Navigation Links
Scientists discover new protein that gets to the roots of obesity and osteoporosis

Here's good news for anyone trying to lose weight or has osteoporosis: Scientists from Maine are on the trail of a weight loss drug that may revolutionize how we treat these two conditions. In a new research report published in the September 2010 print issue of The FASEB Journal, the researchers describe a newly discovered protein, called "Sprouty," responsible for regulating body fat and bone mass. Then they manipulated how much of this protein was expressed in different groups of mice specially bred to have some human genes. They found that the more of this protein that the transgenic mice expressed, the leaner and stronger they became. Furthermore, the scientists found that when mice with low levels of the Sprouty protein were made to express more of it, they lost weight and increased bone density.

"When the U.S. military has to turn to fitness gurus like Tony Horton to help its soldiers slim down, you know obesity is a serious problem," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal, "and all you have to do is visit to a nursing home to see the devastating effects of osteoporosis. "Sprouty" well named gets to the roots of extra fat and shrinking bone."

To make this discovery, the researchers studied two groups of transgenic mice, one group with a genetic deletion of the Sprouty gene in cells that develop into fat and bone, and the second group with high levels of expressed Sprouty proteins in the same cell types. Results showed that the mice with the deleted Sprouty gene had increased body fat and loss of bone mass similar to osteoporosis as compared to normal mice. Bone loss was then reversed by adding more Sprouty protein. The group with excess Sprouty expression produced lean mice with increased bone mass.

"Our study provides insight into the regulation of bone mass and body fat," said Lucy Liaw, Ph.D., co-author of the study from the Maine Medical Center Research Institute in Scarborough, ME. "Therefore, future application of this knowledge may help treat common conditions such as bone loss and obesity."


Contact: Cody Mooneyhan
Federation of American Societies for Experimental Biology

Related biology news :

1. Scientists concerned about environmental impact of recycling of e-waste
2. Plant scientists move closer to making any crop drought-tolerant
3. Scripps Research scientists uncover new mechanism of memory formation
4. New Naked Scientists series investigates our oceans
5. NSU scientists receive BP money to research oil spills impact
6. Smithsonian scientists help create first frozen repository for Hawaiian coral
7. Sturgeon, paddlefish scientists from North America to meet Aug. 31-Sept. 2 in Montana
8. Rice sociologist finds male scientists regret parenthood decisions more than female counterparts
9. Scientists find new twist on drug screening to treat common childhood cancer
10. Scientists uncover Achilles heel of chronic inflammatory pain
11. Scientists successfully use human induced pluripotent stem cells to treat Parkinsons in rodents
Post Your Comments:
(Date:11/19/2015)... , Nov. 19, 2015  Based on its in-depth ... Sullivan recognizes BIO-key with the 2015 Global Frost & ... Frost & Sullivan presents this award to the company ... to the needs of the market it serves. The ... meets and expands on customer base demands, the overall ...
(Date:11/18/2015)... 2015 --> ... market report titled  Gesture Recognition Market - Global Industry ... 2021. According to the report, the global gesture recognition market was valued ... reach US$29.1 bn by 2021, at a CAGR of ... America dominated the global gesture recognition market ...
(Date:11/17/2015)... 2015  Vigilant Solutions announces today that Mr. ... Directors. --> --> ... the partnership at TPG Capital, one of the largest ... Billion in revenue.  He founded and led TPG,s Operating ... companies, from 1997 to 2013.  In his first role, ...
Breaking Biology News(10 mins):
(Date:11/24/2015)... AVIV, Israel , Nov. 24, 2015  Tikcro Technologies Ltd. (OTCQB: ... held on December 29, 2015 at 11:00 a.m. Israel ... Co., Electra Tower, 98 Yigal Allon Street, 36 th Floor, ... election of Eric Paneth and Izhak Tamir to ... and Rami Skaliter as external directors; , approval of an amendment ...
(Date:11/24/2015)... Urdorf, Switzerland (PRWEB) , ... November 24, 2015 ... ... the plant and the environment are paramount. Insertion points for in-line sensors can ... TOLEDO has developed the InTrac 781/784 series of retractable sensor housings , ...
(Date:11/24/2015)... Telbec/ - ProMetic Life Sciences Inc. (TSX: PLI) (OTCQX: PFSCF) ... Laurin , President and Chief Executive Officer of ProMetic, will ... 27 th Annual Healthcare Conference to be held at ... st , at 8.50am (ET) and ProMetic,s management ... The presentation will be available live via a webcast accessible ...
(Date:11/24/2015)... , Nov. 24, 2015  PDL BioPharma, Inc. (PDL) (NASDAQ: ... , the company,s president and chief executive officer, will present ... next week in New York City . ... Tuesday, December 1, 2015 at 9:30 a.m. EST. ... to the website at least 15 minutes prior to the ...
Breaking Biology Technology: