Navigation Links
Scientists discover new protein that gets to the roots of obesity and osteoporosis
Date:8/31/2010

Here's good news for anyone trying to lose weight or has osteoporosis: Scientists from Maine are on the trail of a weight loss drug that may revolutionize how we treat these two conditions. In a new research report published in the September 2010 print issue of The FASEB Journal, the researchers describe a newly discovered protein, called "Sprouty," responsible for regulating body fat and bone mass. Then they manipulated how much of this protein was expressed in different groups of mice specially bred to have some human genes. They found that the more of this protein that the transgenic mice expressed, the leaner and stronger they became. Furthermore, the scientists found that when mice with low levels of the Sprouty protein were made to express more of it, they lost weight and increased bone density.

"When the U.S. military has to turn to fitness gurus like Tony Horton to help its soldiers slim down, you know obesity is a serious problem," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal, "and all you have to do is visit to a nursing home to see the devastating effects of osteoporosis. "Sprouty" well named gets to the roots of extra fat and shrinking bone."

To make this discovery, the researchers studied two groups of transgenic mice, one group with a genetic deletion of the Sprouty gene in cells that develop into fat and bone, and the second group with high levels of expressed Sprouty proteins in the same cell types. Results showed that the mice with the deleted Sprouty gene had increased body fat and loss of bone mass similar to osteoporosis as compared to normal mice. Bone loss was then reversed by adding more Sprouty protein. The group with excess Sprouty expression produced lean mice with increased bone mass.

"Our study provides insight into the regulation of bone mass and body fat," said Lucy Liaw, Ph.D., co-author of the study from the Maine Medical Center Research Institute in Scarborough, ME. "Therefore, future application of this knowledge may help treat common conditions such as bone loss and obesity."


'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Related biology news :

1. Scientists concerned about environmental impact of recycling of e-waste
2. Plant scientists move closer to making any crop drought-tolerant
3. Scripps Research scientists uncover new mechanism of memory formation
4. New Naked Scientists series investigates our oceans
5. NSU scientists receive BP money to research oil spills impact
6. Smithsonian scientists help create first frozen repository for Hawaiian coral
7. Sturgeon, paddlefish scientists from North America to meet Aug. 31-Sept. 2 in Montana
8. Rice sociologist finds male scientists regret parenthood decisions more than female counterparts
9. Scientists find new twist on drug screening to treat common childhood cancer
10. Scientists uncover Achilles heel of chronic inflammatory pain
11. Scientists successfully use human induced pluripotent stem cells to treat Parkinsons in rodents
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/3/2016)... 3, 2016  Neurotechnology, a provider of high-precision ... Automated Biometric Identification System (ABIS) , a complete ... MegaMatcher ABIS can process multiple complex biometric transactions ... of fingerprint, face or iris biometrics. It leverages ... and MegaMatcher Accelerator , which have been ...
(Date:4/28/2016)... April 28, 2016 First quarter 2016:   ... 966% compared with the first quarter of 2015 The ... 589.1 M (loss: 18.8) and the operating margin was 40% (-13) ... Cash flow from operations was SEK 249.9 M (21.2) ... guidance is unchanged, SEK 7,000-8,500 M. The operating margin ...
(Date:4/26/2016)... , April 27, 2016 ... "Global Multi-modal Biometrics Market 2016-2020"  report to their ... , The analysts forecast the global ... of 15.49% during the period 2016-2020.  ... of sectors such as the healthcare, BFSI, transportation, ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... June 23, 2016 , ... Charm Sciences, Inc. is ... has received AOAC Research Institute approval 061601. , “This is another AOAC-RI approval ... Bob Salter, Vice President of Regulatory and Industrial Affairs. “The Peel Plate methods ...
(Date:6/23/2016)... ... June 23, 2016 , ... Supplyframe, the Industry ... Supplyframe Design Lab . Located in Pasadena, Calif., the Design Lab’s mission ... hardware projects are designed, built and brought to market. , The Design Lab ...
(Date:6/23/2016)...  Blueprint Bio, a company dedicated to identifying, protecting ... has closed its Series A funding round, according to ... "We have received a commitment from Forentis Fund that ... meet our current goals," stated Matthew Nunez . ... complete validation on the current projects in our pipeline, ...
(Date:6/23/2016)... WI (PRWEB) , ... June 23, 2016 , ... ... focused on quality, regulatory and technical consulting, provides a free webinar ... presented on July 13, 2016 at 12pm CT at no charge. , Incomplete ...
Breaking Biology Technology: