors 2New efficiency record for solar cells 2
... The Rapid DNA Ligation ... or blunt-end DNA fragments in ... C. Depending on the ... DNA concentration) or concatemeric (high ...
... Polynucleotide Kinase catalyzes the transfer ... to the 5-terminus of polynucleotides ... 5-hydroxyl group. The enzyme, purified ... be used to phosphorylate RNA, ...
...
... CryoMed Freezers for IVF are designed for ... control, ease of setup and operation, and ... status are continuously displayed on the control ... data are printed by way of the ...
Biology Products: